Skip to main content

Research Repository

Advanced Search

All Outputs (82)

The value of livestock abortion surveillance in Tanzania: identifying disease priorities and informing interventions (2024)
Working Paper
Lankester, F., Kibona, T. J., Allan, K. J., de Glanville, W., Buza, J. J., Katzer, F., …Cleaveland, S. (2024). The value of livestock abortion surveillance in Tanzania: identifying disease priorities and informing interventions

Background: Lack of reliable data on the aetiology of livestock diseases, especially in Africa, is a major factor constraining the design of effective livestock health interventions to improve livelihoods, food security and public health. Rationa... Read More about The value of livestock abortion surveillance in Tanzania: identifying disease priorities and informing interventions.

Q fever and Coxiellosis implications for livestock and human health: a UK perspective (2023)
Journal Article
Wheelhouse, N., Vazquez, R., Viora, L., & Halliday, J. E. (2023). Q fever and Coxiellosis implications for livestock and human health: a UK perspective. Livestock, 28(5), 193-238. https://doi.org/10.12968/live.2023.28.5.221

Q fever is a disease which can cause an acute self-limiting infection or long-term chronic condition in people exposed to the bacteria Coxiella burnetii. Most human cases in the UK are associated with livestock, particularly small ruminants, which ac... Read More about Q fever and Coxiellosis implications for livestock and human health: a UK perspective.

Methane and Health Dialogue Series: April 11, 26 and May 10, 2023 (2023)
Report
(2023). Methane and Health Dialogue Series: April 11, 26 and May 10, 2023. Environmental Defense Fund (EDF)

The climate crisis is also a public health crisis, and methane, due to its impact on warming and air quality, threatens human health. Cutting methane is the quickest, most effective way to address climate change while delivering significant near-term... Read More about Methane and Health Dialogue Series: April 11, 26 and May 10, 2023.

Seroprevalence and risk factors for Q-fever (Coxiella burnetii) exposure in smallholder dairy cattle in Tanzania (2022)
Journal Article
Festo Bwatota, S., Mkilema Shirima, G., Hernandez-Castro, L. E., Mark de Clare Bronsvoort, B., Wheelhouse, N., Joseph Mengele, I., …Cook, E. A. J. (2022). Seroprevalence and risk factors for Q-fever (Coxiella burnetii) exposure in smallholder dairy cattle in Tanzania. Veterinary Sciences, 9(12), Article 662. https://doi.org/10.3390/vetsci9120662

Q fever is a zoonotic disease, resulting from infection with Coxiella burnetii. Infection in cattle can cause abortion and infertility, however, there is little epidemiological information regarding the disease in dairy cattle in Tanzania. Between Ju... Read More about Seroprevalence and risk factors for Q-fever (Coxiella burnetii) exposure in smallholder dairy cattle in Tanzania.

Epidemiology of q-fever in domestic ruminants and humans in Africa: A systematic review (2022)
Journal Article
Festo Bwatota, S., Cook, E. A. J., Mark de Clare Bronsvoort, B., Wheelhouse, N., Hernandez-Castor, L. E., & Mkilema Shirima, G. (2022). Epidemiology of q-fever in domestic ruminants and humans in Africa: A systematic review. CABI One Health, https://doi.org/10.1079/cabionehealth.2022.0008

Q-fever is a zoonotic infectious disease caused by the gram-negative, intracellular, spore-forming bacterium Coxiella burnetii. Infected ruminants (cattle, sheep, and goats) are the reservoirs of the pathogen and thus an important source of infection... Read More about Epidemiology of q-fever in domestic ruminants and humans in Africa: A systematic review.

Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya (2022)
Journal Article
Muema, J., Nyamai, M., Wheelhouse, N., Njuguna, J., Jost, C., Oyugi, J., …Thumbi, S. (2022). Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya. Heliyon, 8(10), Article e11133. https://doi.org/10.1016/j.heliyon.2022.e11133

Background Coxiella burnetti can be transmitted to humans primarily through inhaling contaminated droplets released from infected animals or consumption of contaminated dairy products. Despite its zoonotic nature and the close association pastoralis... Read More about Endemicity of Coxiella burnetii infection among people and their livestock in pastoral communities in northern Kenya.

Modelling the Transmission of Coxiella burnetii within a UK Dairy Herd: Investigating the Interconnected Relationship between the Parturition Cycle and Environment Contamination (2022)
Journal Article
Patsatzis, D. G., Wheelhouse, N., & Tingas, E. (2022). Modelling the Transmission of Coxiella burnetii within a UK Dairy Herd: Investigating the Interconnected Relationship between the Parturition Cycle and Environment Contamination. Veterinary Sciences, 9(10), Article 522. https://doi.org/10.3390/vetsci9100522

Q fever infection in dairy herds is introduced through the transmission of the bacterium Coxiella burnetii, resulting in multiple detrimental effects such as reduction of lactation, abortions and chronic infection. Particularly in the UK, recent evid... Read More about Modelling the Transmission of Coxiella burnetii within a UK Dairy Herd: Investigating the Interconnected Relationship between the Parturition Cycle and Environment Contamination.

Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania (2022)
Journal Article
Thomas, K. M., Kibona, T., Claxton, J. R., de Glanville, W. A., Lankester, F., Amani, N., …Allan, K. J. (2022). Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania. Scientific Reports, 12(1), Article 11669. https://doi.org/10.1038/s41598-022-15517-8

Livestock abortion is an important cause of productivity losses worldwide and many infectious causes of abortion are zoonotic pathogens that impact on human health. Little is known about the relative importance of infectious causes of livestock abort... Read More about Prospective cohort study reveals unexpected aetiologies of livestock abortion in northern Tanzania.

Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease (2022)
Journal Article
Turin, L., Surini, S., Wheelhouse, N., & Rocchi, M. S. (2022). Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease. Veterinary Research, 53(1), Article 37. https://doi.org/10.1186/s13567-022-01052-x

Environmental transmission of Chlamydia abortus as a result of enzootic disease or disease outbreaks and the threats posed by this pathogen has been previously reported, however a state-of-the-science review of these reports and the identification of... Read More about Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease.

Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle (2021)
Journal Article
Wheelhouse, N., Hearn, J., Livingstone, M., Flockhart, A., Dagleish, M., & Longbottom, D. (2022). Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle. Journal of Applied Microbiology, 132(4), 2642-2648. https://doi.org/10.1111/jam.15422

Aims The order Chlamydiales comprises a broad range of bacterial pathogens and endosymbionts, which infect a wide variety of host species. Within this order, members of the family Parachlamydiaceae, which includes Parachlamydia and Neochlamydia spec... Read More about Identification of Parachlamydiaceae DNA in nasal and rectal passages of healthy dairy cattle.

Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion (2021)
Journal Article
Livingstone, M., Ranjan Wattegedera, S., Palarea-Albaladejo, J., Aitchison, K., Corbett, C., Sait, M., …Longbottom, D. (2021). Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion. Vaccines, 9(8), Article 898. https://doi.org/10.3390/vaccines9080898

Chlamydia abortus, the aetiological agent of enzootic abortion of ewes, is a major cause of reproductive loss in small ruminants worldwide, accounting for significant economic losses to the farming industry. Disease can be managed through the use of... Read More about Efficacy of two Chlamydia abortus subcellular vaccines in a pregnant ewe challenge model for ovine enzootic abortion.

Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells (2021)
Journal Article
Brown, M., Rae, M., & Wheelhouse, N. (2021). Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells. Reproduction and Fertility, 2(1), 9-11. https://doi.org/10.1530/RAF-20-0069

Chlamydia trachomatis is the most commonly diagnosed sexually transmitted infection in the UK, with over 200,000 positive diagnoses annually. The infection is thought to cause reproductive complications including problems in conceiving a pregnancy th... Read More about Chlamydia inhibits progesterone receptor mRNA expression in SHT-290 cells.

Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania (2020)
Journal Article
Theonest, N. O., Carter, R. W., Kasagama, E., Keyyu, J. D., Shirima, G. M., Tarimo, R., …Halliday, J. E. (2021). Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania. Veterinary Medicine and Science, 7(3), 960-967. https://doi.org/10.1002/vms3.401

Coxiella burnetii is an obligate intracellular bacterium that causes Q fever, a zoonotic disease of public health importance. In northern Tanzania, Q fever is a known cause of human febrile illness, but little is known about its distribution in anima... Read More about Molecular detection of Coxiella burnetii infection in small mammals from Moshi Rural and Urban Districts, northern Tanzania.

Defining immune correlates during latent and active chlamydial infection in sheep (2020)
Journal Article
Ranjan Wattegedera, S., Livingstone, M., Maley, S., Rocchi, M., Lee, S., Pang, Y., …Entrican, G. (2020). Defining immune correlates during latent and active chlamydial infection in sheep. Veterinary Research, 51, Article 75 (2020). https://doi.org/10.1186/s13567-020-00798-6

Ovine enzootic abortion (OEA) caused by the obligate intracellular bacterial pathogen Chlamydia abortus (C. abortus), is an endemic disease in most sheep-rearing countries worldwide. Following infection, C. abortus establishes a complex host–pathogen... Read More about Defining immune correlates during latent and active chlamydial infection in sheep.

Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning (2019)
Journal Article
Longbottom, D., Livingstone, M., Aitchison, K. D., Imrie, L., Manson, E., Wheelhouse, N., & Inglis, N. F. (2019). Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning. PLOS ONE, 14(10), Article e0224070. https://doi.org/10.1371/journal.pone.0224070

Data are presented on the identification and partial characterisation of proteins comprising the chlamydial outer membrane complex (COMC) fraction of Chlamydia abortus (C. abortus)—the aetiological agent of ovine enzootic abortion. Inoculation with t... Read More about Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning.

Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study (2019)
Journal Article
Brown, S., Paterson, C., Dougall, N., Cameron, S., & Wheelhouse, N. (2019). Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study. BMC Public Health, 19(1), Article 992. https://doi.org/10.1186/s12889-019-7313-0

Background Chlamydia trachomatis (C. trachomatis) is the most common bacterial sexually transmitted infection in the UK. Recent studies suggest that in addition to the genital tract, C. trachomatis is found in the throat and rectum, suggesting the n... Read More about Understanding the attitudes and acceptability of extra-genital Chlamydia testing in young women: evaluation of a feasibility study.

Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential. (2019)
Journal Article
Smith, A., Hearn, J., Taylor, C., Wheelhouse, N., Kaczmarek, M., Moorhouse, E., & Singleton, I. (2019). Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential. International Journal of Food Microbiology, 299, 23-32. https://doi.org/10.1016/j.ijfoodmicro.2019.03.013

Listeria monocytogenes is sporadically detected on a range of ready to eat fresh produce lines, such as spinach and rocket, and is a threat to public health. However, little is known about the diversity of L. monocytogenes present on fresh produce an... Read More about Listeria monocytogenes isolates from ready to eat plant produce are diverse and have virulence potential..