All Outputs (44)

Cardiovascular Prevention and Rehabilitation for Ischaemic Non‐Obstructive Coronary Artery Disease: Implementation Considerations From a Survey of UK Health Professionals (2025)
Journal Article
Nichols, S., Dawkes, S., Cowie, A., Brown, S., Berry, C., & Humphreys, H. (online). Cardiovascular Prevention and Rehabilitation for Ischaemic Non‐Obstructive Coronary Artery Disease: Implementation Considerations From a Survey of UK Health Professionals. Journal of Advanced Nursing, https://doi.org/10.1111/jan.70023

Aims: Investigate if UK healthcare professionals have the resources and knowledge to provide cardiovascular prevention and rehabilitation to people with ischaemic non‐obstructive coronary artery disease (INOCA), and explore what type of care healthca... Read More about Cardiovascular Prevention and Rehabilitation for Ischaemic Non‐Obstructive Coronary Artery Disease: Implementation Considerations From a Survey of UK Health Professionals.

Practitioner Guidance for Implementing Low-Volume High Intensity Interval Training in People with Coronary Artery Disease (2025)
Journal Article
Ingle, L., Begg, B., Powell, R., Nichols, S., Birkett, S., Young, S., Cowie, A., & McGregor, G. (2025). Practitioner Guidance for Implementing Low-Volume High Intensity Interval Training in People with Coronary Artery Disease. Physiotherapy, 128, Article 101777. https://doi.org/10.1016/j.physio.2025.101777

Objective
High intensity interval training (HIIT) is recognised within many international cardiac rehabilitation (CR) guidelines. In the United Kingdom (UK), however, similar guidance does not exist; moderate intensity training regimens have traditi... Read More about Practitioner Guidance for Implementing Low-Volume High Intensity Interval Training in People with Coronary Artery Disease.

Exploring patients’ views regarding the support and rehabilitation needs of people living with myocardial ischaemia and no obstructive coronary arteries: a qualitative interview study (2024)
Journal Article
Humphreys, H., Paddock, D., Brown, S., Cowie, A., Berry, C., Dawkes, S., & Nichols, S. (2024). Exploring patients’ views regarding the support and rehabilitation needs of people living with myocardial ischaemia and no obstructive coronary arteries: a qualitative interview study. BMJ Open, 14(12), Article e086770. https://doi.org/10.1136/bmjopen-2024-086770

Objectives: This study aimed to generate new qualitative insights to understand the rehabilitation needs of people living with a confirmed or presumed diagnosis of ischaemia with no obstructive coronary arteries (INOCA), explore which aspects of curr... Read More about Exploring patients’ views regarding the support and rehabilitation needs of people living with myocardial ischaemia and no obstructive coronary arteries: a qualitative interview study.

Cost-effectiveness of High-Intensity Interval Training (HIIT) vs Moderate Intensity Steady-State (MISS) Training in UK Cardiac Rehabilitation (2024)
Journal Article
Albustami, M., Hartfiel, N., Charles, J. M., Powell, R., Begg, B., Birkett, S. T., Nichols, S., Ennis, S., Hee, S. W., Banerjee, P., Ingle, L., Shave, R., Mcgregor, G., & Edwards, R. T. (2024). Cost-effectiveness of High-Intensity Interval Training (HIIT) vs Moderate Intensity Steady-State (MISS) Training in UK Cardiac Rehabilitation. Archives of Physical Medicine and Rehabilitation, 105(4), 639-646. https://doi.org/10.1016/j.apmr.2023.09.005

Objective: To perform a cost-effectiveness analysis of high-intensity interval training (HIIT) compared with moderate intensity steady-state (MISS) training in people with coronary artery disease (CAD) attending cardiac rehabilitation (CR). Design: S... Read More about Cost-effectiveness of High-Intensity Interval Training (HIIT) vs Moderate Intensity Steady-State (MISS) Training in UK Cardiac Rehabilitation.

Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial (2024)
Journal Article
Ingle, L., Powell, R., Begg, B., Birkett, S. T., Nichols, S., Ennis, S., Banerjee, P., Shave, R., & McGregor, G. (2024). Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial. Archives of Physical Medicine and Rehabilitation, 105(8), 1464-1470. https://doi.org/10.1016/j.apmr.2024.03.002

The objective of this study was to compare the characteristics of responders and nonresponders to 8 weeks of exercise training, to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD). This was und... Read More about Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial.

Inter- and intra-observer reliability and agreement of O2Pulse inflection during cardiopulmonary exercise testing: A comparison of subjective and novel objective methodology (2024)
Journal Article
Nickolay, T., McGregor, G., Powell, R., Begg, B., Birkett, S., Nichols, S., Ennis, S., Banerjee, P., Shave, R., Metcalfe, J., Hoye, A., & Ingle, L. (2024). Inter- and intra-observer reliability and agreement of O2Pulse inflection during cardiopulmonary exercise testing: A comparison of subjective and novel objective methodology. PLOS ONE, 19(3), Article e0299486. https://doi.org/10.1371/journal.pone.0299486

Cardiopulmonary exercise testing (CPET) is the ‘gold standard’ method for evaluating functional capacity, with oxygen pulse (O2Pulse) inflections serving as a potential indicator of myocardial ischaemia. However, the reliability and agreement of iden... Read More about Inter- and intra-observer reliability and agreement of O2Pulse inflection during cardiopulmonary exercise testing: A comparison of subjective and novel objective methodology.

Standards for Physical Activity and Exercise in Cardiovascular Populations (2023)
Other
Probert, H., Cowie, A., Young, S., Brownlie, F., Grove, T., Kelliher, N., & Nichols, S. (2023). Standards for Physical Activity and Exercise in Cardiovascular Populations

Provision of dietary education in UK-based cardiac rehabilitation: a cross-sectional survey conducted in conjunction with the British Association for Cardiovascular Prevention and Rehabilitation (2023)
Journal Article
James, E., Butler, T., Nichols, S., Goodall, S., & O'Doherty, A. F. (2024). Provision of dietary education in UK-based cardiac rehabilitation: a cross-sectional survey conducted in conjunction with the British Association for Cardiovascular Prevention and Rehabilitation. British Journal of Nutrition, 131(5), 880-893. https://doi.org/10.1017/s0007114523002374

Dietary education is a core component of cardiac rehabilitation (CR). It is unknown how or what dietary education is delivered across the UK. We aimed to characterise practitioners who deliver dietary education in UK CR and determine the format and c... Read More about Provision of dietary education in UK-based cardiac rehabilitation: a cross-sectional survey conducted in conjunction with the British Association for Cardiovascular Prevention and Rehabilitation.

Remote ischaemic conditioning for fatigue after stroke (RICFAST): A pilot randomised controlled trial (2023)
Journal Article
Moyle, B., Kudiersky, N., Totton, N., Sassani, M., Nichols, S., Jenkins, T., Redgrave, J., Baig, S., Padmakumari, K., Nair, S., Majid, A., & Ali, A. N. (2023). Remote ischaemic conditioning for fatigue after stroke (RICFAST): A pilot randomised controlled trial. Journal of Stroke and Cerebrovascular Diseases, 32(12), Article 107420. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107420

Background: Post stroke fatigue (PSF) affects 50 % of stroke survivors, and can be disabling. Remote ischaemic conditioning (RIC), can preserve mitochondrial function, improve tissue perfusion and may mitigate PSF. This pilot randomised controlled tr... Read More about Remote ischaemic conditioning for fatigue after stroke (RICFAST): A pilot randomised controlled trial.

A randomised controlled, feasibility study to establish the acceptability of early outpatient review and early cardiac rehabilitation compared to standard practice after cardiac surgery and viability of a future large-scale trial (FARSTER) (2023)
Journal Article
Ngaage, D. L., Mitchell, N., Dean, A., Mitchell, A., Hinde, S., Akowuah, E., Doherty, P., Nichols, S., Fairhurst, C., Flemming, K., Hewitt, C., Ingle, L., & Watson, J. (2023). A randomised controlled, feasibility study to establish the acceptability of early outpatient review and early cardiac rehabilitation compared to standard practice after cardiac surgery and viability of a future large-scale trial (FARSTER). Pilot and Feasibility Studies, 9(1), Article 79. https://doi.org/10.1186/s40814-023-01304-3

Objective
To determine the acceptability and feasibility of delivering early outpatient review following cardiac surgery and early cardiac rehabilitation (CR), compared to standard practice to establish if a future large-scale trial is achievable.... Read More about A randomised controlled, feasibility study to establish the acceptability of early outpatient review and early cardiac rehabilitation compared to standard practice after cardiac surgery and viability of a future large-scale trial (FARSTER).

Research priorities relating to the delivery of cardiovascular prevention and rehabilitation programmes: results of a modified Delphi process (2023)
Journal Article
McHale, S., Cowie, A., Brown, S., Butler, T., Carver, K., Dalal, H. M., Dawkes, S., Deighan, C., Doherty, P., Evans, J., Hinton, S., Jones, J., Mills, J., Nichols, S., & Taylor, R. S. (2023). Research priorities relating to the delivery of cardiovascular prevention and rehabilitation programmes: results of a modified Delphi process. Open Heart, 10(1), Article e002248. https://doi.org/10.1136/openhrt-2022-002248

Objective: The purpose of this British Association for Cardiovascular Prevention and Rehabilitation (BACPR) research priority setting project (PSP) was to identify a top 10 list of priority research questions for cardiovascular prevention and rehabil... Read More about Research priorities relating to the delivery of cardiovascular prevention and rehabilitation programmes: results of a modified Delphi process.

Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study (2023)
Journal Article
James, E., Goodall, S., Nichols, S., Walker, K., Carroll, S., O'Doherty, A. F., & Ingle, L. (2023). Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study. Frontiers in Medicine, 10, Article 1094733. https://doi.org/10.3389/fmed.2023.1094733

Background: Low muscle mass disproportionately affects people with coronary heart disease compared to healthy controls but is under-researched and insufficiently treated. Inflammation, poor nutrition, and neural decline might contribute to low muscle... Read More about Serum transthyretin and aminotransferases are associated with lean mass in people with coronary heart disease: Further insights from the CARE-CR study.

High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial (2023)
Journal Article
McGregor, G., Powell, R., Begg, B., Birkett, S. T., Nichols, S., Ennis, S., McGuire, S., Prosser, J., Fiassam, O., Hee, S. W., Hamborg, T., Banerjee, P., Hartfiel, N., Charles, J. M., Edwards, R. T., Drane, A., Ali, D., Osman, F., He, H., Lachlan, T., …Shave, R. (2023). High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial. European Journal of Preventive Cardiology, 30(9), 745-755. https://doi.org/10.1093/eurjpc/zwad039

Background
There is a lack of international consensus regarding the prescription of high-intensity interval training (HIIT) for people with coronary artery disease (CAD) attending cardiac rehabilitation (CR).

Aims
To assess the clinical effectiv... Read More about High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial.

The effectiveness of a targeted protein education intervention to increase protein intake in patients with coronary heart disease and low protein intake: A pilot randomised controlled trial (2022)
Presentation / Conference Contribution
James, E., Das, R., Rickleton, E., Cummins, S., Nichols, S., Goodall, S., & O’Doherty, A. F. (2022, October). The effectiveness of a targeted protein education intervention to increase protein intake in patients with coronary heart disease and low protein intake: A pilot randomised controlled trial. Presented at BACPR Annual Conference abstracts, Birmingham Conference and Events Centre

Background
Low protein intake is prevalent in, and detrimental to, patients with coronary heart disease (CHD). We have shown that protein education in UK cardiac rehabilitation (CR) needs improvement. Evidence-based targeted protein education may i... Read More about The effectiveness of a targeted protein education intervention to increase protein intake in patients with coronary heart disease and low protein intake: A pilot randomised controlled trial.

Provision of dietary education in UK-based cardiac rehabilitation: a cross-sectional survey (2022)
Presentation / Conference Contribution
O’Doherty, A. F., James, E., Nichols, S., Goodall, S., & Butler, T. (2022, October). Provision of dietary education in UK-based cardiac rehabilitation: a cross-sectional survey. Presented at BACPR Annual Conference abstracts, Birmingham

Background
The cardioprotective diet is effective in reducing risk of mortality and morbidity in patients with heart disease. Therefore, high-quality dietary education in UK cardiac rehabilitation (CR) is needed. However, little is known about it... Read More about Provision of dietary education in UK-based cardiac rehabilitation: a cross-sectional survey.

Exploring the validity of VentriJect Seismofit® for estimating peak oxygen uptake in people with coronary heart disease (2022)
Presentation / Conference Contribution
Myers, A., Ali, A., Kudiersky, N., Søgaard, P., Schmidt, S., Girard, W., O’Doherty, A., & Nichols, S. (2022, October). Exploring the validity of VentriJect Seismofit® for estimating peak oxygen uptake in people with coronary heart disease. Presented at BACPR Annual Conference, Birmingham, UK

Background
Peak oxygen uptake ( _ VO2peak) predicts all-cause mortality and can indicate the effectiveness of exercise-based cardiovascular rehabilitation (CR) in people living with coronary heart disease (CHD). Maximal cardiopulmonary exercise test... Read More about Exploring the validity of VentriJect Seismofit® for estimating peak oxygen uptake in people with coronary heart disease.

The effectiveness of the Healthworks Staying Steady community-based falls prevention exercise programme to improve physical function in older adults: a 6-year service evaluation (2022)
Journal Article
James, E., Oman, P., Ali, M., Court, P., Goodall, S., Nichols, S. J., & O'doherty, A. F. (2022). The effectiveness of the Healthworks Staying Steady community-based falls prevention exercise programme to improve physical function in older adults: a 6-year service evaluation. BMC Public Health, 22(1), Article 1457. https://doi.org/10.1186/s12889-022-13832-3

Background: Falls prevention exercise programmes are evidence-based and recommended for improving physical function in older adults. However, few service evaluations exist to assess the effectiveness of community-delivered interventions in practice.... Read More about The effectiveness of the Healthworks Staying Steady community-based falls prevention exercise programme to improve physical function in older adults: a 6-year service evaluation.

Changes in patient activation following cardiac rehabilitation using the Active+me digital healthcare platform during the COVID-19 pandemic: a cohort evaluation (2021)
Journal Article
Frith, G., Carver, K., Curry, S., Darby, A., Sydes, A., Symonds, S., Wilson, K., Mcgregor, G., Auton, K., & Nichols, S. (2021). Changes in patient activation following cardiac rehabilitation using the Active+me digital healthcare platform during the COVID-19 pandemic: a cohort evaluation. BMC Health Services Research, 21(1), Article 1363. https://doi.org/10.1186/s12913-021-07363-7

Background: Restrictions on face-to-face contact, due to COVID-19, led to a rapid adoption of technology to remotely deliver cardiac rehabilitation (CR). Some technologies, including Active + me, were used without knowing their benefits. We assessed... Read More about Changes in patient activation following cardiac rehabilitation using the Active+me digital healthcare platform during the COVID-19 pandemic: a cohort evaluation.

Ratings of Perceived Exertion at the Ventilatory Anaerobic Threshold in People with Coronary Heart Disease: A CARE CR study (2021)
Journal Article
Nichols, S., Engin, B., Carroll, S., Buckley, J., & Ingle, L. (2021). Ratings of Perceived Exertion at the Ventilatory Anaerobic Threshold in People with Coronary Heart Disease: A CARE CR study. Annals of Physical and Rehabilitation Medicine, 64(6), Article 101462. https://doi.org/10.1016/j.rehab.2020.101462

Background
Exercise prescription guidelines for individuals undergoing cardiovascular rehabilitation (CR) are often based on heart rate training zones and rating of perceived exertion (RPE). United Kingdom guidelines indicate that patients should ex... Read More about Ratings of Perceived Exertion at the Ventilatory Anaerobic Threshold in People with Coronary Heart Disease: A CARE CR study.

Effect of Exercise Interventions on Health-Related Quality of Life After Stroke and Transient Ischemic Attack: A Systematic Review and Meta-Analysis (2021)
Journal Article
Ali, A., Tabassum, D., Baig, S. S., Moyle, B., Redgrave, J., Nichols, S., McGregor, G., Evans, K., Totton, N., Cooper, C., & Majid, A. (2021). Effect of Exercise Interventions on Health-Related Quality of Life After Stroke and Transient Ischemic Attack: A Systematic Review and Meta-Analysis. Stroke, 52(7), 2445-2455. https://doi.org/10.1161/strokeaha.120.032979

Exercise interventions have been shown to help physical fitness, walking, and balance after stroke, but data are lacking on whether such interventions lead to improvements in health-related quality of life (HRQoL). In this systematic review and meta-... Read More about Effect of Exercise Interventions on Health-Related Quality of Life After Stroke and Transient Ischemic Attack: A Systematic Review and Meta-Analysis.