Outputs (14)

Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo (2019)
Journal Article
Mathur, S., Turnbull, A., Akaev, I., Stevens, C., Agrawal, N., Chopra, M., & Mincher, D. (2020). Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo. International Journal of Peptide Research and Therapeutics, 26, 1965-1980. https://doi.org/10.1007/s10989-019-09994-1

The lysosomal endoprotease legumain (asparaginyl endoprotease) has been proposed as a putative biomarker in prostate tumours, in which the enzyme is markedly overexpressed. Overexpression, coupled with highly selective specificity for cleavage of sub... Read More about Design of a New Peptide Substrate Probe of the Putative Biomarker Legumain with Potential Application in Prostate Cancer Diagnosis ex vivo.

In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography (2019)
Journal Article
Madi, K., Staines, K., Bay, B., Javaheri, B., Geng, H., Bodey, A., Cartmell, S., Pitsillides, A., & Lee, P. (2020). In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography. Nature Biomedical Engineering, 4(3), 343-354. https://doi.org/10.1038/s41551-019-0477-1

Imaging techniques for quantifying changes in the hierarchical structure of deforming joints are constrained by destructive sample treatments, sample-size restrictions and lengthy scan times. Here, we report the use of fast low-dose pink-beam synchro... Read More about In situ characterization of nanoscale strains in loaded whole joints via synchrotron X-ray tomography.

Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential (2019)
Journal Article
Sharma, A., Goring, A., Staines, K., Emery, R., Pitsillides, A. A., Oreffo, R. O., Mahajan, S., & Clarkin, C. E. (2020). Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential. Matrix Biology Plus, 5, https://doi.org/10.1016/j.mbplus.2019.100018

Mineralization of bone is achieved by the sequential maturation of the immature amorphous calcium phase to mature hydroxyapatite and is central to the process of bone development and repair. To study normal and dysregulated mineralization in vitro, s... Read More about Raman spectroscopy links differentiating osteoblast matrix signatures to pro-angiogenic potential.

Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds (2019)
Journal Article
Harnoss, J., Dancer, S., Kaden, C., Baguhl, R., Kohlmann, T., Papke, R., Zygmunt, M., Assadian, O., Suchomel, M., Pittet, D., & Kramer, A. (2020). Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds. Journal of Hospital Infection, 104(4), 419-424. https://doi.org/10.1016/j.jhin.2019.09.004

Background
A previous study among neonatal intensive care unit (NICU) nurses showed that the antibacterial efficacy of alcohol-based handrubs (ABHR) can be achieved in 15 s instead of 30 s with a significant increase in the frequency of hand antisep... Read More about Hand antisepsis without decreasing efficacy by shortening the rub-in time of alcohol-based handrubs to 15 seconds.

Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis (2019)
Journal Article
Staines, K., Ikpegbu, E., Törnqvist, A., Dillon, S., Javaheri, B., Amin, A. K., Clements, D. N., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2019). Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis. BMC Musculoskeletal Disorders, 20, Article 344 (2019). https://doi.org/10.1186/s12891-019-2731-9

Background: Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption... Read More about Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis.

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study (2019)
Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), Article 992. https://doi.org/10.1186/s12889-019-7313-0

Background
Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital tract, C. trachomatis is found in the throat and rectum, suggesting the n... Read More about Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study.

Applied anatomy and physiology and the renal disease process (2019)
Book Chapter
Chalmers, C. (2019). Applied anatomy and physiology and the renal disease process. In Renal nursing: Care and management of people with kidney disease (21-58). (5). Wiley. https://doi.org/10.1002/9781119413172.ch2

This chapter provides the reader with a detailed discussion of all aspects of renal physiology and its relationship to important pathophysiological processes in renal disease, and some brief discussion on related nursing observations. It first explor... Read More about Applied anatomy and physiology and the renal disease process.

How to build a bone: PHOSPHO1, biomineralization and beyond (2019)
Journal Article
Dillon, S., Staines, K. A., Millán, J. L., & Farquharson, C. (2019). How to build a bone: PHOSPHO1, biomineralization and beyond. Journal of Bone and Mineral Research Plus, 3(7), Article e10202. https://doi.org/10.1002/jbm4.10202

Since its characterization two decades ago, the phosphatase PHOSPHO1 has been the subject of an increasing focus of research. This work has elucidated PHOSPHO1’s central role in the biomineralization of bone and other hard tissues, but has also impli... Read More about How to build a bone: PHOSPHO1, biomineralization and beyond.

Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing (2019)
Journal Article
Dancer, S. J., Adams, C. E., Smith, J., Pichon, B., Kearns, A., & Morrison, D. (2019). Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing. Journal of Hospital Infection, 103(1), 13-20. https://doi.org/10.1016/j.jhin.2019.04.016

Background: Staphylococcus aureus remains an important bacterial pathogen worldwide. This study utilized known staphylococcal epidemiology to track S. aureus between different ecological reservoirs in one ten-bed intensive care unit (ICU).

Methods... Read More about Tracking Staphylococcus aureus in the intensive care unit using Whole-Genome Sequencing.

The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK (2019)
Journal Article
Hooper, K. M., Casanova, V., Kemp, S., Staines, K. A., Satsangi, J., Barlow, P. G., Henderson, P., & Stevens, C. (2019). The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK. Inflammatory Bowel Diseases, 25(9), 1481-1496. https://doi.org/10.1093/ibd/izz039

Background Genetic studies have strongly linked autophagy to Crohn's disease (CD) and stimulating autophagy in CD patients may be therapeutically beneficial. The aim of this study was to evaluate the effect of current inflammatory bowel disease (IBD)... Read More about The inflammatory bowel disease drug azathioprine induces autophagy via mTORC1 and the unfolded protein response sensor PERK.

The Ex Vivo Organ Culture of Bone (2019)
Book Chapter
Staines, K. A., Brown, G., & Farquharson, C. (2019). The Ex Vivo Organ Culture of Bone. In Bone Research Protocols (199-215). Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_10

The ex vivo organ culture of bone provides many of the advantages of both the whole organism and isolated cell strategies and can deliver valuable insight into the network of processes and activities that are fundamental to bone and cartilage biology... Read More about The Ex Vivo Organ Culture of Bone.

The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy (2019)
Journal Article
Biskou, O., Casanova, V., Hooper, K., Kemp, S., Wright, G. P., Satsangi, J., Barlow, P., & Stevens, C. (2019). The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy. PLOS ONE, 14(1), Article e0209665. https://doi.org/10.1371/journal.pone.0209665

The cytoskeletal protein vimentin plays a key role in positioning of organelles within the cytosol and has been linked to the regulation of numerous cellular processes including autophagy, however, how vimentin regulates autophagy remains relatively... Read More about The type III intermediate filament vimentin regulates organelle distribution and modulates autophagy.

Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction (2019)
Journal Article
Wattegedera, S. R., Doull, L. E., Goncheva, M. I., Wheelhouse, N., Watson, D. M., Pearce, J., Benavides, J., Palarea-Albaladejo, J., Mcinnes, C. J., Ballingall, K., & Entrican, G. (2019). Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction. Frontiers in Immunology, 9, https://doi.org/10.3389/fimmu.2018.03025

Successful mammalian pregnancies are a result of complex physiological, endocrinological and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that... Read More about Immunological homeostasis at the ovine placenta may reflect the degree of maternal foetal interaction.

An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions (2019)
Journal Article
Smith, K., Muggeridge, D. J., Easton, C., & Ross, M. D. (2019). An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions. European Journal of Applied Physiology, 119(3), 723-733. https://doi.org/10.1007/s00421-018-04063-9

Purpose: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. However, the ergogenic effects of dietary NO3- on intermittent exercise performance in hot conditions has... Read More about An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions.