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Outputs (216)

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study (2019)
Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), Article 992. https://doi.org/10.1186/s12889-019-7313-0

Background
Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital tract, C. trachomatis is found in the throat and rectum, suggesting the n... Read More about Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study.

Applied anatomy and physiology and the renal disease process (2019)
Book Chapter
Chalmers, C. (2019). Applied anatomy and physiology and the renal disease process. In Renal nursing: Care and management of people with kidney disease (21-58). (5). Wiley. https://doi.org/10.1002/9781119413172.ch2

This chapter provides the reader with a detailed discussion of all aspects of renal physiology and its relationship to important pathophysiological processes in renal disease, and some brief discussion on related nursing observations. It first explor... Read More about Applied anatomy and physiology and the renal disease process.

How to build a bone: PHOSPHO1, biomineralization and beyond (2019)
Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019). How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), Article e10202. https://doi.org/10.1002/jbm4.10202

Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role in the biomineralization of bone and other hard tissues, but has also impli... Read More about How to build a bone: PHOSPHO1, biomineralization and beyond.

Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing (2019)
Journal Article
Dancer, S. J., Adams, C. E., Smith, J., Pichon, B., Kearns, A., & Morrison, D. (2019). Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing. Journal of Hospital Infection, 103(1), 13-20. https://doi.org/10.1016/j.jhin.2019.04.016

Background: Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU).

Methods... Read More about Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing.

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK (2019)
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., Henderson, P., & Stevens, C. (2019). The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039

Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD)... Read More about The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK.

The Ex Vivo Organ Culture of Bone (2019)
Book Chapter
Staines, K. A., Brown, G., & Farquharson, C. (2019). The Ex Vivo Organ Culture of Bone. In Bone Research Protocols (199-215). Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_10

The ex vivo organ culture of bone provides many of the advantages of both the whole organism and isolated cell strategies and can deliver valuable insight into the network of processes and activities that are fundamental to bone and cartilage biology... Read More about The Ex Vivo Organ Culture of Bone.

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy (2019)
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., Barlow, P., & Stevens, C. (2019). The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), Article e0209665. https://doi.org/10.1371/journal.pone.0209665

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively... Read More about The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., Benavides, J., Palarea-Albaladejo, J., Mcinnes, C. J., Ballingall, K., & Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions (2019)
Journal Article
Smith, K., Muggeridge, D. J., Easton, C., & Ross, M. D. (2019). An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions. European Journal of Applied Physiology, 119(3), 723-733. https://doi.org/10.1007/s00421-018-04063-9

Purpose: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. However, the ergogenic effects of dietary NO3- on intermittent exercise performance in hot conditions has... Read More about An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions.

Ferlavirus-related deaths in a collection of viperid snakes (2018)
Journal Article
Flach, E. J., Dagleish, M. P., Feltrer, Y., Gill, I. S., Marschang, R. E., Masters, N., Orós, J., Pocknell, A., Rendle, M. E., Strike, T., Tapley, B., & Wheelhouse, N. M. (2018). Ferlavirus-related deaths in a collection of viperid snakes. Journal of Zoo and Wildlife Medicine, 49(4), 983-995. https://doi.org/10.1638/2017-0223.1

Between June and October 2013 26 snakes of six viperid species kept in two adjoining rooms died (n = 16) or were euthanized on medical (1) or welfare grounds (9). Two were from the main zoo collection, but the other 24 had been imported and quarantin... Read More about Ferlavirus-related deaths in a collection of viperid snakes.

Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry (2018)
Journal Article
Dancer, S. J., & Kramer, A. (2019). Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry. Journal of Hospital Infection, 103(1), e1-e8. https://doi.org/10.1016/j.jhin.2018.12.015

Background
Now that cleaning and decontamination are recognised as integral to infection control, it is timely to examine the process in more detail. This is because cleaning practices vary widely within healthcare districts and it is likely that bo... Read More about Four Steps to Clean Hospitals: Look; Plan; Clean; and Dry.

Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease (2018)
Journal Article
Hooper, K. M., Barlow, P. G., Henderson, P., & Stevens, C. (2019). Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease. Inflammatory Bowel Diseases, 25(4), 661-671. https://doi.org/10.1093/ibd/izy380

Inflammatory Bowel Disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterised by chronic inflammation of the gastrointestinal tract. Aetiology involves a combination of genetic and environmental factors resulting in a... Read More about Interactions Between Autophagy and the Unfolded Protein Response: Implications for Inflammatory Bowel Disease.

Researching skills development: students as partners in this process (2018)
Journal Article
Campbell Casey, S., MacCallum, J., Robertson, L., & Strachan, L. (2018). Researching skills development: students as partners in this process. New Directions in the Teaching of Physical Sciences, 13(1), https://doi.org/10.29311/ndtps.v0i13.2881

Many employers report that newly qualified graduates lack key skills necessary for success in the workplace. Although variable, many lack general ‘transferable’ or ‘soft’ skills including communication and teamworking. Staff at Edinburgh Napier Unive... Read More about Researching skills development: students as partners in this process.

Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity (2018)
Journal Article
Ross, M. D. (2018). Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity. Current Cardiology Reviews, 14(4), 233-244. https://doi.org/10.2174/1573403X14666180726112303

The endothelium plays an important role in cardiovascular regulation, from blood flow, to platelet aggregation, immune cell infiltration and demargination. A dysfunctional endothelium leads to the onset and progression of cardiovascular disease (CVD)... Read More about Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity.

Protracted diagnosis of ACNES: a costly exercise (2018)
Journal Article
Dancer, S. J., Macpherson, S. G., & de Beaux, A. C. (2018). Protracted diagnosis of ACNES: a costly exercise. Journal of Surgical Case Reports, 2018(9), 1-3. https://doi.org/10.1093/jscr/rjy230

This case report summarizes the course of events leading to diagnosis and eventual repair of anterior cutaneous nerve entrapment syndrome (ACNES) in a 58-year-old female. The time period elapsing from initial symptoms to final operative repair was 9... Read More about Protracted diagnosis of ACNES: a costly exercise.

Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring (2018)
Journal Article
Wauters, J., Wilson, K. S., Bouts, T., Valentine, I., Vanderschueren, K., Ververs, C., Howie, A. F., Rae, M. T., Van Soom, A., Li, R., Li, D., Zhang, H., & Vanhaecke, L. (2018). Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring. PLOS ONE, 13(7), Article e0201420. https://doi.org/10.1371/journal.pone.0201420

Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results requires normalisation due to an animal’s changing hydration. Correction of urinar... Read More about Urinary specific gravity as an alternative for the normalisation of endocrine metabolite concentrations in giant panda (Ailuropoda melanoleuca) reproductive monitoring.

Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study (2018)
Journal Article
Ledwoch, K., Dancer, S., Otter, J., Kerr, K., Roposte, D., Rushton, L., Weiser, R., Mahenthiralingam, E., Muir, D., & Maillard, J.-Y. (2018). Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study. Journal of Hospital Infection, https://doi.org/10.1016/j.jhin.2018.06.028

Background
Wet biofilms associated with medical devices have been widely studied and their link with healthcare-associated infections (HCAIs) is well recognized. Little attention has been paid to the presence of dry biofilms on environmental surface... Read More about Beware Biofilm! Dry biofilms containing bacterial pathogens on multiple healthcare surfaces; a multicentre study.

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men (2018)
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018). Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), Article e13697. https://doi.org/10.14814/phy2.13697

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T-cells (angiogenic T-cells; TANG) possess highly angiogenic capa... Read More about Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men.