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Mittens Intervention for Tube Tugging After Stroke (2005)
Presentation / Conference Contribution
Mahoney, C., Rowat, A., Horsburgh, D., Lewis, S., Taylor, P., Alder, E., & Dennis, M. (2005, May). Mittens Intervention for Tube Tugging After Stroke. Poster presented at British Stroke Association, Harrogate

Mahoney, C. (2005, May). Mittens Intervention for Tube Tugging After Stroke. Poster presented at British Stroke Association, Harrogate.

Mittens Intervention for Tube Tugging After Stroke (2005)
Presentation / Conference Contribution
Mahoney, C. (2005, April). Mittens Intervention for Tube Tugging After Stroke. Presented at Postgraduate Research Conference, Edinburgh

Mahoney, C. (2005, April). Mittens Intervention for Tube Tugging After Stroke. Presented at Postgraduate Research Conference, Edinburgh.

The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus (2004)
Journal Article
Thode, C., Bock, J., Braun, K., & Darlison, M. (2005). The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus. Neuroscience, 130(3), 611-617. https://doi.org/10.1016/j.neuroscience.2004.10.015

The immediate-early gene zenk (an acronym for the avian orthologue of the mammalian genes zif-268, egr-1, ngfi-a and krox-24) has been extensively employed, in studies on oscine birds, as a marker of neuronal activity to reveal forebrain structures t... Read More about The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus.

Antioxidant and cytoprotective responses to redox stress (2004)
Journal Article
Mathers, J., Fraser, J. A., McMahon, M., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004). Antioxidant and cytoprotective responses to redox stress. Biochemical Society symposia, 71, 157-176. https://doi.org/10.1042/bss0710157

Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental... Read More about Antioxidant and cytoprotective responses to redox stress.

Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form (2001)
Journal Article
Fraser, J. A., Saunders, R. D. C., & McLellan, L. I. (2002). Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form. Journal of Biological Chemistry, 277(2), 1158-1165. https://doi.org/10.1074/jbc.m106683200

Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The existence of a modifier subunit in invertebrates has not been described to dat... Read More about Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form.

Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish (2001)
Journal Article
Pohl, S., Darlison, M. G., Clarke, W., Lederis, K., & Richter, D. (2001). Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish. European Journal of Pharmacology, 430(2-3), 193-202. https://doi.org/10.1016/S0014-2999%2801%2901391-7

Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacology of their cognate receptors. Here we report the isolation and functional e... Read More about Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish.

Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit (2001)
Journal Article
Forster, I. C., Harvey, R. J., Darlison, M. G., & Benson, J. A. (2001). Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit. European Journal of Pharmacology, 419(1), 1-7. https://doi.org/10.1016/S0014-2999%2801%2900964-5

The functional pharmacology of receptors composed of the chicken brain {GABAA} receptor γ4 subunit and the mammalian {GABAA} receptor α3 and β2 subunits was studied by heterologous expression in Xenopus laevis oocytes using the two electrode voltage-... Read More about Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit.

Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3 (1999)
Journal Article
Bailey, M. E., Albrecht, B. E., Johnson, K. J., & Darlison, M. G. (1999). Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. BBA - Gene Structure and Expression, 1447(2-3), 307-312. https://doi.org/10.1016/s0167-4781%2899%2900167-0

{GABAC} receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: ρ1 (GABRR1), ρ2 (GABRR2) and ρ3 (GABRR3). We show that {GABRR1} and {G... Read More about Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3.

Multiple genes for neuropeptides and their receptors: co-evolution and physiology (1999)
Journal Article
Darlison, M. G., & Richter, D. (1999). Multiple genes for neuropeptides and their receptors: co-evolution and physiology. Trends in Neurosciences, 22(2), 81-88. https://doi.org/10.1016/S0166-2236%2898%2901333-2

It is now well established that neuropeptide receptors, which are present throughout the {CNS} and in peripheral tissues, frequently exist in a variety of different forms (called subtypes), each of which is encoded by a distinct gene. With the recent... Read More about Multiple genes for neuropeptides and their receptors: co-evolution and physiology.

Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes (1998)
Journal Article
Liu, S.-C., Parent, L., Harvey, R. J., Darlison, M. G., & Eugene, J. M. B. (1998). Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes. European Journal of Pharmacology, 354(2-3), 253-259. https://doi.org/10.1016/S0014-2999%2898%2900453-1

Chicken {GABAA} receptor β4L and β4S subunits were expressed in Xenopus oocytes by cRNA injection. Oocytes expressing either β4 subunit alone or in combination with the chicken α1 subunit were studied using the two-electrode voltage-clamp technique.... Read More about Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes.

Reliable and accurate sequencing of lambda, cosmid and P1 DNAs using modified dye terminator reaction parameters (1998)
Journal Article
Harvey, R. J., Harder, S., & Darlison, M. G. (1998). Reliable and accurate sequencing of lambda, cosmid and P1 DNAs using modified dye terminator reaction parameters. Technical tips online, 3(1), 150-152. https://doi.org/10.1016/S1366-2120%2808%2970126-0

Many laboratories still find the direct sequencing of large DNA templates (i.e. lambda, cosmid and bacteriophage P1 clones) problematic. To date, only limited amounts of sequence information, which in many cases is of poor quality, can be generated f... Read More about Reliable and accurate sequencing of lambda, cosmid and P1 DNAs using modified dye terminator reaction parameters.

Candidate gene study of eight GABAA receptor subunits in panic disorder (1997)
Journal Article
Darlison, M. G., Bailey, M., Johnson, K., Wang, Z., Crowe, R., Albrecht, B., Noyes, J. R., & Zoega, T. (1997). Candidate gene study of eight GABAA receptor subunits in panic disorder. American Journal of Psychiatry, 154(8), 1096-1100. https://doi.org/10.1176/ajp.154.8.1096

OBJECTIVE: gamma-Aminobutyric acid type A (GABAA) receptor subunit genes are candidate genes for panic disorder. Benzodiazepine agonists acting at this receptor can suppress panic attacks, and both inverse agonists and antagonists can precipitate th... Read More about Candidate gene study of eight GABAA receptor subunits in panic disorder.

In Situ Hybridization Localization of the GABAA Receptor β2S- and β2L-Subunit Transcripts Reveals Cell-Specific Splicing of Alternate Cassette Exons (1997)
Journal Article
Harvey, R., & Darlison, M. (1997). In Situ Hybridization Localization of the GABAA Receptor β2S- and β2L-Subunit Transcripts Reveals Cell-Specific Splicing of Alternate Cassette Exons. Neuroscience, 77(2), 361-369. https://doi.org/10.1016/S0306-4522%2896%2900467-8

We have recently described two variants of the chicken {GABAA} receptor β2 subunit which arise by alternative splicing of the corresponding primary gene transcript. The long form of the β2 subunit (β2L) differs from the short form (β2S) by the insert... Read More about In Situ Hybridization Localization of the GABAA Receptor β2S- and β2L-Subunit Transcripts Reveals Cell-Specific Splicing of Alternate Cassette Exons.

GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness (1996)
Book Chapter
Darlison, M. G., & Harvey, R. J. (1996). GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness. In Molecular Biology of Membrane Transport Disorders (169-180). Springer. https://doi.org/10.1007/978-1-4613-1143-0_9

Rapid chemical communication between cells in the vertebrate central nervous system is mediated by ligand-gated ion-channel receptors (also called ionotropic receptors), which are multisubunit complexes, that each contain an ion-selective channel. In... Read More about GABA-, Glycine-, and Glutamate-Gated Channels and Their Possible Involvement in Neurological and Psychiatric Illness.

Conservation of γ-Aminobutyric Acid Type A Receptor α6 Subunit Gene Expression in Cerebellar Granule Cells (1996)
Journal Article
Bahn, S., Harvey, R. J., Darlison, M. G., & Wisden, W. (1996). Conservation of γ-Aminobutyric Acid Type A Receptor α6 Subunit Gene Expression in Cerebellar Granule Cells. Journal of Neurochemistry, 66(5), 1810-1818. https://doi.org/10.1046/j.1471-4159.1996.66051810.x

The γ-aminobutyric acid type A receptor cDNAs encoding the α6 subunit homologues from chicken and goldfish have been cloned and sequenced. These proteins exhibit 83 and 75% identity, respectively, to the rat α6 polypeptide. In situ hybridization has... Read More about Conservation of γ-Aminobutyric Acid Type A Receptor α6 Subunit Gene Expression in Cerebellar Granule Cells.

Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor α1 and γ2 subunit gene cluster on chromosome 5 (1996)
Journal Article
Sander, T., Hildmann, T., Janz, D., Wienker, T. F., Bianchi, A., Bauer, G., Sailer, U., Scaramelli, A., Neitzel, H., Schmitz, B., Bailey, M. E., Beck-Mannagetta, G., Johnson, K. J., & Darlison, M. G. (1996). Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor α1 and γ2 subunit gene cluster on chromosome 5. Epilepsy Research, 23(3), 235-244. https://doi.org/10.1016/0920-1211%2895%2900098-4

Hereditary factors play a major role in the etiology of idiopathic generalized epilepsies (IGEs). The pivotal function of ionotropic γ-aminobutyric acid type A receptors (GABRs) in inhibitory neurotransmission in the mammalian central nervous system... Read More about Exclusion of linkage between idiopathic generalized epilepsies and the GABAA receptor α1 and γ2 subunit gene cluster on chromosome 5.

Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA (1995)
Journal Article
Bhandal, N. S., Ramsey, R. L., Harvey, R. J., Darlison, M. G., & Usherwood, P. N. R. (1995). Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA. Invertebrate Neuroscience, 1(3), 267-272. https://doi.org/10.1007/bf02211028

We have previously described the isolation of a complementary DNA (cDNA) from the freshwater molluscLymnaea stagnalis encoding a polypeptide that exhibits ∼50{%} identity to the {ß}-subunits of vertebrate $γ$-aminobutyric acid (GABA) type A (GABAA) r... Read More about Channel gating in the absence of agonist by a homooligomeric molluscan GABA receptor expressed inXenopus oocytes from a cloned cDNA.

The embryonal carcinoma cell line PCC7-S-AzaR: 21.21: 21.2 (clone 1009) expresses a functional GABA: 21.2A: 21.2 receptor comprising the α5, β3 and γ3 subunits: 21.2 (1995)
Journal Article
Harvey, R. J., Lobron, C., Reinhardt-Maelicke, S., Maelicke, A., & Darlison, M. G. (1995). The embryonal carcinoma cell line PCC7-S-AzaR: 21.21: 21.2 (clone 1009) expresses a functional GABA: 21.2A: 21.2 receptor comprising the α5, β3 and γ3 subunits: 21.2. Behavioural Pharmacology, 6(SUPPLEMENT 1), 119. https://doi.org/10.1097/00008877-199505001-00138

Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes (1995)
Journal Article
Albrecht, B. E., & Darlison, M. G. (1995). Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes. Neuroscience Letters, 189(3), 155-158. https://doi.org/10.1016/0304-3940%2895%2911479-g

We have amplified partial complementary {DNAs} for the chicken γ-aminobutyric acid type C (GABAC) receptor ρ1 and ρ2 subunits using the polymerase chain reaction. These nucleotide sequences have been utilized to design specific oligonucleotide probes... Read More about Localization of the ρ1- and ρ2-subunit messenger RNAs in chick retina by in situ hybridization predicts the existence of γ-aminobutyric acid type C receptor subtypes.