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All Outputs (31)

Efficiency as a strategic enabler at Edinburgh Napier University (2022)
Digital Artefact
Ramage, L. (2022). Efficiency as a strategic enabler at Edinburgh Napier University. [Blog]

Lindsay Ramage, Head of Research Governance, Edinburgh Napier University, discusses the success of the introduction of Worktribe to manage the ethical review process for research projects.

Increasing academic engagement with the research repository – the value of an integrated system (2017)
Presentation / Conference
Ramage, L., & Gibson, L. (2017, August). Increasing academic engagement with the research repository – the value of an integrated system. Poster presented at Repository Fringe 2017, University of Edinburgh

In August 2016 Edinburgh Napier rolled out their new end-to-end research management system. This allows academics self-service access to record and manage research information from project creation, costing, and post award management as well as addin... Read More about Increasing academic engagement with the research repository – the value of an integrated system.

Implementation of an end-to-end research management system (2017)
Presentation / Conference
Ramage, L. (2017, June). Implementation of an end-to-end research management system. Poster presented at ARMA annual conference

In the past 12-18 months we, at Edinburgh Napier University, have implemented an end to end research management system. We have been involved on the development of the research outputs and repository and research profiles with Worktribe Ltd in addit... Read More about Implementation of an end-to-end research management system.

BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. (2016)
Journal Article
Oughtred, R., Chatr-aryamontri, A., Breitkreutz, B., Chang, C. S., Rust, J. M., Theesfeld, C. L., …Tyers, M. (2016). BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1. Cold Spring Harbor protocols, 2016(1), pdb.top080754. https://doi.org/10.1101/pdb.top080754

The Biological General Repository for Interaction Datasets (BioGRID) is a freely available public database that provides the biological and biomedical research communities with curated protein and genetic interaction data. Structured experimental evi... Read More about BioGRID: A Resource for Studying Biological Interactions in Yeast: Table 1..

Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions (2016)
Journal Article
Oughtred, R., Chatr-aryamontri, A., Breitkreutz, B., Chang, C. S., Rust, J. M., Theesfeld, C. L., …Tyers, M. (2016). Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions. Cold Spring Harbor protocols, 2016(1), pdb.prot088880. https://doi.org/10.1101/pdb.prot088880

The BioGRID database is an extensive repository of curated genetic and protein interactions for the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and the yeast Candida albicans SC5314, as well as for several oth... Read More about Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions.

The BioGRID interaction database: 2015 update (2014)
Journal Article
Chatr-aryamontri, A., Breitkreutz, B., Oughtred, R., Boucher, L., Heinicke, S., Chen, D., …Tyers, M. (2015). The BioGRID interaction database: 2015 update. Nucleic Acids Research, 43(D1), D470-D478. https://doi.org/10.1093/nar/gku1204

The Biological General Repository for Interaction Datasets (BioGRID: http://thebiogrid.org) is an open access database that houses genetic and protein interactions curated from the primary biomedical literature for all major model organism species an... Read More about The BioGRID interaction database: 2015 update.

Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells (2014)
Journal Article
Lipert, B., Wegrzyn, P., Sell, H., Eckel, J., Winiarski, M., Budzynski, A., …Jura, J. (2014). Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells. BBA - Molecular Cell Research, 1843(4), 780-788. https://doi.org/10.1016/j.bbamcr.2014.01.001

Monocyte chemoattractant protein-induced protein 1 (MCPIP1) encoded by the ZC3H12a gene (also known as Regnase-1) is involved in the regulation of degradation of mRNA of inflammatory modulators and for processing of pre-miRNA. These functions depend... Read More about Monocyte chemoattractant protein-induced protein 1 impairs adipogenesis in 3T3-L1 cells.

The BioGRID interaction database: 2013 update (2012)
Journal Article
Chatr-aryamontri, A., Breitkreutz, B., Heinicke, S., Boucher, L., Winter, A., Stark, C., …Tyers, M. (2013). The BioGRID interaction database: 2013 update. Nucleic Acids Research, 41(D1), D816-D823. https://doi.org/10.1093/nar/gks1158

The Biological General Repository for Interaction Datasets (BioGRID: http//thebiogrid.org) is an open access archive of genetic and protein interactions that are curated from the primary biomedical literature for all major model organism species. As... Read More about The BioGRID interaction database: 2013 update.

Integrins and extracellular matrix in mechanotransduction (2011)
Journal Article
Ramage, L. (2011). Integrins and extracellular matrix in mechanotransduction. Cell Health and Cytoskeleton, 2012(4), 1-9. https://doi.org/10.2147/chc.s21829

Integrins are a family of cell surface receptors which mediate cell–matrix and cell–cell adhesions. Among other functions they provide an important mechanical link between the cells external and intracellular environments while the adhesions that the... Read More about Integrins and extracellular matrix in mechanotransduction.

P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration (2009)
Presentation / Conference
Ramage, L., Hardingham, G., & Salter, D. (2009, June). P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration. Paper presented at 2nd Joint meeting of the Bone Research Society and the British Society for Matrix Biology

NMDA receptors (NMDAR) are expressed by chondrocytes in articular cartilage although their function is yet to be fully understood. NMDAR are ionotropic glutamate receptors which when excessively stimulated in neurones induce cell death and neuron... Read More about P088 Involvement of NMDAR in chondrocyte cell death and matrix degeneration.

Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading (2009)
Journal Article
Ramage, L., Nuki, G., & Salter, D. M. (2009). Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading. Scandinavian Journal of Medicine and Science in Sports, 19(4), 457-469. https://doi.org/10.1111/j.1600-0838.2009.00912.x

Mechanical loading of articular cartilage stimulates the metabolism of resident chondrocytes and induces the synthesis of molecules to maintain the integrity of the cartilage. Mechanical signals modulate biochemical activity and changes in cell behav... Read More about Signalling cascades in mechanotransduction: cell-matrix interactions and mechanical loading.

NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins (2008)
Journal Article
Ramage, L., Hardingham, G., & Salter, D. (2008). NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins. Osteoarthritis and Cartilage, 16(S4), S82. https://doi.org/10.1016/s1063-4584%2808%2960207-1

Purpose: Osteoarthritis (OA) is associated with abnormal loading of articular joints. In normal joints physiological loading maintains structure and function of cartilage and chondrocytes within. This is mediated by a process known as mechanotransduc... Read More about NMDA receptor function in osteoarthritic chondrocytes is dependent on β1 integrins.

NMDA receptor expression and activity in osteoarthritic human articular chondrocytes (2008)
Journal Article
Ramage, L., Martel, M., Hardingham, G. E., & Salter, D. M. (2008). NMDA receptor expression and activity in osteoarthritic human articular chondrocytes. Osteoarthritis and Cartilage, 16(12), 1576-1584. https://doi.org/10.1016/j.joca.2008.04.023

Objective: Classical neuronal signalling molecules such as substance P and glutamate have been identified in cartilage and have roles in regulation of chondrocyte function. This study looks at expression and activity of the ionotropic glutamate NMDA... Read More about NMDA receptor expression and activity in osteoarthritic human articular chondrocytes.

P214 NMDA receptor signalling in human osteoarthritic chondrocytes. (2007)
Journal Article
Ramage, L., Hardingham, G., & Salter, D. (2007). P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Osteoarthritis and Cartilage, 15, B142. https://doi.org/10.1016/s1063-4584%2807%2961569-6

Purpose: Human OA chondrocytes are known to express several subunits of the NMDA receptor (NMDAR), a neuronal signalling molecule. This study analyses downstream activation events and interactions of NMDAR with molecules known to be involved in chond... Read More about P214 NMDA receptor signalling in human osteoarthritic chondrocytes..