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The Influence of Menstruation on Training Schedules in Well-Trained and Elite Female Mountain Bike, Road and Cyclocross Athletes (2023)
Journal Article
Aitkenhead, R., Kirkwood, L., Florida-James, G., & Ingram-Sills, L. (2023). The Influence of Menstruation on Training Schedules in Well-Trained and Elite Female Mountain Bike, Road and Cyclocross Athletes. Journal of Applied Sports Sciences, 2, 62-75. https://doi.org/10.37393/JASS.2023.02.6

Female physiology is unique and driven by fluctuations in sex hormones that regulate the menstrual cycle. These hormones present myriad mechanisms that may influence physiological systems, potentially implicating exercise performance. However, resear... Read More about The Influence of Menstruation on Training Schedules in Well-Trained and Elite Female Mountain Bike, Road and Cyclocross Athletes.

CIE Report: Bridging the gap (2023)
Report
Buchmann, A., Backhaus, C., Anderman, M., Plant O'Toole, E., Weaver, M., Neye, C., & Florida-James, G. (2023). CIE Report: Bridging the gap. Cycling Industries Europe

Ex Vivo treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against in vitro exposure to FEC-T chemotherapy (2023)
Journal Article
Mclaughlin, M., Hesketh, K. L., Horgan, S. L., Florida-James, G., Cocks, M., Strauss, J. A., & Ross, M. (2023). Ex Vivo treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against in vitro exposure to FEC-T chemotherapy. Frontiers in Physiology, 14, Article 1079983. https://doi.org/10.3389/fphys.2023.1079983

Background: Chemotherapy treatment for breast cancer associates with well-documented cardiovascular detriments. Exercise has shown promise as a potentially protective intervention against cardiac toxicity. However, there is a paucity of evidence for... Read More about Ex Vivo treatment of coronary artery endothelial cells with serum post-exercise training offers limited protection against in vitro exposure to FEC-T chemotherapy.

The future directions and trends for off road e-bike use and impact in Great Britain (2023)
Report
Ingram-Sills, L., Campbell, T., Kirkwood, L., & Florida-James, G. (2023). The future directions and trends for off road e-bike use and impact in Great Britain. British Cycling

The introduction of e-bikes into the cycling industry has resulted in a growing market, with sales demonstrating an increase exponentially over the last five years. Globally it is predicted that e-bikes will reach and potentially surpass 130 million... Read More about The future directions and trends for off road e-bike use and impact in Great Britain.

The Effects of Menstrual Cycle Phases on Running Repeated Sprint Ability (2022)
Journal Article
Di Nicola, S., Ferrier, B., Florida-James, G., & Kavaliauskas, M. (2022). The Effects of Menstrual Cycle Phases on Running Repeated Sprint Ability. International Journal of Strength and Conditioning, 2(1), https://doi.org/10.47206/ijsc.v2i1.137

Female participation in regular sport activities has increased in recent years, yet their representation in sports and exercise science literature remains low. This can be partly attributed to the complexities associated with the menstrual cycle (MC)... Read More about The Effects of Menstrual Cycle Phases on Running Repeated Sprint Ability.

Influence of menstruation on training schedules in female mountain bike athletes (2022)
Presentation / Conference
Aitkenhead, R., Kirkwood, L., Florida-James, G., & Ingram-Sills, L. (2022, April). Influence of menstruation on training schedules in female mountain bike athletes. Poster presented at The Biomedical Basis of Elite Performance 2022 (The Physiological Society), Nottingham

Female participation in elite sport is rising, the most recent Olympic games, Tokyo 2020, was the most gender-balanced games in history but research within female athletes is lacking. This study investigated if different phases of the menstrual cycle... Read More about Influence of menstruation on training schedules in female mountain bike athletes.

Trail use, motivations and environmental attitudes of 3780 European mountain bikers: what is sustainable? (2021)
Journal Article
Campbell, T., Kirkwood, L., McLean, G., Torsius, M., & Florida-James, G. (2021). Trail use, motivations and environmental attitudes of 3780 European mountain bikers: what is sustainable?. International Journal of Environmental Research and Public Health, 18(24), Article 12971. https://doi.org/10.3390/ijerph182412971

Background: The extent to which mountain biking impacts upon the environment is largely determined by rider behaviours. The purpose of this study was to gain a better understanding of how mountain bikers interact with the natural environment and expl... Read More about Trail use, motivations and environmental attitudes of 3780 European mountain bikers: what is sustainable?.

Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic (2021)
Journal Article
Mclaughlin, M., Florida-James, G., & Ross, M. (2021). Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic. Vascular Biology, 3(1), R106-R120. https://doi.org/10.1530/VB-21-0013

Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact o... Read More about Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic.

Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age (2021)
Journal Article
Lithgow, H., Florida‐James, G., Ross, M., Duncan, G., & Leggate, M. (2021). Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age. Experimental Physiology, 106(7), 1460-1469. https://doi.org/10.1113/ep089480

Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR). Exercise has been shown to influence the activity and availability of the VDR. This study aimed to investigate the effect... Read More about Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age.

Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration (2021)
Journal Article
Kirkwood, L., Ingram-Sills, L., Taylor, M. D., Malone, E., & Florida-James, G. (2021). Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration. International Journal of Environmental Research and Public Health, 18(9), Article 4603. https://doi.org/10.3390/ijerph18094603

Introduction: Understanding the sport-specific immune response elicited during both training and competition is imperative to maximise athlete health and performance. Despite a growing population of professional enduro mountain bike athletes, little... Read More about Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration.

Enduro World Series (EWS) Mountain Biking Injuries: A 2-year Prospective Study of 2010 Riders (2020)
Journal Article
Palmer, D., Florida-James, G., & Ball, C. (2020). Enduro World Series (EWS) Mountain Biking Injuries: A 2-year Prospective Study of 2010 Riders. International Journal of Sports Medicine, https://doi.org/10.1055/a-1320-1116

The sport of Enduro is the newest International Cycling Union sanctioned discipline in mountain biking. There are a number of studies reporting mountain biking injury to date however there are none detailing injuries in Enduro. The aim of the present... Read More about Enduro World Series (EWS) Mountain Biking Injuries: A 2-year Prospective Study of 2010 Riders.

The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males (2019)
Presentation / Conference
Leggate, M., Florida-James, G., Ross, M., Jurevicius, M., Duncan, G., & Lithgow, H. (2019, December). The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males. Presented at Future Physiology, Liverpool, UK

A low vitamin D status has been identified as an association risk factor in the etiology of numerous chronic diseases, with older adults identified as generally more deficient than younger populations. Exercise has been shown to act as a direct and i... Read More about The effects of age and acute aerobic and resistance exercise on circulating T lymphocyte vitamin D receptor (VDR) expression in healthy males.

Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure (2019)
Journal Article
Kirkwood, L. A., Taylor, M. D., Ingram, L. A., Malone, E., & Florida-James, G. D. (2019). Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure. Journal of Science and Cycling, 8(1), 18-25. https://doi.org/10.28985/1906.jsc.04

Limited information is currently available regarding the hand-arm vibration (HAV) exposure 5 for professional off-road cyclists. Previous reports have suggested that commuting and 6 recreational cyclists are at risk of exceeding exposure limit values... Read More about Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure.

Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. (2019)
Journal Article
Montgomery, R., Paterson, A., Williamson, C., Florida-James, G., & Ross, M. D. (2019). Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. Frontiers in Physiology, https://doi.org/10.3389/fphys.2019.00447

Endothelial progenitor cells (EPCs) are a vasculogenic subset of progenitors, which play a key role in maintenance of endothelial integrity. These cells are exercise-responsive, and thus exercise may play a key role in vascular repair and maintenance... Read More about Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men..

The effect of acute exercise on T cell vitamin D receptor (VDR) expression in young and older males (2018)
Presentation / Conference
Leggate, M., Lithgow, H., Florida-James, G., & Barlow, P. (2018, July). The effect of acute exercise on T cell vitamin D receptor (VDR) expression in young and older males. Presented at 23rd Annual Congress of the European College of Sport Science (ECSS), Dublin, Ireland

A low vitamin D status has been identified as an association risk factor in the etiology of numerous chronic diseases, with older adults identified as generally more deficient than younger populations. Exercise has been shown to act as a direct and i... Read More about The effect of acute exercise on T cell vitamin D receptor (VDR) expression in young and older males.

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men (2018)
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018). Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), Article e13697. https://doi.org/10.14814/phy2.13697

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T-cells (angiogenic T-cells; TANG) possess highly angiogenic capa... Read More about Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men.

Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment (2018)
Journal Article
Boukelia, Z., Gomes, E. C., & Florida-James, G. D. (2018). Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment. Oxidative Medicine and Cellular Longevity, 2018, Article 3402143. https://doi.org/10.1155/2018/3402143

Purpose. The purpose of this study was to investigate the physiological and immunological response of highly trained runners to an intense bout of exercise performed at two different times of day, in a hot, humid environment. Methods. Using a crossov... Read More about Diurnal Variation in Physiological and Immune Responses to Endurance Sport in Highly Trained Runners in a Hot and Humid Environment.

The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults (2018)
Journal Article
Lithgow, H. M., Florida-James, G., & Leggate, M. (2018). The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults. Physiological Reports, 6(9), Article e13684. https://doi.org/10.14814/phy2.13684

High intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. Th... Read More about The combined effect of high-intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults.

Anticipation and the cortisol awakening response within a dynamic psychosocial work environment (2018)
Journal Article
Campbell, T. G., Westbury, T., Davison, R., & Florida-James, G. (2018). Anticipation and the cortisol awakening response within a dynamic psychosocial work environment. International Journal of Stress Prevention and Wellbeing, 2, Article 2

The cortisol awakening response (CAR) is a distinct element of the diurnal pattern of cortisol release, believed to be partly driven by the anticipation of the demands of the upcoming day. Although evidence suggests that the response may be associate... Read More about Anticipation and the cortisol awakening response within a dynamic psychosocial work environment.

Physiological characteristics and performance in elite enduro mountain biking (2017)
Journal Article
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2017). Physiological characteristics and performance in elite enduro mountain biking. Journal of Science and Cycling, 6(2), 13-21. https://doi.org/10.28985/171231.jsc.09

Enduro mountain bike racing is composed of several timed predominantly downhill race stages linked by time restricted, non-competitive transition stages. This study aimed to 1) detail and compare the laboratory assessed physiological characteristics... Read More about Physiological characteristics and performance in elite enduro mountain biking.

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Anticipation and the cortisol awakening response within a dynamic psychosocial work environment (2017)
Presentation / Conference
Campbell, T., Westbury, T., Davison, R., & Florida-James, G. (2017, October). Anticipation and the cortisol awakening response within a dynamic psychosocial work environment. Poster presented at Society for Psychophysiological Research - 57th Annual Meeting, Vienna, Austria

The cortisol awakening response (CAR) is a distinct element of the diurnal pattern of cortisol release, believed to be partly driven by the anticipation of the demands of the upcoming day. Although evidence suggests that the response may be associate... Read More about Anticipation and the cortisol awakening response within a dynamic psychosocial work environment.

A case study investigation or the autonomic and endocrine response to psychosocial demand in the workplace. (2017)
Presentation / Conference
Campbell, T., Westbury, T., Davison, R., & Florida-James, G. (2017, July). A case study investigation or the autonomic and endocrine response to psychosocial demand in the workplace. Paper presented at 38th Annual Conferenec of the Stress and Anxiety Research Society

Purpose: To investigate the effect of acute day-to-day psychosocial work characteristics upon the autonomic and endocrine stress response. Design: The study employed a single case study design to measure 24 hour ambulatory heart rate variability (... Read More about A case study investigation or the autonomic and endocrine response to psychosocial demand in the workplace..

Assessment of occupational stress in higher education employees through the cortisol awakening response. (2017)
Presentation / Conference
Campbell, T., Westbury, T., Davison, R., & Florida-James, G. (2017, July). Assessment of occupational stress in higher education employees through the cortisol awakening response. Poster presented at STAR Conference 2017

Purpose: Although the cortisol awakening response (CAR) has been used to investigate occupational stress among various professions there are limitations to the interpretation of findings obtained through cross-sectional approaches. The aim of this st... Read More about Assessment of occupational stress in higher education employees through the cortisol awakening response..

The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults (2017)
Presentation / Conference
Leggate, M., Lithgow, H., & Florida-James, G. (2017, May). The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults. Poster presented at Cell Symposia: Exercise Metabolism, Gothenburg, Sweden

The aim of this study was to investigate if there was a synergistic effect of high intensity intermittent training (HIIT) and vitamin D3 supplementation on glycaemic control. Twenty participants (age, 34±9y; BMI, 31.4±2.8 kg·m-2) completed 6 weeks HI... Read More about The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults.

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes (2016)
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956

Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is pr... Read More about Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.

Diurnal physiological and immunological responses to a 10-km run in highly trained athletes in an environmentally controlled condition of 6 °C (2016)
Journal Article
Boukelia, B., Fogarty, M. C., Davison, R. C. R., & Florida-James, G. D. (2016). Diurnal physiological and immunological responses to a 10-km run in highly trained athletes in an environmentally controlled condition of 6 °C. European Journal of Applied Physiology, 117(1), 1-6. https://doi.org/10.1007/s00421-016-3489-5

Purpose The Clara cell protein CC16, secreted from Clara cells in the lung, is discussed as a potential biomarker for toxic effects on the airways. An increased concentration of CC16 in serum may be caused by increased permeability of the lungs. T... Read More about Diurnal physiological and immunological responses to a 10-km run in highly trained athletes in an environmentally controlled condition of 6 °C.

A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells (2016)
Journal Article
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), 1253-1264. https://doi.org/10.1113/ep085771

New Findings What is the central question of the study? Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise? What is the main finding and its importance? Our study reveals that TANG cells are redistributed i... Read More about A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells.

An exploratory study of the relationship between psychosocial hazard and ambulatory physiological response in higher education employees (2016)
Journal Article
Campbell, T. G., Davison, R., Florida-James, G., & Westbury, T. (2016). An exploratory study of the relationship between psychosocial hazard and ambulatory physiological response in higher education employees. International Journal of Workplace Health Management, 9(3), 360-374. https://doi.org/10.1108/IJWHM-11-2015-0068

Purpose: as exposure to psychosocial hazard at work represents a substantial risk factor for employee health in many modern occupations, being able to accurately assess how employees cope with their working environment is crucial. As the workplace is... Read More about An exploratory study of the relationship between psychosocial hazard and ambulatory physiological response in higher education employees.

High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number (2016)
Presentation / Conference
Ross, M. D., Malone, E., Simpson, R., & Florida-James, G. (2016, May). High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number. Poster presented at American College of Sports Medicine (ACSM) Annual Congress, Boston

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related decline in blood vessel number and function; however the mechanisms are not... Read More about High Cardiorespiratory Fitness Alleviates the Negative Impact of Increasing Sitting Time on CD31+ T-Cell Number.

Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers (2016)
Journal Article
Simpson, R. J., Graham, S. M., Connaboy, C., Clement, R., Pollonini, L., & Florida-James, G. D. (2017). Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers. Applied Ergonomics, 58, 566-572. https://doi.org/10.1016/j.apergo.2016.04.010

We developed a standardized laboratory treadmill protocol for assessing physiological responses to a simulated backpack load-carriage task in trained soldiers, and assessed the efficacy of blood lactate thresholds (LTs) and economy in predicting futu... Read More about Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers.

Exercise and the Immune System (2016)
Book Chapter
Gomes, E. C., & Florida-James, G. (2016). Exercise and the Immune System. In C. Esser (Ed.), Environmental Influences on the Immune System (127-152). Vienna, Austria: Springer. https://doi.org/10.1007/978-3-7091-1890-0_6

This chapter is divided into three major parts. The first part covers how exercise is associated with respiratory infection. Exercise’s effect on mucosal immunity, allergic rhinitis and airway inflammation is discussed as well as how certain viruses... Read More about Exercise and the Immune System.

The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression (2015)
Presentation / Conference
Ross, M., Malone, E., Simpson, R., & Florida-James., G. (2015, May). The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression. Poster presented at American College of Sports Medicine (ACSM) Annual Congress, Boston

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Regular exercise is known to offset the age-related decline in blood vessel number and function; however the mechanisms are not... Read More about The Influence of Age, and Cardiorespiratory Fitness on Circulating Angiogenic T Cells and CXCR4 expression.

The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. (2015)
Conference Proceeding
Ross, M. D., Malone, E. M., Simpson, R. J., & Florida-James, G. (2015). The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Additionally, regular exercise is known to offset the age-related decline in blood vessel number and function. Circulating angio... Read More about The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression..

Assessing the link between stress and retention and the existence of barriers to support service use within HE (2015)
Journal Article
Campbell Casey, S., Westbury, T., Florida-James, G., Harris, P., Campbell, S. A., Westbury, T., & Florida-James, G. (2016). Assessing the link between stress and retention and the existence of barriers to support service use within HE. Journal of Further and Higher Education, 40(6), 824-845. https://doi.org/10.1080/0309877x.2015.1014316

Students suffer from stress as a result of many factors, including educational unpreparedness, financial strain and inability to integrate socially. This mixed methods study aimed to investigate stress levels of undergraduate students in a post-1992,... Read More about Assessing the link between stress and retention and the existence of barriers to support service use within HE.

Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise (2015)
Journal Article
Florida-James, G. D., Ingram, L. A., Simpson, R. J., Malone, E., & Florida-James, G. (2015). Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise. Brain, Behavior, and Immunity, 47, 100-108. https://doi.org/10.1016/j.bbi.2014.12.018

Sleep disruption and deprivation are common in contemporary society and have been linked with poor health, decreased job performance and increased life-stress. The rapid redeployment of lymphocytes between the blood and tissues is an archetypal featu... Read More about Sleep disruption and its effect on lymphocyte redeployment following an acute bout of exercise.

Lung Inflammation, oxidative stress and air pollution. (2014)
Book Chapter
Gomes, E. C., & Florida-James, G. (2014). Lung Inflammation, oxidative stress and air pollution. In K. C. Ong (Ed.), Lung InflammationInTech. https://doi.org/10.5772/58252

This is a very relevant chapter in the context of “Lung Inflammation” because it details and discusses an important theme in this area: air pollution. The analyses of epidemiological studies, conducted in various urban centres, have provided coherent... Read More about Lung Inflammation, oxidative stress and air pollution..

Injury occurrence and mood states during a desert ultramarathon (2012)
Journal Article
Graham, S. M., McKinley, M., Chris, C. C., Westbury, T., Baker, J. S., Kilgore, L., & Florida-James, G. (2012). Injury occurrence and mood states during a desert ultramarathon. Clinical Journal of Sport Medicine, 22(6), 462-466. https://doi.org/10.1097/jsm.0b013e3182694734

Objective: To describe injuries and illnesses presented and profile mood states and sleep patterns during a desert environment ultramarathon. Design: Prospective study gathering data on mood states and injury patterns. Setting: Gobi Desert, Mongoli... Read More about Injury occurrence and mood states during a desert ultramarathon.

Effect of vitamin supplementation on lung injury and running performance in a hot, humid, and ozone-polluted environment: Antioxidants on lung injury and performance (2011)
Journal Article
Gomes, E. C., Allgrove, J. E., Florida-James, G., & Stone, V. (2011). Effect of vitamin supplementation on lung injury and running performance in a hot, humid, and ozone-polluted environment: Antioxidants on lung injury and performance. Scandinavian Journal of Medicine and Science in Sports, 21(6), e452-e460. https://doi.org/10.1111/j.1600-0838.2011.01366.x

In this study, the effect of vitamin C and E supplementation on lung injury and performance of runners were analyzed. Using a randomized, double-blinded, crossover design, nine runners participated in two experimental trials: a 2-week Vitamin trial (... Read More about Effect of vitamin supplementation on lung injury and running performance in a hot, humid, and ozone-polluted environment: Antioxidants on lung injury and performance.

Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run (2011)
Journal Article
Gomes, E. C., Stone, V., & Florida-James, G. (2011). Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run. European Journal of Applied Physiology, 111(9), 2089-2097. https://doi.org/10.1007/s00421-011-1839-x

To investigate the acute effect of a hot, humid and ozone-polluted (O3) environment on lung inflammation and oxidative tress of runners performing 8 km time trial run. Using a single-blinded randomized design, 10 male athletes (mean V˙O2max = 64.4 ml... Read More about Impact of heat and pollution on oxidative stress and CC16 secretion after 8 km run.

Perceived exertion and heart rate models for estimating metabolic workload in elite British soldiers performing a backpack load-carriage task (2010)
Journal Article
Simpson, R. J., Graham, S. M., Florida-James, G. D., Connaboy, C., Clement, R., & Jackson, A. S. (2010). Perceived exertion and heart rate models for estimating metabolic workload in elite British soldiers performing a backpack load-carriage task. Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme, 35(5), 650-656. https://doi.org/10.1139/h10-053

Identifying field measures to estimate backpack load-carriage work intensity in elite soldiers is of interest to the military. This study developed rating of perceived exertion (RPE) and heart rate models to define metabolic workload for a backpack l... Read More about Perceived exertion and heart rate models for estimating metabolic workload in elite British soldiers performing a backpack load-carriage task.

The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum (2010)
Journal Article
Florida-James, G. D., McFarlin, B. K., O’Connor, D. P., Simpson, R. J., Booth, S., Florida-James, G., …Simpson, R. J. (2010). The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum. European Journal of Applied Physiology, 110(6), 1259-1268. https://doi.org/10.1007/s00421-010-1616-2

Acute exercise alters the surface expression of toll-like receptors (TLRs) and HLA.DR on blood monocytes, which could transiently compromise immunity. As serum factors might be responsible, we examined the effects of autologous post-exercise serum ex... Read More about The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum.

Investigating performance and lung function in a hot, humid and ozone-polluted environment (2010)
Journal Article
Gomes, E. C., Stone, V., & Florida-James, G. (2010). Investigating performance and lung function in a hot, humid and ozone-polluted environment. European Journal of Applied Physiology, 110(1), 199-205. https://doi.org/10.1007/s00421-010-1485-8

Large urbanized areas, where sports events take place, have a polluted environment and can also reach high temperatures and humidity levels. The aim of this study was to investigate the impact of a hot, humid and ozone-polluted (O3) environment on (1... Read More about Investigating performance and lung function in a hot, humid and ozone-polluted environment.

Metabolic Differences Between Backpack Walking And Running At A Fixed Treadmill Velocity In 'Elite" British Soldiers: A Pilot Study: 708 (2009)
Journal Article
Graham, S. M., Florida-James, G. D., Connaboy, C., Clement, R., & Simpson, R. J. (2009). Metabolic Differences Between Backpack Walking And Running At A Fixed Treadmill Velocity In 'Elite" British Soldiers: A Pilot Study: 708. Medicine and Science in Sports and Exercise, 41(Supplement 1), 57. https://doi.org/10.1249/01.mss.0000353442.94255.27

Soldiers who serve in the "elite" units of the British Army are expected to "speed march" carrying heavy backpack loads, which involves a combination of both running and fast walking movements as an individual and in groups. It is generally accepted... Read More about Metabolic Differences Between Backpack Walking And Running At A Fixed Treadmill Velocity In 'Elite" British Soldiers: A Pilot Study: 708.

Resting Blood Lymphocytes Are Activated By Autologous Serum After A 40km Cycling Time Trial: 542 (2009)
Journal Article
Simpson, R. J., Bartlett, D. B., Booth, S., Florida-James, G. D., & McFarlin, B. K. (2009). Resting Blood Lymphocytes Are Activated By Autologous Serum After A 40km Cycling Time Trial: 542. Medicine and Science in Sports and Exercise, 41(Supplement 1), 7. https://doi.org/10.1249/01.mss.0000353277.01938.3c

PURPOSE: Although it is known that peripheral blood lymphocytes display an activated phenotype immediately after an acute bout of high-intensity exercise, it is not known if these lymphocytes are activated by exercise or whether this is due to a mobi... Read More about Resting Blood Lymphocytes Are Activated By Autologous Serum After A 40km Cycling Time Trial: 542.

Reliability Study Of The Technique To Assess Upper Respiratory Airway Inflammation In A Polluted Environment: 1695 (2009)
Journal Article
Gomes, E. C., Florida-James, G., & Stone, V. (2009). Reliability Study Of The Technique To Assess Upper Respiratory Airway Inflammation In A Polluted Environment: 1695. Medicine and Science in Sports and Exercise, 41(Supplement 1), 99. https://doi.org/10.1249/01.mss.0000354860.20764.82

Airway inflammation can be detected by an increased influx of inflammatory cells, such as neutrophils, as well as increased expression of inflammatory markers, which include interleukin-6 (IL-6) and Clara cell protein (CC16). When an individual is ex... Read More about Reliability Study Of The Technique To Assess Upper Respiratory Airway Inflammation In A Polluted Environment: 1695.

Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise (2008)
Journal Article
Simpson, R. J., Cosgrove, C., Ingram, L. A., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2008). Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise. Brain, Behavior, and Immunity, 22(4), 544-551. https://doi.org/10.1016/j.bbi.2007.11.002

Senescent T-lymphocytes are antigen-experienced cells that express the killer-cell lectin-like receptor G1 (KLRG1) and/or CD57; fail to clonally expand following further antigenic stimulation and prevail in the resting blood of older adults compared... Read More about Senescent T-lymphocytes are mobilised into the peripheral blood compartment in young and older humans after exhaustive exercise.

Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise (2007)
Journal Article
Campbell, J. P., Guy, K., Cosgrove, C., Florida-James, G., & Simpson, R. J. (2008). Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain, Behavior, and Immunity, 22(3), 375-380. https://doi.org/10.1016/j.bbi.2007.09.001

Cytotoxic T-lymphocytes co-express the T-cell receptor, CD3 and the MHC I restricted antigen CD8. Although total CD8 expression is often used to identify CD8+ T-cells in blood, errors are associated with this method as some CD3 negative natural kille... Read More about Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise.

Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. (2007)
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., Black, J., Ross, J., & Guy, K. (2007). Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Research in Sports Medicine, 15, 157-174. https://doi.org/10.1080/15438620701405339

The lymphocytopenia that occurs during the recovery stage of exercise may be a result of apoptosis through an increased expression of CD95, a loss of the complement regulatory proteins CD55 and CD59, or both. Trained subjects completed intensive, mod... Read More about Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans..

High-Intensity Exercise Mobilises Senescent T-lymphocytes into the Peripheral Blood Compartment in Young and Old Subjects: 781 (2007)
Journal Article
Simpson, R. J., Cosgrove, C., Florida-James, G. D., Whyte, G. P., Pircher, H., & Guy, K. (2007). High-Intensity Exercise Mobilises Senescent T-lymphocytes into the Peripheral Blood Compartment in Young and Old Subjects: 781. Medicine and Science in Sports and Exercise, 39(Supplement), S61. https://doi.org/10.1249/01.mss.0000273140.61651.0b

T-cell senescence occurs during aging as a consequence of chromosome telomere shortening in response to repetitive antigenic stimulation. Senescent T-lymphocytes normally exhibit a “memory” phenotype (i.e. CD62L-/CD45RA-/CD45RO+) and express CD57 and... Read More about High-Intensity Exercise Mobilises Senescent T-lymphocytes into the Peripheral Blood Compartment in Young and Old Subjects: 781.

Physiological and Anthropometrical Indicators of Backpack Running Performance in ??Elite?? British Soldiers: 1384 (2007)
Journal Article
Graham, S. M., Simpson, R. J., Clement, R., & Florida-James, G. D. (2007). Physiological and Anthropometrical Indicators of Backpack Running Performance in ??Elite?? British Soldiers: 1384. Medicine and Science in Sports and Exercise, 39(Supplement), S199. https://doi.org/10.1249/01.mss.0000273743.89788.1f

PURPOSE: To identify indicators of backpack running performance in “elite” British soldiers using an extensive range of physiological and anthropometrical variables. METHODS: Thirteen male soldiers (mean ± SD: Age: 26 ± 4 yrs; VO2peak: 55.1 ± 5.4) f... Read More about Physiological and Anthropometrical Indicators of Backpack Running Performance in ??Elite?? British Soldiers: 1384.

High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. (2007)
Journal Article
Simpson, R. J., Florida-James, G., Cosgrove, C., Whyte, G. P., Macrae, S., Pircher, H., & Guy, K. (2007). High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. Journal of Applied Physiology, 103, 396-401. https://doi.org/10.1152/japplphysiol.00007.2007

Clonal expansion of T lymphocytes in response to antigenic stimulation is a fundamental process of adaptive immunity. As a consequence of clonal expansion, some T lymphocytes acquire a senescent phenotype, fail to replicate in response to further ant... Read More about High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects..

Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. (2007)
Journal Article
Middleton, N., Shave, R., George, K., Whyte, G. P., Simpson, R. J., Florida-James, G., & Gaze, D. (2007). Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. Medicine and Science in Sports and Exercise, 39, 83-90. https://doi.org/10.1249/01.mss.0000239395.93578.60

Purpose: The present study examined the impact of repeated bouts of prolonged (< 60 min) exercise on left ventricular function and cardiac biomarkers. Methods: Ten athletes completed a 15.3-mile hill run on three consecutive days and were assessed... Read More about Impact of repeated prolonged exercise bouts on cardiac function and biomarkers..

The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. (2007)
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., Middleton, N., Shave, R., George, K., & Guy, K. (2007). The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. European Journal of Applied Physiology, 99, 201-204. https://doi.org/10.1007/s00421-006-0326-2

Exercise is known to result in the haemolysis of red blood cells (RBCs). Although mechanical stressors such as footstrike and an increased velocity of blood flow may be involved, the biological mechanisms that underpin RBC haemolysis remain elusive.... Read More about The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells..

Physiological variables and performance markers of serving soldiers from two “elite” units of the British Army. (2006)
Journal Article
Simpson, R. J., Gray, S., & Florida-James, G. (2006). Physiological variables and performance markers of serving soldiers from two “elite” units of the British Army. Journal of Sports Sciences, 24, 597-604. https://doi.org/10.1080/02640410500230811

The aim of this study was to compare selected physiological variables and performance markers of soldiers from two “elite” units of the British Army. Ten soldiers from each of the two units were recruited for this study (n = 20). All participants com... Read More about Physiological variables and performance markers of serving soldiers from two “elite” units of the British Army..

Lymphocyte Phenotype Alterations, Pro-Inflammatory Cytokines and Acute Phase Proteins Following Repeated Bouts of Mountainous Hill-Running: 2278 (2006)
Journal Article
Simpson, R. J., Guy, K., Whyte, G. P., Middleton, N., Black, J. R., Ross, J. A., …Florida-James, G. D. (2006). Lymphocyte Phenotype Alterations, Pro-Inflammatory Cytokines and Acute Phase Proteins Following Repeated Bouts of Mountainous Hill-Running: 2278. Medicine and Science in Sports and Exercise, 38(Supplement), S412???S413. https://doi.org/10.1249/00005768-200605001-01739

No abstract available.

The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53. (2006)
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., & Guy, K. (2006). The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53. European Journal of Applied Physiology, 97, 109-121. https://doi.org/10.1007/s00421-006-0146-4

This study examined the effects of intensive, moderate and downhill treadmill running on blood lymphocyte expression of adhesion/activation (AA) molecules. Trained subjects completed three treadmill-running protocols of identical duration: (1) an int... Read More about The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53..

Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM - 11:45 AM (2005)
Journal Article
Simpson, R. J., Guy, K., Whyte, G. P., & Florida-James, G. D. (2005). Lymphocyte Apoptosis, Adhesion/activation Molecules And Complement Regulatory Proteins Following Intensive, Moderate And Eccentric Exercise: 1739 11:30 AM - 11:45 AM. Medicine and Science in Sports and Exercise, 37(Supplement), S336. https://doi.org/10.1097/00005768-200505001-01738

No abstract available.

Immune alterations, lipid peroxidation, and muscle damage following a hill race. (2005)
Journal Article
Simpson, R. J., Wilson, M. R., Black, J., Ross, J. A., Whyte, G. P., Guy, K., & Florida-James, G. (2005). Immune alterations, lipid peroxidation, and muscle damage following a hill race. Canadian Journal of Applied Physiology, 30(2), 196-211. https://doi.org/10.1139/h05-115

Hill races usually include large downhill running sections, which can induce significant degrees of muscle damage in a field setting. This study examined the link between muscle damage, oxidative stress, and immune perturbations following a 7-km moun... Read More about Immune alterations, lipid peroxidation, and muscle damage following a hill race..

Athens 2004: the pollution climate and athletic performance (2004)
Journal Article
Florida-James, G., Donaldson, K., & Stone, V. (2004). Athens 2004: the pollution climate and athletic performance. Journal of Sports Sciences, 22(10), 967-980. https://doi.org/10.1080/02640410400000272

Athens sits in a basin approximately 450 [km.sup.2] in area, surrounded by mountains and open sea. Anthropogenic emissions in conjunction with the topographical and meteorological conditions can result in high air pollution within the city. The pollu... Read More about Athens 2004: the pollution climate and athletic performance.

Effects of Nocturnal Shiftwork on Mood States of Student Nurses (1996)
Journal Article
Florida-james, G., Wallymahmed, A., & Reilly, T. (1996). Effects of Nocturnal Shiftwork on Mood States of Student Nurses. Chronobiology International, 13(1), 59-69. https://doi.org/10.3109/07420529609040842

Daily mood changes were monitored over successive 24-h periods using the Profile of Mood States (POMS) (3) to assess the effect of nocturnal shiftwork on mood. Twenty-three student nurses, age range 19-24 years, were studied throughout their first ex... Read More about Effects of Nocturnal Shiftwork on Mood States of Student Nurses.

The physiological demands of Gaelic football. (1995)
Journal Article
Florida-James, G., & Reilly, T. (1995). The physiological demands of Gaelic football. British Journal of Sports Medicine, 29(1), 41-45. doi:10.1136/bjsm.29.1.41

Match-lay demands of Gaelic football and fitness profiles were assessed at club competitive level. English Gaelic football club championship players (n = 11) were assessed for anthropometry, leg strength and time to exhaustion on a treadmill run. A s... Read More about The physiological demands of Gaelic football..

PINND Survey Report
Report
Campbell, T., Florida-James, G., & Harris, N. PINND Survey Report. Contract Solutions Scotland