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Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions (2024)
Journal Article
Neri, I., MacCallum, J., Di Lorenzo, R., Russo, G., Lynen, F., & Grumetto, L. (2024). Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions. Science of the Total Environment, 917, Article 170461. https://doi.org/10.1016/j.scitotenv.2024.170461

Five parabens (PBs) i.e., Methylparaben (MP), Ethylparaben (EP), Isopropylparaben (iPrP), Isobutylparaben (iBuP), Benzylparaben (BzP), and their parent compound i.e., para–hydroxy Benzoic Acid (pHBA), were studied both in vitro and in silico. Specifi... Read More about Into the toxicity potential of an array of parabens by biomimetic liquid chromatography, cell viability assessments and in silico predictions.

From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring? (2023)
Presentation / Conference
Russo, G. (2023, September). From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?. Presented at 10th IAPC Meeting, Belgrade, Serbia

Biomimetic chromatography encompasses a range of analytical approaches aimed at mimicking the asset of biological membranes including – but not limited to – micellar liquid chromatography (MLC), immobilized artificial membranes (IAM) and immobilize... Read More about From ∆log kw IAM to multidimensional biomimetic chromatography: a journey to shed light on the absorption potential of therapeutics. What will the future bring?.

High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC (2023)
Journal Article
Russo, G., Kajtazi, A., Vallaro, M., Surmont, P., Ermondi, G., Anderson, S., …Lynen, F. (2023). High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC. Journal of Pharmaceutical and Biomedical Analysis, 235, Article 115604. https://doi.org/10.1016/j.jpba.2023.115604

The charge state of a molecule is the single most prominent attribute ruling out its interactions with the surrounding environment. In a previous study, the retention of acids on the new Celeris™ Arginine (ARG) column was found to b... Read More about High-throughput and reliable assessments of the ionization constant of monoprotic organic acids through an arginine based mixed mode HPLC.

Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction (2023)
Journal Article
Kajtazi, A., Russo, G., Wicht, K., Eghbali, H., & Lynen, F. (2023). Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction. Chemosphere, 337, Article 139361. https://doi.org/10.1016/j.chemosphere.2023.139361

Implementing effective environmental management strategies requires a comprehensive understanding of the chemical composition of environmental pollutants, particularly in complex mixtures. Utilizing innovative analytical techniques, such as high-reso... Read More about Facilitating structural elucidation of small environmental solutes in RPLC-HRMS by retention index prediction.

The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption (2023)
Presentation / Conference
Dillon, A., Orzek, D., MacCallum, J., & Russo, G. (2023, June). The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption. Poster presented at HPLC 2023

Nowadays immobilized artificial membranes (IAM) are commonly used for modelling drug transport through biological lipid layers. In most published studies a compound’s lipophilicity measurements are performed in isocratic conditions where a low pe... Read More about The effectiveness of biomimetic chromatography based methods in predictions of human pulmonary drug absorption.

Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors (2022)
Journal Article
Russo, G., Piccolo, M., Neri, I., Ferraro, M. G., Santamaria, R., & Grumetto, L. (2023). Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors. Chemosphere, 313, Article 137569. https://doi.org/10.1016/j.chemosphere.2022.137569

Endocrine disruptors are chemicals widely used worldwide by industries in a variety of applications. Routinely exposure to these chemicals, even if at low doses, can cause damage effects on human health. In the present study, we evaluated toxic effec... Read More about Lipophilicity profiling and cell viability assessment of a selected panel of endocrine disruptors.

Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., …Vitale, M. (2023). Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients. Environmental Pollution, 316, Article 120478. https://doi.org/10.1016/j.envpol.2022.120478

Bisphenol A (BPA) is a widespread thyroid disruptor, but evidence about an association with thyroid cancer is weak. Excess body weight is a risk factor for thyroid cancer and affects activity of endocrine disruptors. Aim of the study was to investiga... Read More about Exposure to Bisphenol A increases malignancy risk of thyroid nodules in overweight/obese patients.

Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers (2022)
Journal Article
Di Lorenzo, R., Neri, I., Russo, G., Laneri, S., & Grumetto, L. (2022). Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers. Cosmetics, 9(5), Article 102. https://doi.org/10.3390/cosmetics9050102

A method was set up and validated to identify and quantify seven parabens in each of the three skin layers, i.e., Stratum Corneum, Epidermis, and Dermis, because, even if only some analogues are legally allowed in Europe, forbidden parabens are also... Read More about Tracking Down of a Selected Panel of Parabens: A Validated Method to Evaluate Their Occurrence in Skin Layers.

Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography (2022)
Journal Article
Neri, I., Laneri, S., Di Lorenzo, R., Dini, I., Russo, G., & Grumetto, L. (2022). Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography. Molecules, 27(13), Article 4263. https://doi.org/10.3390/molecules27134263

Parabens (PBs) are used as preservatives to extend the shelf life of various foodstuffs, and pharmaceutical and cosmetic preparations. In this work, the membrane barrier passage potential of a subset of seven parabens, i.e., methyl-, ethyl-, propyl-... Read More about Parabens Permeation through Biological Membranes: A Comparative Study Using Franz Cell Diffusion System and Biomimetic Liquid Chromatography.

Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy (2022)
Journal Article
Russo, G., Laneri, S., Di Lorenzo, R., Neri, I., Dini, I., Ciampaglia, R., & Grumetto, L. (2022). Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy. Molecules, 27(13), Article 3990. https://doi.org/10.3390/molecules27133990

The concentration levels of thirteen organic pollutants and selected heavy metals were investigated in 40 plastics bottled and tap water samples. Some of the selected contaminants have an ascertained or suspected endocrine disrupting activity, such a... Read More about Monitoring of Pollutants Content in Bottled and Tap Drinking Water in Italy.

Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation (2022)
Presentation / Conference
Lynen, F., Russo, G., & Gallikova, J. (2022, May). Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation. Paper presented at 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium

In this work fused deposition modeling (FDM) based 3D-printing is used for the manufacturing of cartridges for solid phase extraction. The novelty of the approach is that the 3D-printing is used for the simultaneous printing of the porous retentive b... Read More about Fused deposition modeling based 3D-printing of solid phase cartridges: development and implementation.

De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater (2022)
Presentation / Conference
Kajtazi, G., Wicht, K., Russo, G., Eghbali, H., & Lynen, F. (2022, May). De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater. Poster presented at 17th International Symposium on Hyphenated Techniques in Chromatography and Separation Technology, Ghent, Belgium

Micropollutants, such as pharmaceuticals, industrial chemicals, steroid hormones, etc. are defined as anthropogenic chemicals and can be found in water. It is seen as a serious threat, not just to aquatic life but also to humans, which requires the a... Read More about De Novo Structural Elucidation Principle via In Silico Chromatographic Retention Index Prediction for Micropollutants in Wastewater.

Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules (2022)
Journal Article
Marotta, V., Grumetto, L., Neri, I., Russo, G., Tortora, A., Izzo, G., …Vitale, M. (2022). Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules. Endocrine abstracts, 81, Article P394. https://doi.org/10.1530/endoabs.81.p394

Introduction: The plasticizer Bisphenol A (BPA) is an endocrine disruptor with thyroid interfering activity. Obesity is a recognized risk factor for thyroid cancer. A recent study showed that subjects with BMI ≥ 25 are more prone to BPA-related thyro... Read More about Synergism between bisphenol a exposure and overweight/obesity in increasing the malignancy risk in a cohort of patients with thyroid nodules.

cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity? (2021)
Journal Article
Grumetto, L., & Russo, G. (2021). cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?. ADMET and DMPK, 9(4), 267-281. https://doi.org/10.5599/admet.1034

56 compounds, whose log BB values were known from the scientific literature, were considered and their phospholipophilicity values were calculated in silico. These values, along with either experimentally determined or calculated lipophilicity values... Read More about cΔlog kwIAM: can we afford estimation of small molecules’ blood-brain barrier passage based upon in silico phospholipophilicity?.

Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis (2021)
Journal Article
Russo, G., Vallaro, M., Cappelli, L., Anderson, S., Ermondi, G., & Caron, G. (2021). Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis. Journal of Chromatography A, 1651, Article 462316. https://doi.org/10.1016/j.chroma.2021.462316

CelerisTM Arginine (ARG) is a mixed-mode stationary phase recently released on the market. To characterize its analytical behavior, the retention factors of a pool (n=100, of which 36 neutrals, 26 acids and 38 bases) of pharmaceutically relevant comp... Read More about Characterization of the new Celeris (TM) Arginine column: retentive behaviour through a combination of chemometric tools and potential in drug analysis.

Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells (2021)
Journal Article
Russo, G., Iaccarino, G., Piccolo, M., Ferraro, M. G., Vecchione, R., Grumetto, L., …Santamaria, R. (2021). Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells. European Journal of Pharmaceutical Sciences, 162, Article 105825. https://doi.org/10.1016/j.ejps.2021.105825

A new isoform of human manganese superoxide dismutase (SOD) has been recently isolated and obtained in a synthetic recombinant form and termed rMnSOD. As compared to other SODs, this isoform exhibits a dramatically improved cellular uptake and an int... Read More about Prolonged activity of a recombinant manganese superoxide dismutase through a formulation of polymeric multi-layer nanoassemblies targeting cancer cells.