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Statistical parametric mapping of 99mTc-HMPAO-SPECT images for the diagnosis of Alzheimer's disease: normalizing to cerebellar tracer uptake. (2002)
Journal Article
Soonawala, D., Amin, T., Ebmeier, K. P., Steele, J. D., Dougall, N. J., Best, J., …Scheidhauer, K. (2002). Statistical parametric mapping of 99mTc-HMPAO-SPECT images for the diagnosis of Alzheimer's disease: normalizing to cerebellar tracer uptake. NeuroImage. 17. (3). 1193-1202. doi:10.1006/nimg.2002.1259. ISSN 1053-8119.

Background: for a quantitative comparison of images obtained during 99mTc-hexamethylpropylene amine oxime (HMPAO) single-photon emission computed tomography (SPECT), brain activity values are usually normalized to a reference region. In studies of Al... Read More about Statistical parametric mapping of 99mTc-HMPAO-SPECT images for the diagnosis of Alzheimer's disease: normalizing to cerebellar tracer uptake..

A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET (1996)
Journal Article
Prentice, N., Van Beck, M., Dougall, N. J., Moffoot, A. P. R., O'Carroll, R. E., Goodwin, G. M., & Ebmeier, K. P. (1996). A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET. Journal of Psychopharmacology, 10(3), 175-181. https://doi.org/10.1177/026988119601000301

Background: the effect of single-dose and long-term cholinergic enhancement with tacrine on regional cerebral perfusion was examined in patients with Alzheimer's disease using single-photon emission tomography (SPET). Method: 23 patients with probabl... Read More about A double-blind, placebo-controlled study of tacrine in patients with Alzheimer's disease using SPET.

The neuropsychiatric sequelae of mercury poisoning. The Mad Hatter's disease revisited (1995)
Journal Article
O'Carroll, R. E., Masterton, G., Dougall, N., Ebmeier, K. P., & Goodwin, G. M. (1995). The neuropsychiatric sequelae of mercury poisoning. The Mad Hatter's disease revisited. British Journal of Psychiatry, 167(1), 95-98. doi:10.1192/bjp.167.1.95

BACKGROUND The detailed effects of mercury poisoning on cognitive function, brain anatomy and regional brain function are largely unknown. We report the case of a 38-year-old man who was exposed to toxic levels of inorganic mercury.

METHOD Four ye... Read More about The neuropsychiatric sequelae of mercury poisoning. The Mad Hatter's disease revisited.

Uptake of99mTc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls (1994)
Journal Article
Edmonstone, Y., Austin, M., Prentice, N., Dougall, N., Freeman, C. P. L., Ebmeier, K. P. & Goodwin, G. M. (1994). Uptake of99mTc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls. Acta psychiatrica Scandinavica. 90. (4). 298-303. doi:10.1111/j.1600-0447.1994.tb01597.x. ISSN 0001-690X.

Twelve patients with obsessive-compulsive disorder (OCD) were investigated at rest using single photon emission computerized tomography with 99mTc-exametazime. The uptake of 99mTc-exametazime was expressed relative to calcarine/occipital cortex. Pati... Read More about Uptake of99mTc-exametazime shown by single photon emission computerized tomography in obsessive-compulsive disorder compared with major depression and normal controls.

PASAT performance and the pattern of uptake of 99mTc-exametazime in brain estimated with single photon emission tomography. (1994)
Journal Article
Deary, I. J., Ebmeier, K. P., MacLeod, K. M., Dougall, N., Hepburn, D. A., Frier, B. M. & Goodwin, G. M. (1994). PASAT performance and the pattern of uptake of 99mTc-exametazime in brain estimated with single photon emission tomography. Biological Psychology. 38. (1). 1-18. doi:10.1016/0301-0511(94)90046-9. ISSN 0301-0511.

The effect of the paced auditory serial addition test (PASAT) on the regional uptake of 99mTc-exametazime was determined by single photon emission computed tomography. Twenty insulin-treated diabetic outpatients were scanned at rest and during the pe... Read More about PASAT performance and the pattern of uptake of 99mTc-exametazime in brain estimated with single photon emission tomography..

Single photon emission computed tomography in long-term survivors of adult brain tumours. (1994)
Journal Article
Ebmeier, K. P., Booker, K., Gregor, A., Cull, A., Dougall, N., Sellar, R., & Goodwin, G. M. (1994). Single photon emission computed tomography in long-term survivors of adult brain tumours. Journal of Neurology, Neurosurgery and Psychiatry, 57(6), 729-733. https://doi.org/10.1136/jnnp.57.6.729

Sixteen patients with primary brain tumours were examined on average eight years after treatment with surgery or whole brain irradiation using standard clinical assessment, CT, a neuropsychological test battery, and single photon emission CT (SPECT)... Read More about Single photon emission computed tomography in long-term survivors of adult brain tumours..

Regional cerebral blood flow in IDDM patients: effects of diabetes and of recurrent severe hypoglycaemia (1994)
Journal Article
MacLeod, K. M., Hepburn, D. A., Deary, I. J., Goodwin, G. M., Dougall, N., Ebmeier, K. P. & Frier, B. M. (1994). Regional cerebral blood flow in IDDM patients: effects of diabetes and of recurrent severe hypoglycaemia. Diabetologia. 37. (3). 257-263. doi:10.1007/s001250050103. ISSN 0012-186X.

Chronic hyperglycaemia and recurrent severe hypoglycaemia have both been implicated as causing cerebral damage in patients with diabetes. Although cognitive dysfunction and intellectual impairment have been demonstrated in patients with recurrent sev... Read More about Regional cerebral blood flow in IDDM patients: effects of diabetes and of recurrent severe hypoglycaemia.

Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis (1994)
Journal Article
Moffoot, A., O'Carroll, R. E., Murray, C., Dougall, N., Ebmeier, K. & Goodwin, G. M. (1994). Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis. Psychological Medicine. 24. (01). 53. doi:10.1017/s0033291700026829. ISSN 0033-2917.

The effects upon regional brain function of infusing either saline or clonidine (1·5μg/kg) has been examined in 18 patients with alcoholic Korsakoff's psychosis using 99mTc-hexamethylpropyleneamineoxime (99mTc-HMPAO or 99mTc-Exametazime) and Single P... Read More about Clonidine infusion increases uptake of 99mTc-Exametazime in anterior cingulate cortex in Korsakoff's psychosis.

Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography (1994)
Journal Article
Scott, A. I. F., Dougall, N., Ross, M., O'Carroll, R. E., Riddle, W., Ebmeier, K. P. & Goodwin, G. M. (1993). Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography. Journal of Affective Disorders. 30. (1). 27-34. doi:10.1016/0165-0327(94)90148-1. ISSN 0165-0327.

Fifteen patients with major depression who were being treated with bilateral electroconvulsive treatment (ECT) were investigated before and 45 min after a single ECT using split-dose Single Photon Emission Tomography (SPET or SPECT) with 99mTc-Examet... Read More about Short-term effects of electroconvulsive treatment on the uptake of99mTc-Exametazime into brain in major depression shown with single photon emission tomography.

State changes in brain activity shown by the uptake of 99mTc-exametazime with single photon emission tomography in major depression before and after treatment (1993)
Journal Article
Goodwin, G. M., Austin, M., Dougall, N., Ross, M., Murray, C., O'Caroll, R. E., …Ebmeier, K. P. (1993). State changes in brain activity shown by the uptake of 99mTc-exametazime with single photon emission tomography in major depression before and after treatment. Journal of Affective Disorders. 29. (4). 243-253. doi:10.1016/0165-0327(93)90014-b. ISSN 0165-0327.

Twenty-eight patients with a major depressive episode previously investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, were followed up at an interval of 9–28 months with the same investigation after ful... Read More about State changes in brain activity shown by the uptake of 99mTc-exametazime with single photon emission tomography in major depression before and after treatment.

A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia. (1993)
Journal Article
Riddle, W., O'Carroll, R. E., Dougall, N., Van Beck, M., Murray, C., Curran, S. M., Ebmeier, K. P., & Goodwin, G. M. (1993). A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia. British Journal of Psychiatry, 163(2), 166-172. https://doi.org/10.1192/bjp.163.2.166

Ten patients with Alzheimer-type dementia and nine age-matched normal controls were examined with SPECT, using split-dose 99mTc-labelled exametazime. The baseline condition involved repetition of the word 'yes' or 'no'. The activation condition invol... Read More about A single photon emission computerised tomography study of regional brain function underlying verbal memory in patients with Alzheimer-type dementia..

A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia (1993)
Journal Article
Curran, S. M., Murray, C. M., Van Beck, M., Dougall, N., O'Carroll, R. E., Austin, M. P., Ebmeier, K. P., & Goodwin, G. M. (1993). A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia. British Journal of Psychiatry, 163(2), 155-165. https://doi.org/10.1192/bjp.163.2.155

The uptake, at rest, of 99mTc-exametazime into different brain regions was compared using SPECT for 20 elderly subjects with major depressive disorder, 20 with Alzheimer-type dementia, and 30 age-matched normal volunteers. Uptake was referred to calc... Read More about A single photon emission computerised tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia.

The effect of anxiety induction on the regional uptake of 99mTc-Exametazime in simple phobia as shown by single photon emission tomography (SPET) (1993)
Journal Article
O'Carroll, R. E., Moffoot, A. P. R., Van Beck, M., Dougall, N., Murray, C., Ebmeier, K. P. & Goodwin, G. M. (1993). The effect of anxiety induction on the regional uptake of 99mTc-Exametazime in simple phobia as shown by single photon emission tomography (SPET). Journal of Affective Disorders. 28. (3). 203-210. doi:10.1016/0165-0327(93)90106-t. ISSN 0165-0327.

Ten patients suffering from DSM-III-R simple phobia were studied under two conditions: (a) while listening to a 4 min relaxation tape, and (b) while listening to a 4 min audio tape describing exposure to the phobic stimulus. During each condition, su... Read More about The effect of anxiety induction on the regional uptake of 99mTc-Exametazime in simple phobia as shown by single photon emission tomography (SPET).

Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients (1993)
Journal Article
Ebmeier, K. P., Blackwood, D. H. R., Murray, C., Souza, V., Walker, M., Dougall, N., …Goodwin, G. M. (1993). Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients. Biological Psychiatry. 33. (7). 487-495. doi:10.1016/0006-3223(93)90002-u. ISSN 0006-3223.

We examined 20 actively psychotic unmedicated schizophrenic patients and 20 matched control subjects by using single-photon emission, computed tomography (SPECT) with 99mtechnetium-exametazime. Patients showed a hyperfrontal pattern of tracer uptake... Read More about Single-photon emission computed tomography with 99mTc-exametazime in unmediated schizophrenic patients.

Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum (1992)
Journal Article
Austin, M., Dougall, N., Ross, M., Murray, C., O'Carroll, R. E., Moffoot, A., …Goodwin, G. M. (1992). Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum. Journal of Affective Disorders. 26. (1). 31-43. doi:10.1016/0165-0327(92)90032-2. ISSN 0165-0327.

Forty patients with a major depressive episode were investigated at rest using Single Photon Emission Tomography (SPET or SPECT) with 99mTc-exametazime, an intravenous ligand taken into brain in proportion to regional cerebral blood flow, thereby pro... Read More about Single photon emission tomography with 99mTc-exametazime in major depression and the pattern of brain activity underlying the psychotic/neurotic continuum.

Regional cerebral blood flow and cognitive function in patients with chronic liver disease (1991)
Journal Article
O'Carroll, R. E., Ebmeier, K. P., Dougall, N., Murray, C., Goodwin, G. M., Hayes, P. C., …Best, J. J. K. (1991). Regional cerebral blood flow and cognitive function in patients with chronic liver disease. Lancet. 337. (8752). 1250-1253. doi:10.1016/0140-6736(91)92920-w. ISSN 0140-6736.

Subtle impairments of cognitive function may be an important cause of occupational and psychosocial morbidity in patients with chronic liver disease. Correlation of structural brain abnormalities with cognitive deficits has yielded inconsistent resul... Read More about Regional cerebral blood flow and cognitive function in patients with chronic liver disease.

Childhood adversity, mental health and suicide (CHASE): a longitudinal case-control linked data study of lifetime inpatient records associated with suicide
Presentation / Conference Contribution
Savinc, J. (2022, March). Childhood adversity, mental health and suicide (CHASE): a longitudinal case-control linked data study of lifetime inpatient records associated with suicide. Paper presented at 2022 Mental Health Data Science meeting, Online

Background
Childhood adversity (CA) carries an increased risk of developing later mental health (MH) problems and suicidal behaviour. This study aimed to summarise hospital attendances for CA and MH in young people who later died by suicide.
Method... Read More about Childhood adversity, mental health and suicide (CHASE): a longitudinal case-control linked data study of lifetime inpatient records associated with suicide.

Impact of Childhood Adversity and mental health on young person suicide: the CHASE study
Presentation / Conference Contribution
Dougall, N., Heyman, I., Savinc, J., Abbott-Smith, S., & Murray, J. (2023, May). Impact of Childhood Adversity and mental health on young person suicide: the CHASE study. Paper presented at European Conference on Law Enforcement and Public Health, Umeå, Sweden

Background
Suicide rates have been increasing in recent years after a period of decline since the 1990s, with notable increases in those aged 15-24. Childhood adversity is a known risk factor for later suicide.

Research objectives
We aimed to fi... Read More about Impact of Childhood Adversity and mental health on young person suicide: the CHASE study.