All Outputs (3)

Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart (2015)
Journal Article
Wilson, K. S., Baily, J., Tucker, C. S., Matrone, G., Vass, S., Moran, C., Chapman, K. E., Mullins, J. J., Kenyon, C., Hadoke, P. W. F., & Denvir, M. A. (2015). Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart. Molecular and Cellular Endocrinology, 414, 120-131. https://doi.org/10.1016/j.mce.2015.07.025

Background

Transient early-life perturbations in glucocorticoids (GC) are linked with cardiovascular disease risk in later life. Here the impact of early life manipulations of GC on adult heart structure, function and gene expression were assessed... Read More about Early-life perturbations in glucocorticoid activity impacts on the structure, function and molecular composition of the adult zebrafish (Danio rerio) heart.

Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart (2015)
Presentation / Conference Contribution
Wilson, K., Baily, J., Tucker, C., Vass, S., Moran, C., Chapman, K., Mullins, J., Kenyon, C., Hadoke, P., & Denvir, M. Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart

Introduction Foetal over-exposure to glucocorticoids (GC) has been associated with cardiovascular disorder in later life however the impact of transient early life alterations in GC activity on the heart itself has not been widely studied. We explore... Read More about Impact of Glucocorticoid Induced Reprogramming on Functional, Histological and Molecular Signalling in the Adult Zebrafish Heart.

Invadolysin acts genetically via the SAGA complex to modulate chromosome structure (2015)
Journal Article
Janiszewski, M. M., Heck, M. M., Rao, S. G., Janiszewski, M. M., Duca, E., Nelson, B., Abhinav, K., Panagakou, I., Vass, S., & Heck, M. M. S. (2015). Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Research, 43(7), 3546-3562. https://doi.org/10.1093/nar/gkv211

Identification of components essential to chromosome structure and behaviour remains a vibrant area of study. We have previously shown that invadolysin is essential in Drosophila, with roles in cell division and cell migration. Mitotic chromosomes ar... Read More about Invadolysin acts genetically via the SAGA complex to modulate chromosome structure.