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Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila (2016)
Journal Article
Niccoli, T., Cabecinha, M., Tillmann, A., Kerr, F., Wong, C., Cardenes, D., Vincent, A., Bettedi, L., Li, L., Grönke, S., Dols, J., & Partridge, L. (2016). Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila. Current Biology, 26(17), 2291-2300. https://doi.org/10.1016/j.cub.2016.07.017

Glucose hypometabolism is a prominent feature of the brains of patients with Alzheimer's disease (AD). Disease progression is associated with a reduction in glucose transporters in both neurons and endothelial cells of the blood-brain barrier. Howeve... Read More about Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila.

Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis (2016)
Journal Article
Castillo-Quan, J., Li, L., Kinghorn, K., Ivanov, D., Tain, L., Slack, C., Kerr, F., Nespital, T., Thornton, J., Hardy, J., Bjedov, I., & Partridge, L. (2016). Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis. Cell Reports, 15(3), 638-650. https://doi.org/10.1016/j.celrep.2016.03.041

The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that li... Read More about Lithium Promotes Longevity through GSK3/NRF2-Dependent Hormesis.