All Outputs (6)

Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components (2015)
Journal Article
Boyles, M. S. P., Kristl, T., Andosch, A., Zimmermann, M., Tran, N., Casals, E., Himly, M., Puntes, V., Huber, C. G., Lütz-Meindl, U., & Duschl, A. (2015). Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components. Journal of Nanobiotechnology, 13, Article 84. https://doi.org/10.1186/s12951-015-0146-9

Background
Gold nanoparticles (AuNPs) are a popular choice for use in medical and biomedical research applications. With suitable functionalisation AuNPs can be applied in drug delivery systems, or can aid in disease diagnosis. One such functionalis... Read More about Chitosan functionalisation of gold nanoparticles encourages particle uptake and induces cytotoxicity and pro-inflammatory conditions in phagocytic cells, as well as enhancing particle interactions with serum components.

Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions (2015)
Journal Article
Stoehr, L. C., Endes, C., Radauer-Preiml, I., Boyles, M. S. P., Casals, E., Balog, S., Pesch, M., Petri-Fink, A., Rothen-Rutishauser, B., Himly, M., Clift, M. J. D., & Duschl, A. (2015). Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions. Particle and fibre toxicology, 12, Article 29. https://doi.org/10.1186/s12989-015-0104-6

Background
Stably transfected lung epithelial reporter cell lines pose an advantageous alternative to replace complex experimental techniques to monitor the pro-inflammatory response following nanoparticle (NP) exposure. Previously, reporter cell li... Read More about Assessment of a panel of interleukin-8 reporter lung epithelial cell lines to monitor the pro-inflammatory response following zinc oxide nanoparticle exposure under different cell culture conditions.

Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells (2015)
Journal Article
Stoehr, L. C., Madl, P., Boyles, M. S. P., Zauner, R., Wimmer, M., Wiegand, H., Andosch, A., Kasper, G., Pesch, M., Lütz-Meindl, U., Himly, M., & Duschl, A. (2015). Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells. Environmental Science and Technology, 49(14), 8721-8730. https://doi.org/10.1021/acs.est.5b02503

Air pollution is associated with increased risk of cardiovascular and pulmonary diseases, but conventional air quality monitoring gives no information about biological consequences. Exposing human lung cells at the air–liquid interface (ALI) to ambie... Read More about Enhanced Deposition by Electrostatic Field-Assistance Aggravating Diesel Exhaust Aerosol Toxicity for Human Lung Cells.

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos (2015)
Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., Smail, F., Smith, P. J., Proudfoot, L., Windle, A. H., & Stone, V. (2015). Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012

The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods for CNT production, handling and disposal. In this study aspects reported to... Read More about Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos.

Workflows for automated downstream data analysis and visualization in large‐scale computational mass spectrometry (2015)
Journal Article
Aiche, S., Sachsenberg, T., Kenar, E., Walzer, M., Wiswedel, B., Kristl, T., Boyles, M., Duschl, A., Huber, C. G., Berthold, M. R., Reinert, K., & Kohlbacher, O. (2015). Workflows for automated downstream data analysis and visualization in large‐scale computational mass spectrometry. Proteomics, 15(8), 1443-1447. https://doi.org/10.1002/pmic.201400391

MS-based proteomics and metabolomics are rapidly evolving research fields driven by the development of novel instruments, experimental approaches, and analysis methods. Monolithic analysis tools perform well on single tasks but lack the flexibility t... Read More about Workflows for automated downstream data analysis and visualization in large‐scale computational mass spectrometry.

The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types (2015)
Journal Article
Schlinkert, P., Casals, E., Boyles, M., Tischler, U., Hornig, E., Tran, N., Zhao, J., Riediker, M., Himly, M., Oostingh, G. J., Puntes, V., & Duschl, A. (2015). The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types. Journal of Nanobiotechnology, 13, Article 1. https://doi.org/10.1186/s12951-014-0062-4

Background
Nanoparticle (NPs) functionalization has been shown to affect their cellular toxicity. To study this, differently functionalized silver (Ag) and gold (Au) NPs were synthesised, characterised and tested using lung epithelial cell systems.... Read More about The oxidative potential of differently charged silver and gold nanoparticles on three human lung epithelial cell types.