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All Outputs (11)

Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers (2016)
Journal Article
Simpson, R. J., Graham, S. M., Connaboy, C., Clement, R., Pollonini, L., & Florida-James, G. D. (2017). Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers. Applied Ergonomics, 58, 566-572. https://doi.org/10.1016/j.apergo.2016.04.010

We developed a standardized laboratory treadmill protocol for assessing physiological responses to a simulated backpack load-carriage task in trained soldiers, and assessed the efficacy of blood lactate thresholds (LTs) and economy in predicting futu... Read More about Blood lactate thresholds and walking/running economy are determinants of backpack-running performance in trained soldiers.

The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression. (2015)
Conference Proceeding
Ross, M. D., Malone, E. M., Simpson, R. J., & Florida-James, G. (2015). The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression

Aging is associated with endothelial dysfunction, reduced angiogenic capabilities, and an increase in arterial stiffness. Additionally, regular exercise is known to offset the age-related decline in blood vessel number and function. Circulating angio... Read More about The influence of age and cardiorespiratory fitness on circulating angiogenic T cells and CXCR4 expression..

The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum (2010)
Journal Article
Florida-James, G. D., McFarlin, B. K., O’Connor, D. P., Simpson, R. J., Booth, S., Florida-James, G., …Simpson, R. J. (2010). The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum. European Journal of Applied Physiology, 110(6), 1259-1268. https://doi.org/10.1007/s00421-010-1616-2

Acute exercise alters the surface expression of toll-like receptors (TLRs) and HLA.DR on blood monocytes, which could transiently compromise immunity. As serum factors might be responsible, we examined the effects of autologous post-exercise serum ex... Read More about The impact of acute strenuous exercise on TLR2, TLR4 and HLA.DR expression on human blood monocytes induced by autologous serum.

Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise (2007)
Journal Article
Campbell, J. P., Guy, K., Cosgrove, C., Florida-James, G., & Simpson, R. J. (2008). Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain, Behavior, and Immunity, 22(3), 375-380. https://doi.org/10.1016/j.bbi.2007.09.001

Cytotoxic T-lymphocytes co-express the T-cell receptor, CD3 and the MHC I restricted antigen CD8. Although total CD8 expression is often used to identify CD8+ T-cells in blood, errors are associated with this method as some CD3 negative natural kille... Read More about Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise.

Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. (2007)
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., Black, J., Ross, J., & Guy, K. (2007). Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans. Research in Sports Medicine, 15, 157-174. https://doi.org/10.1080/15438620701405339

The lymphocytopenia that occurs during the recovery stage of exercise may be a result of apoptosis through an increased expression of CD95, a loss of the complement regulatory proteins CD55 and CD59, or both. Trained subjects completed intensive, mod... Read More about Apoptosis does not contribute to the blood lymphocytopenia observed after intensive and downhill treadmill running in humans..

High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. (2007)
Journal Article
Simpson, R. J., Florida-James, G., Cosgrove, C., Whyte, G. P., Macrae, S., Pircher, H., & Guy, K. (2007). High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. Journal of Applied Physiology, 103, 396-401. https://doi.org/10.1152/japplphysiol.00007.2007

Clonal expansion of T lymphocytes in response to antigenic stimulation is a fundamental process of adaptive immunity. As a consequence of clonal expansion, some T lymphocytes acquire a senescent phenotype, fail to replicate in response to further ant... Read More about High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects..

Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. (2007)
Journal Article
Middleton, N., Shave, R., George, K., Whyte, G. P., Simpson, R. J., Florida-James, G., & Gaze, D. (2007). Impact of repeated prolonged exercise bouts on cardiac function and biomarkers. Medicine and Science in Sports and Exercise, 39, 83-90. https://doi.org/10.1249/01.mss.0000239395.93578.60

Purpose: The present study examined the impact of repeated bouts of prolonged (< 60 min) exercise on left ventricular function and cardiac biomarkers. Methods: Ten athletes completed a 15.3-mile hill run on three consecutive days and were assessed... Read More about Impact of repeated prolonged exercise bouts on cardiac function and biomarkers..

The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. (2007)
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., Middleton, N., Shave, R., George, K., & Guy, K. (2007). The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells. European Journal of Applied Physiology, 99, 201-204. https://doi.org/10.1007/s00421-006-0326-2

Exercise is known to result in the haemolysis of red blood cells (RBCs). Although mechanical stressors such as footstrike and an increased velocity of blood flow may be involved, the biological mechanisms that underpin RBC haemolysis remain elusive.... Read More about The effects of marathon running on expression of the complement regulatory proteins CD55 (DAF) and CD59 (MACIF) on red blood cells..

Physiological variables and performance markers of serving soldiers from two “elite” units of the British Army. (2006)
Journal Article
Simpson, R. J., Gray, S., & Florida-James, G. (2006). Physiological variables and performance markers of serving soldiers from two “elite” units of the British Army. Journal of Sports Sciences, 24, 597-604. https://doi.org/10.1080/02640410500230811

The aim of this study was to compare selected physiological variables and performance markers of soldiers from two “elite” units of the British Army. Ten soldiers from each of the two units were recruited for this study (n = 20). All participants com... Read More about Physiological variables and performance markers of serving soldiers from two “elite” units of the British Army..

The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53. (2006)
Journal Article
Simpson, R. J., Florida-James, G., Whyte, G. P., & Guy, K. (2006). The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53. European Journal of Applied Physiology, 97, 109-121. https://doi.org/10.1007/s00421-006-0146-4

This study examined the effects of intensive, moderate and downhill treadmill running on blood lymphocyte expression of adhesion/activation (AA) molecules. Trained subjects completed three treadmill-running protocols of identical duration: (1) an int... Read More about The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (β2 integrin) and CD53..

Impact of marathon running on cardiac structure and function in recreational runners (2005)
Journal Article
Whyte, G. P., George, K., Shave, R., Dawsons, E., Stephenson, C., Edwards, B., …Simpson, R. J. (2005). Impact of marathon running on cardiac structure and function in recreational runners. Clinical Science, 108(1), 73-80. https://doi.org/10.1042/CS20040186

The present study examined the relationship between LV (left ventricular) function, markers of cardiac-specific damage and markers of oxidative stress in recreational runners following a marathon. Runners (n=52; 43 male and nine female; age, 35±10 ye... Read More about Impact of marathon running on cardiac structure and function in recreational runners.