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All Outputs (9)

Effect of aspirin and NSAIDs on risk and survival from colorectal cancer (2010)
Journal Article
Din, F. V. N., Theodoratou, E., Farrington, S. M., Tenesa, A., Barnetson, R. A., Cetnarskyj, R., …Dunlop, M. G. (2010). Effect of aspirin and NSAIDs on risk and survival from colorectal cancer. Gut, 59, 1670-1679. https://doi.org/10.1136/gut.2009.203000

Background Previous studies have shown that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) lower colorectal cancer (CRC) risk. However, the lowest effective NSAID dose, treatment duration, and effects on survival are not defined. In... Read More about Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.

Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21 (2008)
Journal Article
Tenesa, A., Farrington, S. M., Prendergast, J. G. D., Porteous, M. E., Walker, M., Haq, N., …Dunlop, M. G. (2008). Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40, 631-637. https://doi.org/10.1038/ng.133

In a genome-wide association study to identify loci associated with colorectal cancer (CRC) risk, we genotyped 555,510 SNPs in 1,012 early-onset Scottish CRC cases and 1,012 controls (phase 1). In phase 2, we genotyped the 15,008 highest-ranked SNPs... Read More about Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.

Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants (2008)
Journal Article
Theodoratou, E., Campbell, H., Tenesa, A., McNeill, G., Cetnarskyj, R., Barnetson, R. A., …Farrington, S. M. (2008). Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants. Carcinogenesis, 29, 1774-1780. https://doi.org/10.1093/carcin/bgn082

In a large Scottish case–control study, we investigated the effects of adenomatous polyposis coli (APC) Asp1822Val (rs459552) and APC Glu1317Gln substitutions on colorectal cancer (CRC) risk and whether these associations were influenced by lifestyle... Read More about Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variants.

Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding (2008)
Journal Article
Theodoratou, E., Farrington, S. M., Tenesa, A., McNeill, G., Cetnarskyj, R., Barnetson, R. A., …Campbell, H. (2008). Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding. International Journal of Cancer, 123, 2170-2179. https://doi.org/10.1002/ijc.23769

Vitamin D has anticarcinogenic properties and might influence colorectal cancer (CRC) risk, but the epidemiological evidence is inconsistent. Many mechanisms of action for vitamin D have been proposed, with some of them initiating via its binding to... Read More about Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by aFokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR binding.

Identification and survival of carriers of mutations in DNA mis-match repair genes in colon cancer. (2006)
Journal Article
Barnetson, R. A., Tenesa, A., Farrington, S. M., Nicholl, I. D., Cetnarskyj, R., Porteous, M. E., …Dunlop, M. G. (2006). Identification and survival of carriers of mutations in DNA mis-match repair genes in colon cancer. New England Journal of Medicine. 354. . 2751-2763. . ISSN 0028-4793.

Background The identification of mutations in germ-line DNA mismatch-repair genes at the time of diagnosis of colorectal cancer is important in the management of the disease. Methods Without preselection and regardless of family history, we recru... Read More about Identification and survival of carriers of mutations in DNA mis-match repair genes in colon cancer..

A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a Scottish general practice population (2004)
Journal Article
Wallace, E., Hinds, A., Campbell, H., Mackay, J., Cetnarskyj, R., & Porteous, M. E. M. (2004). A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a Scottish general practice population. British Journal of Cancer, 91, 1575-1579. https://doi.org/10.1038/sj.bjc.6602155

A cross-sectional survey of all patients aged 30-65 in four general practices within one Local Health Care Co-operative in Fife, Scotland was undertaken to measure the prevalence of family history of colorectal, breast and ovarian cancer. A total of... Read More about A cross-sectional survey to estimate the prevalence of family history of colorectal, breast and ovarian cancer in a Scottish general practice population.

Patient satisfaction with two different models of cancer genetic services in south-east Scotland (2004)
Journal Article
Holloway, S., Porteous, M., Cetnarskyj, R., Anderson, E., Rush, R., Fry, A., …Campbell, H. (2004). Patient satisfaction with two different models of cancer genetic services in south-east Scotland. British Journal of Cancer, 90(3), 582-589. https://doi.org/10.1038/sj.bjc.6601562

There is a need to integrate primary- and secondary-care cancer genetic services, but the most appropriate model of service delivery remains unclear. This study reports patients' expectations of breast cancer genetic services and a comparison of thei... Read More about Patient satisfaction with two different models of cancer genetic services in south-east Scotland.

Referrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland (2003)
Journal Article
Campbell, H., Holloway, S., Cetnarskyj, R., Anderson, E., Rush, R., Fry, A., …Porteous, M. (2003). Referrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland. British Journal of Cancer, 89(9), 1650-1656. https://doi.org/10.1038/sj.bjc.6601348

As part of a cluster randomised trial to assess an alternative model of cancer genetics services, we gathered data on all referrals from general practitioners (GPs) to cancer genetics services in South East Scotland over a 4-year period. The referral... Read More about Referrals of women with a family history of breast cancer from primary care to cancer genetics services in South East Scotland.