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Outputs (15)

De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations (2021)
Journal Article
Arshia, A. H., Shadravan, S., Solhjoo, A., Sakhteman, A., & Sami, A. (2021). De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations. Computers in Biology and Medicine, 139, Article 104967. https://doi.org/10.1016/j.compbiomed.2021.104967

The main protease of SARS-CoV-2 is a critical target for the design and development of antiviral drugs. 2.5 M compounds were used in this study to train an LSTM generative network via transfer learning in order to identify the four best candidates ca... Read More about De novo design of novel protease inhibitor candidates in the treatment of SARS-CoV-2 using deep learning, docking, and molecular dynamic simulations.

The effectiveness of cognitive-behavioural interventions at increasing adherence to physical activity in mental health populations: a systematic review (2019)
Journal Article
Snowden, A., Peddie, N., & Westbury, T. (2021). The effectiveness of cognitive-behavioural interventions at increasing adherence to physical activity in mental health populations: a systematic review. Advances in Mental Health, 19(1), 94-112. https://doi.org/10.1080/18387357.2019.1684829

Objective: There is growing global evidence for stark inequalities in the physical health status and life-expectancy of people with a mental health diagnosis. In most cases, physical activity (PA) is one of the most effective methods of maintaining p... Read More about The effectiveness of cognitive-behavioural interventions at increasing adherence to physical activity in mental health populations: a systematic review.

Health professionals' lack of knowledge of central venous access devices: the impact on patients (2019)
Journal Article
Kelly, L. J., Snowden, A., Paterson, R., & Campbell, K. (2019). Health professionals' lack of knowledge of central venous access devices: the impact on patients. British Journal of Nursing, 28(14), https://doi.org/10.12968/bjon.2019.28.14.S4

Background
The literature on patient experience of living with a central venous access device (CVAD) is growing, but remains sparse. It suggests that patients accept CVADs as should reduce episodes of repeated cannulations. However, a recent doctor... Read More about Health professionals' lack of knowledge of central venous access devices: the impact on patients.

A review of the impact of utilising electronic medical records for clinical research recruitment (2019)
Journal Article
Lai, Y. S., & Afseth, J. D. (2019). A review of the impact of utilising electronic medical records for clinical research recruitment. Clinical Trials, 16(2), 194-203. https://doi.org/10.1177/1740774519829709

Introduction:
Recruitment is an important aspect of clinical research, as poor recruitment could undermine the scientific value of a trial or delay the development process of new treatments. The development of electronic medical records provides a n... Read More about A review of the impact of utilising electronic medical records for clinical research recruitment.

Holistic needs assessment in brain cancer patients: A systematic review of available tools (2018)
Journal Article
Afseth, J., Neubeck, L., Karatzias, T., & Grant, R. (2019). Holistic needs assessment in brain cancer patients: A systematic review of available tools. European Journal of Cancer Care, 28(3), Article e12931. https://doi.org/10.1111/ecc.12931

This systematic review describes tools which could be considered for use for holistic needs assessment in Brain Cancer. MEDLINE, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycINFO were searched. Studies where included wh... Read More about Holistic needs assessment in brain cancer patients: A systematic review of available tools.

Proactive community support tailored to holistic needs: A cohort study (2018)
Journal Article
Snowden, A., Young, J., & Savinc, J. (2018). Proactive community support tailored to holistic needs: A cohort study. Cancer Medicine, 7(9), 4836-4845. https://doi.org/10.1002/cam4.1709

Background:
It is increasingly internationally recognised that a cancer diagnosis impacts on people practically and financially as well as physically and psychologically. It is less clear what to do about this. This study introduces an original com... Read More about Proactive community support tailored to holistic needs: A cohort study.

The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study (2018)
Journal Article
Dobson, C., Russell, A., Brown, S., & Rubin, G. (2018). The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study. European Journal of Cancer Care, 27(2), Article e12815. https://doi.org/10.1111/ecc.12815

Prolonged diagnostic intervals are associated with poorer outcomes, and the patient interval appears to be a substantial contributor to the overall length of the diagnostic interval. This study sought to understand how the broader context of people's... Read More about The role of social context in symptom appraisal and help-seeking among people with lung or colorectal symptoms: A qualitative interview study.

Widening Access; Developing an eLearning Resource for Health and Social Care Professionals Caring for Children and Young People with Cancer (2017)
Journal Article
McInally, W., Pouso Lista, M. J., McLaren, N., & Willis, D. S. (2017). Widening Access; Developing an eLearning Resource for Health and Social Care Professionals Caring for Children and Young People with Cancer. Journal of Cancer Education, https://doi.org/10.1007/s13187-017-1284-6

Cancer is a key priority worldwide, and caring for children and young people with cancer requires a range of specific knowledge, skills and experience in order to deliver the complex care regimes both within the hospital or community environment. The... Read More about Widening Access; Developing an eLearning Resource for Health and Social Care Professionals Caring for Children and Young People with Cancer.

Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial (2007)
Journal Article
Mutrie, N., Campbell, A. M., Whyte, F., McConnachie, A., Emslie, C., Lee, L., Kearney, N., Walker, A., & Ritchie, D. (2007). Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. BMJ, 334(7592), 517. https://doi.org/10.1136/bmj.39094.648553.ae

Objectives To determine functional and psychological benefits of a 12 week supervised group exercise programme during treatment for early stage breast cancer, with six month follow-up.Design Pragmatic randomised controlled prospective open trial.Sett... Read More about Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial.

'I wouldn't have been interested in just sitting round a table talking about cancer'; exploring the experiences of women with breast cancer in a group exercise trial (2006)
Journal Article
Emslie, C., Whyte, F., Campbell, A., Mutrie, N., Lee, L., Ritchie, D., & Kearney, N. (2007). 'I wouldn't have been interested in just sitting round a table talking about cancer'; exploring the experiences of women with breast cancer in a group exercise trial. Health Education Research, 22(6), 827-838. https://doi.org/10.1093/her/cyl159

There is evidence that physical activity improves the psychological and physical health of patients with cancer. However, relatively little attention has been paid to understanding their experiences of exercise. This focus group study explored the ex... Read More about 'I wouldn't have been interested in just sitting round a table talking about cancer'; exploring the experiences of women with breast cancer in a group exercise trial.

Antioxidant and cytoprotective responses to redox stress (2004)
Journal Article
Mathers, J., Fraser, J. A., McMahon, M., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004). Antioxidant and cytoprotective responses to redox stress. Biochemical Society symposia, 71, 157-176. https://doi.org/10.1042/bss0710157

Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental... Read More about Antioxidant and cytoprotective responses to redox stress.

Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form (2001)
Journal Article
Fraser, J. A., Saunders, R. D. C., & McLellan, L. I. (2002). Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form. Journal of Biological Chemistry, 277(2), 1158-1165. https://doi.org/10.1074/jbc.m106683200

Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The existence of a modifier subunit in invertebrates has not been described to dat... Read More about Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form.