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Outputs (9)

Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling (2024)
Preprint / Working Paper
Elsharkasi, M., Villani, B., Wells, G., & Kerr, F. Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling

As a gate-keeper of anti-oxidant, anti-inflammatory and xenobiotic cell protection mechanisms, the transcription factor Nrf2 has been implicated as a promising therapeutic target for several neurodegenerative diseases, leading to the development of N... Read More about Basal activation of astrocytic Nrf2 in neuronal culture media: challenges and implications for neuron-astrocyte modelling.

Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa (2024)
Journal Article
Orzel, D., Ravald, H., Dillon, A., Rantala, J., Wiedmer, S. K., & Russo, G. (2024). Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa. Journal of Chromatography A, 1734, Article 465286. https://doi.org/10.1016/j.chroma.2024.465286

This study pioneers a comparison of the application of biomimetic techniques, immobilised artificial membrane liquid chromatography (IAM LC) and liposome electrokinetic capillary chromatography (LEKC), for the prediction of pulmonary drug permeabilit... Read More about Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa.

β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting (2024)
Journal Article
Baghestani, S., Haldin, C., Kosijer, P., Alam, C. M., & Toivola, D. M. (2024). β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting. American Journal of Physiology - Cell Physiology, 327(2), C462-C476. https://doi.org/10.1152/ajpcell.00123.2024

Islet β-cell dysfunction is an underlying factor for type I diabetes (T1D) development. Insulin sensing and secretion are tightly regulated in β-cells at multiple subcellular levels. The epithelial intermediate filament (IF) protein keratin (K) 8 is... Read More about β-Cell keratin 8 maintains islet mechanical integrity, mitochondrial ultrastructure, and β-cell glucose transporter 2 plasma membrane targeting.

Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360) (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360). Food Standards Agency

An application was submitted to the Food Standards Agency in March 2021 from DSM Nutritional Products LTD (“the applicant”) for the new authorisation of an additive (ProAct 360) containing protease (subtilisin), under the category of “zootechnical ad... Read More about Safety Assessment RP709 protease (subtilisin) produced by Bacillus licheniformis DSM 33099 (ProAct 360).

Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®) (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®). Food Standards Agency

An application was submitted to the Food Standards Agency in April 2021 from Phibro Animal Health Corporation (“the applicant”) for the new authorisation of an additive (Magni-Phi®), a natural preparation of powdered dry Quillaja saponaria and dry Yu... Read More about Safety Assessment RP1047 Quillaja saponaria and Yucca schidigera (Magni-Phi®).

Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species (2024)
Report
Morrison, D., & Wheelhouse, N. (2024). Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species. Food Standards Agency

An application was submitted to the Food Standards Agency in May 2021 from AlzChem Trostberg GmbH (“the applicant”) for the new use authorisation of an additive guanidinoacetic acid (Creamino®), under the category of ‘nutritional additives” and funct... Read More about Assessment of the safety and efficacy of Guanidinoacetic acid (Creamino®) as a feed additive for all animal species.