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Soybean ferritin expression in saccharomyces cerevisiae modulates iron accumulation and resistance to elevated iron concentrations. (2016)
Journal Article
de Llanos, R., Martínez-Garay, C. A., Fita-Torró, J., Romero, A. M., Martínez-Pastor, M. T., & Puig, S. (2016). Soybean ferritin expression in saccharomyces cerevisiae modulates iron accumulation and resistance to elevated iron concentrations. Applied and Environmental Microbiology, 82(10), 3052-3060. https://doi.org/10.1128/AEM.00305-16

Fungi, including the yeast Saccharomyces cerevisiae, lack ferritin and use vacuoles as iron storage organelles. This work explored how plant ferritin expression influenced baker's yeast iron metabolism. Soybean seed ferritin H1 (SFerH1) and SFerH2 ge... Read More about Soybean ferritin expression in saccharomyces cerevisiae modulates iron accumulation and resistance to elevated iron concentrations..

Responses of saccharomyces cerevisiae strains from different origins to elevated iron concentrations. (2016)
Journal Article
Martínez-Garay, C. A., Romero, A. M., Martínez-Pastor, M. T., de Llanos, R., & Puig, S. (2016). Responses of saccharomyces cerevisiae strains from different origins to elevated iron concentrations. Applied and Environmental Microbiology, 82(6), 1906-1916. https://doi.org/10.1128/AEM.03464-15

Iron is an essential micronutrient for all eukaryotic organisms. However, the low solubility of ferric iron has tremendously increased the prevalence of iron deficiency anemia, especially in women and children, with dramatic consequences. Baker's yea... Read More about Responses of saccharomyces cerevisiae strains from different origins to elevated iron concentrations..

Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency (2014)
Journal Article
Sanvisens, N., Romero, A. M., An, X., Zhang, C., de Llanos, R., Martinez-Pastor, M. T., …Puig, S. (2014). Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency. Molecular and Cellular Biology, 34(17), 3259-3271. https://doi.org/10.1128/mcb.00472-14

Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox-active cofactor in many biological processes, including DNA replication and repair. Eukaryotic ribonucleotide reductases (RNRs) are Fe-dependent enzyme... Read More about Yeast Dun1 Kinase Regulates Ribonucleotide Reductase Inhibitor Sml1 in Response to Iron Deficiency.

Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae (2013)
Journal Article
Martínez-Pastor, M., De Llanos, R., Romero, A., & Puig, S. (2013). Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae. International Journal of Molecular Sciences, 14(8), 15785-15809. https://doi.org/10.3390/ijms140815785

Iron is an essential micronutrient for all eukaryotic organisms because it participates as a redox cofactor in a wide variety of biological processes. Recent studies in Saccharomyces cerevisiae have shown that in response to iron deficiency, an RNA-b... Read More about Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae.

Function and Regulation of Yeast Ribonucleotide Reductase: Cell Cycle, Genotoxic Stress, and Iron Bioavailability (2013)
Journal Article
Puig, S., Sanvisens, N., & Llanos, R. D. (2013). Function and Regulation of Yeast Ribonucleotide Reductase: Cell Cycle, Genotoxic Stress, and Iron Bioavailability. Biomedical Journal, 36(2), https://doi.org/10.4103/2319-4170.110398

All eukaryotic organisms require an adequate, balanced concentration of deoxyribonucleoside triphosphates (dNTPs) in order to assure accurate DNA replication and repair, and to maintain genomic integrity. The rate?limiting step in dNTP synthesis is c... Read More about Function and Regulation of Yeast Ribonucleotide Reductase: Cell Cycle, Genotoxic Stress, and Iron Bioavailability.