Skip to main content

Research Repository

Advanced Search

Outputs (68)

Implementing Supported Self-Management in Community-Based Stroke Care: A Secondary Analysis of Nurses’ Perspectives (2020)
Journal Article
Kidd, L., Booth, J., Lawrence, M., & Rowat, A. (2020). Implementing Supported Self-Management in Community-Based Stroke Care: A Secondary Analysis of Nurses’ Perspectives. Journal of Clinical Medicine, 9(4), Article 985. https://doi.org/10.3390/jcm9040985

The provision of supported self‐management (SSM) is recommended in contemporary guidelines to address the longer‐term needs and outcomes of stroke survivors and their families, yet its implementation across stroke pathways has been inconsistent. Thi... Read More about Implementing Supported Self-Management in Community-Based Stroke Care: A Secondary Analysis of Nurses’ Perspectives.

A review of the impact of utilising electronic medical records for clinical research recruitment (2019)
Journal Article
Lai, Y. S., & Afseth, J. D. (2019). A review of the impact of utilising electronic medical records for clinical research recruitment. Clinical Trials, 16(2), 194-203. https://doi.org/10.1177/1740774519829709

Introduction:
Recruitment is an important aspect of clinical research, as poor recruitment could undermine the scientific value of a trial or delay the development process of new treatments. The development of electronic medical records provides a n... Read More about A review of the impact of utilising electronic medical records for clinical research recruitment.

Diagnostic accuracy of a pH stick, modified to detect gastric lipase, to confirm the correct placement of nasogastric tubes (2018)
Journal Article
Rowat, A. M., Graham, C., & Dennis, M. (2018). Diagnostic accuracy of a pH stick, modified to detect gastric lipase, to confirm the correct placement of nasogastric tubes. BMJ Open Gastroenterology, 5(1), Article e000218. https://doi.org/10.1136/bmjgast-2018-000218

Objective The correct placement of a nasogastric feeding tube is usually confirmed by establishing that an aspirate is acidic using a pH stick. However, antacid medication and achlorhydria can cause false negative pH tests that may delay feeding and... Read More about Diagnostic accuracy of a pH stick, modified to detect gastric lipase, to confirm the correct placement of nasogastric tubes.

Study to determine the likely accuracy of pH testing to confirm nasogastric tube placement (2018)
Journal Article
Rowat, A. M., Graham, C., Dennis, M., & Rowat, A. (2018). Study to determine the likely accuracy of pH testing to confirm nasogastric tube placement. BMJ Open Gastroenterology, 5(1), Article e000211. https://doi.org/10.1136/bmjgast-2018-000211

Objective To establish the likely accuracy of pH testing to identify gastric aspirates at different pH cut-offs to confirm nasogastric tube placement.
Methods This prospective observational study included a convenience sample of adult patients who h... Read More about Study to determine the likely accuracy of pH testing to confirm nasogastric tube placement.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

Interventions for maintaining nasogastric feeding after stroke: An integrative review of effectiveness and acceptability (2017)
Journal Article
Mahoney, C., & Veitch, L. (2018). Interventions for maintaining nasogastric feeding after stroke: An integrative review of effectiveness and acceptability. Journal of Clinical Nursing, 27(3-4), e427-e436. https://doi.org/10.1111/jocn.14013

Aims and objectives
To investigate the effectiveness and acceptability of interventions for maintaining nasogastric tubes (NGT) in adult stroke patients.
Background
Internationally, incidence of Cerebral Vascular Disease (CVD) continues to increas... Read More about Interventions for maintaining nasogastric feeding after stroke: An integrative review of effectiveness and acceptability.

Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people (Review) (2015)
Journal Article
Hooper, L., Abdelhamid, A., Attreed, N. J., Campbell, W. W., Channell, A. M., Chassagne, P., Culp, K. R., Fletcher, S. J., Fortes, M. B., Fuller, N., Gaspar, P. M., Gilbert, D. J., Heathcote, A. C., Kafri, M. W., Kajii, F., Lindner, G., Mack, G. W., Mentes, J. C., Merlani, P., Needham, R. A., …Hunter, P. (2015). Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people (Review). Cochrane Database of Systematic Reviews, 1(4), Article CD009647. https://doi.org/10.1002/14651858.CD009647.pub2

Background
There is evidence that water-loss dehydration is common in older people and associated with many causes of morbidity and mortality.
However, it is unclear what clinical symptoms, signs and tests may be used to identify early dehydration... Read More about Clinical symptoms, signs and tests for identification of impending and current water-loss dehydration in older people (Review).

Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit (2005)
Journal Article
Jones, A. K., Marshall, J., Blake, A. D., Buckingham, S. D., Darlison, M. G., & Sattelle, D. B. (2005). Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit. Invertebrate Neuroscience, 5(3-4), 147-155. https://doi.org/10.1007/s10158-005-0007-6

The cloning, sequencing and functional expression of Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor (nAChR) subunit is described. This subunit shows 80% identity with the Drosophila melanogaster Dβ1 and 92% identi... Read More about Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit.

Consequences of the Evolution of the GABAA Receptor Gene Family (2005)
Journal Article
Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the Evolution of the GABAA Receptor Gene Family. Cellular and Molecular Neurobiology, 25(3-4), 607-624. https://doi.org/10.1007/s10571-005-4004-4

1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous sy... Read More about Consequences of the Evolution of the GABAA Receptor Gene Family.

Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick (2005)
Journal Article
Bock, J., Thode, C., Hannemann, O., Braun, K., & Darlison, M. (2005). Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick. Neuroscience, 133(3), 625-633. https://doi.org/10.1016/j.neuroscience.2005.02.048

We have cloned a full-length complementary {DNA} from the chicken (Gallus gallus domesticus), which encodes a polypeptide that exhibits ∼75% identity to the product of the mammalian gene Arc (activity-regulated cytoskeleton-associated protein), also... Read More about Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick.

The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus (2004)
Journal Article
Thode, C., Bock, J., Braun, K., & Darlison, M. (2005). The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus. Neuroscience, 130(3), 611-617. https://doi.org/10.1016/j.neuroscience.2004.10.015

The immediate-early gene zenk (an acronym for the avian orthologue of the mammalian genes zif-268, egr-1, ngfi-a and krox-24) has been extensively employed, in studies on oscine birds, as a marker of neuronal activity to reveal forebrain structures t... Read More about The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus.

Antioxidant and cytoprotective responses to redox stress (2004)
Journal Article
Mathers, J., Fraser, J. A., McMahon, M., Saunders, R. D. C., Hayes, J. D., & McLellan, L. I. (2004). Antioxidant and cytoprotective responses to redox stress. Biochemical Society symposia, 71, 157-176. https://doi.org/10.1042/bss0710157

Aerobic cells produce reactive oxygen species as a consequence of normal cellular metabolism, and an array of antioxidant systems are in place to maintain the redox balance. When the redox equilibrium of the cell is upset by pro-oxidant environmental... Read More about Antioxidant and cytoprotective responses to redox stress.

Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form (2001)
Journal Article
Fraser, J. A., Saunders, R. D. C., & McLellan, L. I. (2002). Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form. Journal of Biological Chemistry, 277(2), 1158-1165. https://doi.org/10.1074/jbc.m106683200

Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a catalytic (GCLC) and modifier (GCLM) subunit. The existence of a modifier subunit in invertebrates has not been described to dat... Read More about Drosophila melanogasterGlutamate-Cysteine Ligase Activity Is Regulated by a Modifier Subunit with a Mechanism of Action Similar to That of the Mammalian Form.

Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish (2001)
Journal Article
Pohl, S., Darlison, M. G., Clarke, W., Lederis, K., & Richter, D. (2001). Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish. European Journal of Pharmacology, 430(2-3), 193-202. https://doi.org/10.1016/S0014-2999%2801%2901391-7

Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacology of their cognate receptors. Here we report the isolation and functional e... Read More about Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish.

Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit (2001)
Journal Article
Forster, I. C., Harvey, R. J., Darlison, M. G., & Benson, J. A. (2001). Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit. European Journal of Pharmacology, 419(1), 1-7. https://doi.org/10.1016/S0014-2999%2801%2900964-5

The functional pharmacology of receptors composed of the chicken brain {GABAA} receptor γ4 subunit and the mammalian {GABAA} receptor α3 and β2 subunits was studied by heterologous expression in Xenopus laevis oocytes using the two electrode voltage-... Read More about Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit.

Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3 (1999)
Journal Article
Bailey, M. E., Albrecht, B. E., Johnson, K. J., & Darlison, M. G. (1999). Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. BBA - Gene Structure and Expression, 1447(2-3), 307-312. https://doi.org/10.1016/s0167-4781%2899%2900167-0

{GABAC} receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: ρ1 (GABRR1), ρ2 (GABRR2) and ρ3 (GABRR3). We show that {GABRR1} and {G... Read More about Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3.

Multiple genes for neuropeptides and their receptors: co-evolution and physiology (1999)
Journal Article
Darlison, M. G., & Richter, D. (1999). Multiple genes for neuropeptides and their receptors: co-evolution and physiology. Trends in Neurosciences, 22(2), 81-88. https://doi.org/10.1016/S0166-2236%2898%2901333-2

It is now well established that neuropeptide receptors, which are present throughout the {CNS} and in peripheral tissues, frequently exist in a variety of different forms (called subtypes), each of which is encoded by a distinct gene. With the recent... Read More about Multiple genes for neuropeptides and their receptors: co-evolution and physiology.

Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes (1998)
Journal Article
Liu, S.-C., Parent, L., Harvey, R. J., Darlison, M. G., & Eugene, J. M. B. (1998). Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes. European Journal of Pharmacology, 354(2-3), 253-259. https://doi.org/10.1016/S0014-2999%2898%2900453-1

Chicken {GABAA} receptor β4L and β4S subunits were expressed in Xenopus oocytes by cRNA injection. Oocytes expressing either β4 subunit alone or in combination with the chicken α1 subunit were studied using the two-electrode voltage-clamp technique.... Read More about Chicken GABAA receptor β4 subunits form robust homomeric GABA-gated channels in Xenopus oocytes.