All Outputs (36)

Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials (2022)
Journal Article
Martin, S., de Haan, L., Miro Estruch, I., Eder, K. M., Marzi, A., Schnekenburger, J., …Bouwmeester, H. (2022). Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials. Frontiers in Toxicology, 4, Article 974429. https://doi.org/10.3389/ftox.2022.974429

Engineered nanomaterials have been found to induce oxidative stress. Cellular oxidative stress, in turn, can result in the induction of antioxidant and detoxification enzymes which are controlled by the nuclear erythroid 2-related factor 2 (NRF2) tra... Read More about Pre-validation of a reporter gene assay for oxidative stress for the rapid screening of nanobiomaterials.

Case study 10: Facilitating education leadership: Building and sharing an understanding amongst the programme team (2022)
Book Chapter
Malone, E., & Yorkstone, S. (2022). Case study 10: Facilitating education leadership: Building and sharing an understanding amongst the programme team. In J. Lawrence, S. Morón-García, & R. Senior (Eds.), Supporting Course and Programme Leaders in Higher Education: Practical Wisdom for Leaders, Educational Developers and Programme Leaders (191-194). Routledge. https://doi.org/10.4324/9781003127413-37

This case study describes the process of building a programme roadmap to enable a shared understanding and sense of ownership with the various tasks involved in the management of a suite of undergraduate programmes. Collaboration with the institution... Read More about Case study 10: Facilitating education leadership: Building and sharing an understanding amongst the programme team.

How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts (2022)
Journal Article
Macdonald, I., Malone, E., & Firth, R. (2022). How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts. Studies in Higher Education, 47(9), 1980-1996. https://doi.org/10.1080/03075079.2021.2020745

In UK HE institutions there is a growing realisation and appreciation for academic disciplines to seek research partners beyond their own subject (QAA. 2018. Enterprise and entrepreneurship education: Guidance for UK higher education providers. Acces... Read More about How can scientists and designers find ways of working together? A case study of playful learning to co-design visual interpretations of immunology concepts.

Enhancing Programme Management to enable Programme Leadership: A Roadmap for Programmes (2021)
Presentation / Conference
Yorkstone, S., & Malone, E. (2021, June). Enhancing Programme Management to enable Programme Leadership: A Roadmap for Programmes. Paper presented at Horizons in STEM Higher Education Conference: Making Connections, Innovating and Sharing Pedagogy, Online

Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration (2021)
Journal Article
Kirkwood, L., Ingram-Sills, L., Taylor, M. D., Malone, E., & Florida-James, G. (2021). Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration. International Journal of Environmental Research and Public Health, 18(9), Article 4603. https://doi.org/10.3390/ijerph18094603

Introduction: Understanding the sport-specific immune response elicited during both training and competition is imperative to maximise athlete health and performance. Despite a growing population of professional enduro mountain bike athletes, little... Read More about Immune Response of Elite Enduro Racers to Laboratory and Racing Environments: The Influence of Training Impulse and Vibration.

Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure (2019)
Journal Article
Kirkwood, L. A., Taylor, M. D., Ingram, L. A., Malone, E., & Florida-James, G. D. (2019). Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure. Journal of Science and Cycling, 8(1), 18-25. https://doi.org/10.28985/1906.jsc.04

Limited information is currently available regarding the hand-arm vibration (HAV) exposure 5 for professional off-road cyclists. Previous reports have suggested that commuting and 6 recreational cyclists are at risk of exceeding exposure limit values... Read More about Elite mountain bike enduro competition: a study of rider hand-arm vibration exposure.

Rethinking marking: Can applying business improvement techniques help ease the burden of marking on a large project module? (2019)
Presentation / Conference
Malone, E. (2019, February). Rethinking marking: Can applying business improvement techniques help ease the burden of marking on a large project module?. Presented at Supporting Programme Leaders to create cultures of enhancement

Building Ambitious Programme Communities: Generating the impetus for co-creation in Staff Student Liaison Committees (2019)
Presentation / Conference
Malone, E. (2019, January). Building Ambitious Programme Communities: Generating the impetus for co-creation in Staff Student Liaison Committees. Presented at Supporting Programme Leaders to Navigate (and Shape) the Data Landscape

QAA Evidence for Enhancement, Enhancing Programme Leadership event ‘Supporting Programme Leaders to Navigate (and Shape) the Data Landscape’ hosted by Heriot Watt in January 2019.

Flipped Practicals: Present the Problem and Remove the ‘Safety Net’ (2019)
Presentation / Conference
Malone, E. (2019, January). Flipped Practicals: Present the Problem and Remove the ‘Safety Net’. Presented at The Heads of University Biosciences and Royal Society of Biology: New to Teaching Biosciences in Higher Education

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men (2018)
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018). Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), Article e13697. https://doi.org/10.14814/phy2.13697

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T-cells (angiogenic T-cells; TANG) possess highly angiogenic capa... Read More about Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

The gut microbiome rapidly alters the abundance of key bacteria in response to a bout of acute strenuous exercise (2018)
Presentation / Conference
Findlay, S., Ingram, L., Kirkwood, L., Kaczmarek, M., Singleton, I., Malone, E., & Florida-James, G. (2018, April). The gut microbiome rapidly alters the abundance of key bacteria in response to a bout of acute strenuous exercise. Poster presented at BASES Student Conference, Northumbria University, Newcastle upon Tyne

Immunological responses to an international mountain bike enduro race (2018)
Presentation / Conference
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2018, April). Immunological responses to an international mountain bike enduro race. Poster presented at UK Exercise Immunology Specialist Interest Group Symposium, Loughborough, UK

Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2018, April). Immunological responses to an international mountain bike enduro race. Poster presented at UK Exercise Immunology Specialist Interest Group Symposium, Loughborou... Read More about Immunological responses to an international mountain bike enduro race.

Physiological characteristics and performance in elite enduro mountain biking (2017)
Journal Article
Kirkwood, L., Ingram, L., Cunningham, J., Malone, E., & Florida-James, G. (2017). Physiological characteristics and performance in elite enduro mountain biking. Journal of Science and Cycling, 6(2), 13-21. https://doi.org/10.28985/171231.jsc.09

Enduro mountain bike racing is composed of several timed predominantly downhill race stages linked by time restricted, non-competitive transition stages. This study aimed to 1) detail and compare the laboratory assessed physiological characteristics... Read More about Physiological characteristics and performance in elite enduro mountain biking.

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Increase student ownership to build innovation and enterprise in the applied sciences classroom (2017)
Presentation / Conference
Malone, E., & Wright, G. (2017, February). Increase student ownership to build innovation and enterprise in the applied sciences classroom. Presented at The Teaching Fellows Conference, Edinburgh Napier University, Edinburgh

In response to the University’s 2020 Strategy: Building Success and particularly the objective, “to provide a learning environment that develops graduates who have enterprising and innovative mind-sets and who are well prepared to thrive in complex u... Read More about Increase student ownership to build innovation and enterprise in the applied sciences classroom.

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes (2016)
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956

Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is pr... Read More about Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.

Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. (2016)
Presentation / Conference
Malone, E., Ross, B., Rae, M., Bouwmeester, H., Gosens, I., Cassee, F., …Hutchison, G. (2016, September). Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system. Poster presented at 11th International Particle Toxicology Conference

The introduction of engineered nanomaterials (ENM) to new materials and products requires informed risk assessment. The altered physico-chemical properties of ENM mean traditional assays to evaluate toxicity must be modified or validated to ensure... Read More about Development of in vitro strategies to predict in vivo toxicity of engineered nanoparticles to the male reproductive system..

A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells (2016)
Journal Article
Ross, M., Tormey, P., Ingram, L., Simpson, R., Malone, E., & Florida-James, G. (2016). A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells. Experimental Physiology, 101(10), 1253-1264. https://doi.org/10.1113/ep085771

New Findings What is the central question of the study? Are CD31+ angiogenic T (TANG) cells preferentially mobilized in response to acute exercise? What is the main finding and its importance? Our study reveals that TANG cells are redistributed i... Read More about A 10 km time trial running bout acutely increases the number of angiogenic T cells in the peripheral blood compartment of healthy males: Acute exercise mobilizes angiogenic T cells.

Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections (2016)
Presentation / Conference
Oluwadare, E., Rehan, A., Ding, Y., Turnbull, A., Malone, E., Mincher, D., & Proudfoot, L. (2016, September). Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections. Poster presented at Molecular & Cellular Biology of Helminth Parasites X, Hydra, Greece

Anthelmintic resistance and the shortage of new drugs represent an urgent need for the development of novel anti-parasite drugs with effective delivery to the target site. Reduced bioavailability and sub-optimal doses can be responsible for generatio... Read More about Development of mitochondria- and protease-specific prodrugs in the potential treatment of parasitic helminth infections.