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Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos (2015)
Journal Article
Boyles, M. S., Young, L., Brown, D. M., MacCalman, L., Cowie, H., Moisala, A., …Stone, V. (2015). Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos. Toxicology in Vitro, 29(7), 1513-1528. https://doi.org/10.1016/j.tiv.2015.06.012

The potential toxicity of carbon nanotubes (CNTs) has been compared to pathogenic fibres such as asbestos. It is important to test this hypothesis to ascertain safe methods for CNT production, handling and disposal. In this study aspects reported to... Read More about Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos.

Investigating performance and lung function in a hot, humid and ozone-polluted environment (2010)
Journal Article
Gomes, E. C., Stone, V., & Florida-James, G. (2010). Investigating performance and lung function in a hot, humid and ozone-polluted environment. European Journal of Applied Physiology, 110(1), 199-205. https://doi.org/10.1007/s00421-010-1485-8

Large urbanized areas, where sports events take place, have a polluted environment and can also reach high temperatures and humidity levels. The aim of this study was to investigate the impact of a hot, humid and ozone-polluted (O3) environment on (1... Read More about Investigating performance and lung function in a hot, humid and ozone-polluted environment.

Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy (2007)
Journal Article
Zhang, F., Hong, S., Stone, V., & Smith, P. (2007). Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy. Journal of Pharmacology and Experimental Therapeutics, 323, 508-515. https://doi.org/10.1124/jpet.107.128272

A clearer understanding of the mechanisms underlying the development and progression of diabetic neuropathy is likely to indicate new directions for the treatment of this complication of diabetes. In the present study we investigated the expression o... Read More about Expression of Cannabinoid CB1 receptors in models of diabetic neuropathy.

An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis. (2007)
Journal Article
Brown, D. M., Kinloch, I. A., Bangert, U., Windle, A., Walter, D. M., Walker, G. S., …Stone, V. (2007). An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis. Carbon, 45, 1743-1756. https://doi.org/10.1016/j.carbon.2007.05.011

There has been little information to date based on the potential health effects and hazards associated with the inhalation of carbon nanofibrous materials by workers despite their growing use in industry. This study examines the in vitro effects of a... Read More about An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis..

Interactions between ultrafine particles and transition metals in vivo and in vitro. (2002)
Journal Article
Wilson, M. R., Lightbody, J., Donaldson, K., Sales, J., & Stone, V. (2002). Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicology and Applied Pharmacology, 184(3), 172-179. https://doi.org/10.1006/taap.2002.9501

Both the ultrafine particle and transition metal components of particulate air pollution (PM10) have been hypothesized to be important factors in determining toxicity and potential adverse health effects. In this study we aimed to investigate interac... Read More about Interactions between ultrafine particles and transition metals in vivo and in vitro..

Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation (2001)
Journal Article
Duffin, R., Gilmour, P. S., Schins, R. P., Clouter, A., Guy, K., Brown, D. M., …Stone, V. (2001). Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation. Toxicology and Applied Pharmacology, 176(1), 10-17. https://doi.org/10.1006/taap.2001.9268

In 1997, an IARC Working Group classified quartz (crystalline silica) as a Group 1 lung carcinogen, but only in some industries, i.e., the quartz hazard is a variable entity. The reactivity of the quartz surface may underlie its ability to cause infl... Read More about Aluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation.

Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. (2001)
Journal Article
Brown, D. M., Wilson, M. R., MacNee, W., Stone, V., & Donaldson, K. (2001). Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicology and Applied Pharmacology, 175(3), 191-199. https://doi.org/10.1006/taap.2001.9240

Studies into the effects of ultrafine particles in the lung have shown adverse effects considered to be due in part to the particle size. Air pollution particles (PM10) are associated with exacerbations of respiratory disease and deaths from cardiova... Read More about Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines..