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Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training (2023)
Journal Article
Yasar, Z., Ross, M. D., Gaffney, C. J., Postlethwaite, R. D., Wilson, R., & Hayes, L. D. (2023). Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training. Pflügers Archiv European Journal of Physiology, 475(4), 465-475. https://doi.org/10.1007/s00424-022-02785-6

Older adults exhibit a reduced number and function of CD34 + circulating progenitor cells (CPC), a known risk factor for cardiovascular disease. Exercise promotes the mobilisation of CPCs from bone marrow, so whether ageing per se or physical inactiv... Read More about Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training.

Spontaneous coronary artery dissection: a systematic review of physical and psychosocial recovery following discharge from hospital (2022)
Journal Article
Neubeck, L., McHale, S., Ross, M., MacGillvray, S., Galbraith, M., & Hanson, C. (2022). Spontaneous coronary artery dissection: a systematic review of physical and psychosocial recovery following discharge from hospital. European Journal of Cardiovascular Nursing, 21(7), 665-676. https://doi.org/10.1093/eurjcn/zvac009

Introduction Spontaneous coronary artery dissection (SCAD) is increasingly recognised as an important cause of myocardial infarction, particularly among women. SCAD survivors may not know what physical activity is safe and effective and there may be... Read More about Spontaneous coronary artery dissection: a systematic review of physical and psychosocial recovery following discharge from hospital.

Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation (2022)
Journal Article
Taylor, G. S., Shaw, A., Scragg, J. H., Smith, K., Campbell, M. D., Mcdonald, T. J., …West, D. J. (2022). Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation. Frontiers in Endocrinology, 13, Article 797438. https://doi.org/10.3389/fendo.2022.797438

Background: Many individuals with type 1 diabetes retain residual beta-cell function. Sustained endogenous insulin and C-peptide secretion is associated with reduced diabetes related complications, but underlying mechanisms remain unclear. Lower cir... Read More about Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation.

Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic (2021)
Journal Article
Mclaughlin, M., Florida-James, G., & Ross, M. (2021). Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic. Vascular Biology, 3(1), R106-R120. https://doi.org/10.1530/VB-21-0013

Breast cancer chemotherapy, although very potent against tumour tissue, results in significant cardiovascular toxicity. The focus of research in this area has been predominantly towards cardiotoxicity. There is limited evidence detailing the impact o... Read More about Breast cancer chemotherapy vascular toxicity: A review of mediating mechanisms and exercise as a potential therapeutic.

Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated (2021)
Journal Article
Taylor, G. S., Shaw, A., Smith, K., Capper, T. E., Scragg, J. H., Cronin, M., …West, D. J. (2021). Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated. Scientific Reports, 11, Article 14502. https://doi.org/10.1038/s41598-021-93886-2

Background: Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (EPCs) is completely lacking in type 1 diabetes (T1D). Clarification, along... Read More about Type 1 diabetes patients increase CXCR4+ and CXCR7+ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated.

CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients (2021)
Journal Article
Muggeridge, D., Dodd, J., & Ross, M. D. (2021). CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients. Atherosclerosis, 333, 108-115. https://doi.org/10.1016/j.atherosclerosis.2021.07.004

Background and aims Circulating progenitor cells (CPCs) play an important role in vascular repair and can influence cardiovascular (CV) health and longevity. Exercise is known to modulate these cells via mobilization from the bone marrow. The primar... Read More about CD34+ progenitors are predictive of mortality and are associated with physical activity in cardiovascular disease patients.

Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age (2021)
Journal Article
Lithgow, H., Florida‐James, G., Ross, M., Duncan, G., & Leggate, M. (2021). Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age. Experimental Physiology, 106(7), 1460-1469. https://doi.org/10.1113/ep089480

Vitamin D plays a key role in the modulation of the immune system, mediated through the intracellular vitamin D receptor (VDR). Exercise has been shown to influence the activity and availability of the VDR. This study aimed to investigate the effect... Read More about Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D-deficient men, independent of age.

The role of MSC therapy in attenuating the damaging effects of the cytokine storm induced by COVID-19 on the heart and cardiovascular system (2020)
Journal Article
Ellison-Hughes, G. M., Colley, L., O'Brien, K. A., Roberts, K. A., Agbaedeng, T. A., & Ross, M. (2020). The role of MSC therapy in attenuating the damaging effects of the cytokine storm induced by COVID-19 on the heart and cardiovascular system. Frontiers in Cardiovascular Medicine, 7, Article 602183. https://doi.org/10.3389/fcvm.2020.602183

The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19) has led to 47m infected cases and 1.2m (2.6%) deaths. A hallmark of more severe cases of SARS-CoV-2 in patients with a... Read More about The role of MSC therapy in attenuating the damaging effects of the cytokine storm induced by COVID-19 on the heart and cardiovascular system.

Vascular Manifestations of COVID-19 -Thromboembolism and Microvascular Dysfunction (2020)
Journal Article
Roberts, K. A., Colley, L., Agbaedeng, T. A., Ellison-Hughes, G. M., & Ross, M. D. (2020). Vascular Manifestations of COVID-19 -Thromboembolism and Microvascular Dysfunction. Frontiers in Cardiovascular Medicine, 7, Article 598400. https://doi.org/10.3389/fcvm.2020.598400

The coronavirus pandemic has reportedly infected over 22 million individuals and caused over 778,000 deaths worldwide. This novel coronavirus, officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), although primarily causes si... Read More about Vascular Manifestations of COVID-19 -Thromboembolism and Microvascular Dysfunction.

Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. (2019)
Journal Article
Montgomery, R., Paterson, A., Williamson, C., Florida-James, G., & Ross, M. D. (2019). Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men. Frontiers in Physiology, https://doi.org/10.3389/fphys.2019.00447

Endothelial progenitor cells (EPCs) are a vasculogenic subset of progenitors, which play a key role in maintenance of endothelial integrity. These cells are exercise-responsive, and thus exercise may play a key role in vascular repair and maintenance... Read More about Blood flow restriction exercise attenuates the exercise-induced endothelial progenitor cells in healthy, young men..

Circulating angiogenic cell response to sprint interval and continuous exercise. (2019)
Journal Article
O'Carroll, L., Wardrop, B., Murphy, R. P., Ross, M. D., & Harrison, M. (2019). Circulating angiogenic cell response to sprint interval and continuous exercise. European Journal of Applied Physiology, 119(3), 743-752. https://doi.org/10.1007/s00421-018-04065-7

Although commonly understood as immune cells, certain T lymphocyte and monocyte subsets have angiogenic potential, contributing to blood vessel growth and repair. These cells are highly exercise responsive and may contribute to the cardiovascular ben... Read More about Circulating angiogenic cell response to sprint interval and continuous exercise..

An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions (2019)
Journal Article
Smith, K., Muggeridge, D. J., Easton, C., & Ross, M. D. (2019). An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions. European Journal of Applied Physiology, 119(3), 723-733. https://doi.org/10.1007/s00421-018-04063-9

Purpose: Dietary nitrate (NO3-) has repeatedly been shown to improve endurance and intermittent, high-intensity events in temperate conditions. However, the ergogenic effects of dietary NO3- on intermittent exercise performance in hot conditions has... Read More about An acute dose of inorganic dietary nitrate does not improve high-intensity, intermittent exercise performance in temperate or hot and humid conditions.

Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity (2018)
Journal Article
Ross, M. D. (2018). Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity. Current Cardiology Reviews, 14(4), 233-244. https://doi.org/10.2174/1573403X14666180726112303

The endothelium plays an important role in cardiovascular regulation, from blood flow, to platelet aggregation, immune cell infiltration and demargination. A dysfunctional endothelium leads to the onset and progression of cardiovascular disease (CVD)... Read More about Endothelial Regenerative Capacity and Aging: Influence of Diet, Exercise and Obesity.

Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men (2018)
Journal Article
Ross, M., Ingram, L., Taylor, G., Malone, E., Simpson, R. J., West, D., & Florida-James, G. (2018). Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men. Physiological Reports, 6(12), Article e13697. https://doi.org/10.14814/phy2.13697

Aging is associated with elevated cardiovascular disease risk. As a result of aging, endothelial dysfunction develops, partly due to a reduction in vascular regenerative ability. CD31+ T-cells (angiogenic T-cells; TANG) possess highly angiogenic capa... Read More about Older men display elevated levels of senescence-associated exercise-responsive CD28null angiogenic T cells compared with younger men.

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations (2018)
Journal Article
Kemp, S., Young, L., Ross, M., Prach, M., Hutchison, G. R., Malone, E., & Fraser, J. A. (2018). Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations. Scientific Reports, 8(1), Article 7506. https://doi.org/10.1038/s41598-018-25854-2

Neutrophil surveillance is central to nanoparticle clearance. Silver nanoparticles (AgNP) have numerous uses, however conflicting evidence exists as to their impact on neutrophils and whether they trigger damaging inflammation. Neutrophil’s importanc... Read More about Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations.

Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men (2017)
Journal Article
Ross, M. D., Malone, E. M., Simpson, R., Cranston, I., Ingram, L., Wright, G. P., …Florida-James, G. D. (2018). Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men. American journal of physiology. Heart and circulatory physiology, 314(3), 392-402. https://doi.org/10.1152/ajpheart.00592.2017

Ageing is associated with a dysfunctional endothelial phenotype, as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating... Read More about Lower Resting and Exercise-Induced Circulating Angiogenic Progenitors and Angiogenic T-Cells in Older Men.

Vascular Ageing and Exercise: Focus on Cellular Reparative Processes (2016)
Journal Article
Ross, M. D., Malone, E., & Florida-James, G. (2016). Vascular Ageing and Exercise: Focus on Cellular Reparative Processes. Oxidative Medicine and Cellular Longevity, 2016, 1-15. https://doi.org/10.1155/2016/3583956

Ageing is associated with an increased risk of developing noncommunicable diseases (NCDs), such as diabetes and cardiovascular disease (CVD). The increased risk can be attributable to increased prolonged exposure to oxidative stress. Often, CVD is pr... Read More about Vascular Ageing and Exercise: Focus on Cellular Reparative Processes.