Skip to main content

Research Repository

Advanced Search

Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe. (2012)
Journal Article
Zhao, Z., San, M., Duprey, J. H. A., Arrand, J. R., Vyle, J. S., & Tucker, J. H. R. (2012). Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe. Bioorganic and Medicinal Chemistry Letters, 22, 129-132. https://doi.org/10.1016/j.bmcl.2011.11.053

Single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer were identified using oligodeoxynucleotide probe sequences bearing internal anthracene fluorophores proximal to the SNP site. Depending upon the nature of the... Read More about Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe..

A ferrocene nucleic acid oligomer as an organometallic structural mimic of DNA (2012)
Journal Article
Nguyen, H. V., Zhao, Z., Sallustrau, A., Horswell, S. L., Male, L., Mulas, A., & Tucker, J. H. R. (2012). A ferrocene nucleic acid oligomer as an organometallic structural mimic of DNA. Chemical Communications, 48, 12165. https://doi.org/10.1039/C2CC36428J

The design, synthesis and electrochemical behaviour of an oligomer consisting of linked thymine-functionalised ferrocene units are reported, which, as a so-called form of ferrocene nucleic acid (FcNA), acts as a structural mimic of DNA.

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe (2011)
Journal Article
Duprey, J. H. A., Zhao, Z., Bassani, D. M., Manchester, J., Vyle, J. S., & Tucker, J. H. R. (2011). Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe. Chemical Communications, 47, 6629. https://doi.org/10.1039/c1cc11205h

A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeCvia a hybridisation sensing assay.