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The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies (1989)
Book Chapter
Darlison, M. G., Barnard, E. A., Bateson, A. N., Glencorse, T. A., Harvey, R. J., Hicks, A. A., Hunt, S. P., Morris, B. J., Vallejo, M., Vreugdenhil, E., & Wisden, W. (1989). The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies. In Molecular Biology of Neuroreceptors and Ion Channels (83-99). Springer. https://doi.org/10.1007/978-3-642-74155-5_7

It is well established that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) mediates many of its effects by binding to the GABAA receptor, which is present on the majority of mammalian brain neurons (Enna, 1983), resulting in the opening o... Read More about The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies.

Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer (1989)
Journal Article
Wisden, W., McNaughton, L. A., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer. Neuroscience Letters, 106(1-2), 7-12. https://doi.org/10.1016/0304-3940%2889%2990193-6

Using in situ hybridization histochemistry, we have demonstrated that 3 α subunit mRNAs of the {GABAA} receptor are present in different cell populations of the bovine cerebellum. While the α1 mRNA is the most abundant and is present in granule cells... Read More about Differential distribution of GABAA receptor mRNAs in bovine cerebellum — Localization of α2 mRNA in Bergmann glia layer.

Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease (1989)
Journal Article
Buckle, V. J., Fujita, N., Ryder-Cook, A. S., Derry, J. M., Barnard, P. J., Lebo, R. V., Schofield, P. R., Seeburg, P. H., Bateson, A. N., Darlison, M. G., & Barnard, E. A. (1989). Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease. Neuron, 3(5), 647-654. https://doi.org/10.1016/0896-6273%2889%2990275-4

Hybridization of {GABAA} receptor probes to human chromosomes in situ and to {DNA} from sorted human chromosomes has localized the genes encoding a β subunit and three isoforms of the a subunit. The α2 and β genes are both located on chromosome 4 in... Read More about Chromosomal localization of GABAA receptor subunit genes: relationship to human genetic disease.

The molecular basis of muscular dystrophy in the mdx mouse: a point mutation (1989)
Journal Article
Sicinski, P., Geng, Y., Ryder-Cook, A., Barnard, E., Darlison, M., & Barnard, P. (1989). The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science, 244(4912), 1578-1580. https://doi.org/10.1126/science.2662404

The mdx mouse is an X-linked myopathic mutant, an animal model for human Duchenne muscular dystrophy. In both mouse and man the mutations lie within the dystrophin gene, but the phenotypic differences of the disease in the two species confer much int... Read More about The molecular basis of muscular dystrophy in the mdx mouse: a point mutation.

Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes (1989)
Journal Article
Wisden, W., Morris, B. J., Darlison, M. G., Hunt, S. P., & Barnard, E. A. (1989). Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes. Molecular Brain Research, 5(4), 305-310. https://doi.org/10.1016/0169-328x%2889%2990065-x

The distribution of 3 {GABAA} receptor α-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the α2- and α3-transcripts are of low abundance in all regions except striatum, the α1-transcript is... Read More about Localization of GABAA receptor α-subunit mRNAs in relation to receptor subtypes.