Regulation of the expression of DAPK1 by SUMO pathway. (2019)
Journal Article
Wang, Q., Zhang, X., Chen, L., Weng, S., Xia, Y., Ye, Y., Li, K., Liao, Z., Chen, P., Alsamman, K., Meng, C., Stevens, C., Hupp, T. R., & Lin, Y. (2019). Regulation of the expression of DAPK1 by SUMO pathway. Biomolecules, 9(4), 151. https://doi.org/10.3390/biom9040151

Death Associated Protein Kinase 1 (DAPK1) is an important signaling kinase mediating the biological eect of multiple natural biomolecules such as IFN-, TNF-, curcumin, etc. DAPK1 is degraded through both ubiquitin-proteasomal and lysosomal degradat... Read More about Regulation of the expression of DAPK1 by SUMO pathway..

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2 (2008)
Journal Article
Stevens, C., Pettersson, S., Wawrzynow, B., Wallace, M., Ball, K., Zylicz, A., & Hupp, T. R. (2008). ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2. FEBS Journal, 275(19), 4875-4886. https://doi.org/10.1111/j.1742-4658.2008.06627.x

Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit... Read More about ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2.

A New Role for E2F-1 in Checkpoint Control (2003)
Journal Article
Stevens, C., & Thangue, N. B. L. (2003). A New Role for E2F-1 in Checkpoint Control. Cell Cycle, 2(5), 434-436. https://doi.org/10.4161/cc.2.5.462

In response to DNA damage, E2F-1 is induced and phosphorylated. Phosphorylated E2F-1 can reside in discrete nuclear structures and induce apoptosis, suggesting a unique role for E2F-1 in DNA repair and checkpoint functions.

Chk2 activates E2F-1 in response to DNA damage (2003)
Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 c... Read More about Chk2 activates E2F-1 in response to DNA damage.

E2F and cell cycle control: a double-edged sword (2003)
Journal Article
Stevens, C., & La Thangue, N. B. (2003). E2F and cell cycle control: a double-edged sword. Archives of Biochemistry and Biophysics, 412(2), 157-169. https://doi.org/10.1016/s0003-9861%2803%2900054-7

The E2F family of transcription factors plays a central role in regulating cellular proliferation by controlling the expression of both the genes required for cell cycle progression, particularly DNA synthesis, and the genes involved with apoptosis.... Read More about E2F and cell cycle control: a double-edged sword.