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Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia (2017)
Journal Article
Martín-Aragón Baudel, M. A. S., Rae, M. T., Darlison, M. G., Poole, A. V., & Fraser, J. A. (2017). Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia. PLOS ONE, 12(10), Article e0185664. https://doi.org/10.1371/journal.pone.0185664

Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxygen homeostasis and regulate specific aspects of hypoxic adaptation. Here we... Read More about Preferential activation of HIF-2α adaptive signalling in neuronal-like cells in response to acute hypoxia.

Chloride co-transporters as possible therapeutic targets for stroke (2016)
Journal Article
Martín-Aragón Baudel, M. A. S., Martín-Aragón Baudel, M. A. S., Poole, A. V., & Darlison, M. G. (2017). Chloride co-transporters as possible therapeutic targets for stroke. Journal of Neurochemistry, 140(2), 195-209. https://doi.org/10.1111/jnc.13901

Stroke is one of the major causes of death and disability worldwide. The major type of stroke is an ischaemic one, which is caused by a blockage that interrupts blood flow to the brain. There are currently very few pharmacological strategies to red... Read More about Chloride co-transporters as possible therapeutic targets for stroke.

Can laboratory based research regarding type 1 diabetes and exercise be applied into the real-life environment? (2015)
Journal Article
Charlton, J., Kilbride, L., MacLean, R., Darlison, M. G., & McKnight, J. (2015). Can laboratory based research regarding type 1 diabetes and exercise be applied into the real-life environment?. Practical Diabetes, 32(6), 217-221. https://doi.org/10.1002/pdi.1961

The aim of this study was to determine whether results from laboratory based research examining glycaemic control during and after exercise can be applied to a real-life (non-laboratory) environment. A comparative study of individuals with type 1 dia... Read More about Can laboratory based research regarding type 1 diabetes and exercise be applied into the real-life environment?.

Delayed hypoglycaemia in people with type 1 diabetes after performing moderate intensity exercise before the evening meal (2015)
Journal Article
Charlton, J., Kilbride, L., MacLean, R., Darlison, M. G., & McKnight, J. (2015). Delayed hypoglycaemia in people with type 1 diabetes after performing moderate intensity exercise before the evening meal. Practical Diabetes, 32(3), 99-102. https://doi.org/10.1002/pdi.1933

For a person with type 1 diabetes, participation in exercise may increase the risk of hypoglycaemia. Research has been performed during or immediately after exercise in a laboratory environment, with limited evidence regarding strategies for post-e... Read More about Delayed hypoglycaemia in people with type 1 diabetes after performing moderate intensity exercise before the evening meal.

The design and evaluation of a self-management algorithm for people with type 1 diabetes performing moderate intensity exercise (2015)
Journal Article
Charlton, J., Kilbride, L., MacLean, R., Darlison, M. G., & McKnight, J. (2015). The design and evaluation of a self-management algorithm for people with type 1 diabetes performing moderate intensity exercise. Practical Diabetes, 32(2), 64-69. https://doi.org/10.1002/pdi.1926

Limited evidence is available to advise people with type 1 diabetes about self-management strategies for maintaining acceptable glycaemic control when exercising. A systematic review was conducted to design a self-management algorithm for moderate... Read More about The design and evaluation of a self-management algorithm for people with type 1 diabetes performing moderate intensity exercise.

GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus (2013)
Journal Article
Darlison, M. G., Dos-Anjos, S., Llorente, I. L., Llorente, I. L., Perez-Rodriguez, D., Martínez-Villayandre, B., …Fernández-López, A. (2013). GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus. Brain Research, 1533, 141-151. https://doi.org/10.1016/j.brainres.2013.08.024

Assays on "ex vivo" sections of rat hippocampus and rat cerebral cortex, subjected to oxygen and glucose deprivation (OGD) and a three-hour reperfusion-like (RL) recovery, were performed in the presence of either GABA or the GABA(A) receptor binding... Read More about GABAA receptor chloride channels are involved in the neuroprotective role of GABA following oxygen and glucose deprivation in the rat cerebral cortex but not in the hippocampus.

Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats. (2012)
Journal Article
Montori, S., Dos Anjos, S., Poole, A. V., Regueiro-Purrinos, M. M., Llorente, I. L., Darlison, M. G., …Martínez-Villayandre, B. (2012). Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats. Neuropathology and Applied Neurobiology, 38, 710-722. https://doi.org/10.1111/j.1365-2990.2012.01254.x

Aims: This study has investigated how global brain ischaemia/reperfusion (I/R) modifies levels of mRNAs encoding GABA(A) receptor alpha1, beta2 and gamma2 subunits and glutamic acid decarboxylase 65 (GAD65) in an age- and structure-dependent manner.... Read More about Differential effect of transient global ischaemia on the levels of GABA(A) receptor subunit mRNAs in young and older rats..

The lack of associations between alleles at the hypoxia-Inducible factor 1A C1772T loci and responses to acute hypoxia (2010)
Journal Article
Hennis, P. J., Bussell, C., & Darlison, M. G. (2010). The lack of associations between alleles at the hypoxia-Inducible factor 1A C1772T loci and responses to acute hypoxia. Wilderness and Environmental Medicine, 21, 219-228. https://doi.org/10.1016/j.wem.2010.05.001

Objective The aim of this study was to investigate the associations between alleles of the hypoxia-inducible factor 1A (HIF1A) C1772T polymorphism and several physiological responses to hypoxia, including the hypoxic ventilatory response (HVR), an... Read More about The lack of associations between alleles at the hypoxia-Inducible factor 1A C1772T loci and responses to acute hypoxia.

Expression of the GABA(A) receptor gamma4-subunit gene in discrete nuclei within the zebra finch song system (2008)
Journal Article
Thode, C., Guettinger, H. R., & Darlison, M. G. (2008). Expression of the GABA(A) receptor gamma4-subunit gene in discrete nuclei within the zebra finch song system. Neuroscience, 157, 143-152. https://doi.org/10.1016/j.neuroscience.2008.08.057

The acquisition, production and maintenance of song by oscine birds is a form of audition-dependent learning that, in many ways, resembles the process by which humans learn to speak. In songbirds, the generation of structured song is determined by th... Read More about Expression of the GABA(A) receptor gamma4-subunit gene in discrete nuclei within the zebra finch song system.

Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit (2005)
Journal Article
Jones, A. K. M., Marshall, A., Darlison, M., Blake, A., Buckingham, S., Darlison, M., & Sattelle, D. (2005). Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit. Invertebrate Neuroscience, 5(3-4), 147-155. https://doi.org/10.1007/s10158-005-0007-6

The cloning, sequencing and functional expression of Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor (nAChR) subunit is described. This subunit shows 80% identity with the Drosophila melanogaster Dβ1 and 92% identi... Read More about Sgβ1, a novel locust (Schistocerca gregaria) non-α nicotinic acetylcholine receptor-like subunit with homology to the Drosophila melanogaster Dβ1 subunit.

Consequences of the Evolution of the GABAA Receptor Gene Family (2005)
Journal Article
Darlison, M. G., Pahal, I., & Thode, C. (2005). Consequences of the Evolution of the GABAA Receptor Gene Family. Cellular and Molecular Neurobiology, 25(3-4), 607-624. https://doi.org/10.1007/s10571-005-4004-4

1. This paper reviews the evolution of the family of genes present in mammals and other vertebrates that encode $γ$-aminobutyric acid (GABA) type A (GABAA) receptors, which are the major inhibitory neurotransmitter receptors in the central nervous sy... Read More about Consequences of the Evolution of the GABAA Receptor Gene Family.

Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick (2005)
Journal Article
Bock, J., Thode, C., Hannemann, O., Braun, K., & Darlison, M. (2005). Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick. Neuroscience, 133(3), 625-633. https://doi.org/10.1016/j.neuroscience.2005.02.048

We have cloned a full-length complementary {DNA} from the chicken (Gallus gallus domesticus), which encodes a polypeptide that exhibits ∼75% identity to the product of the mammalian gene Arc (activity-regulated cytoskeleton-associated protein), also... Read More about Early socio-emotional experience induces expression of the immediate-early gene Arc/arg3.1 (activity-regulated cytoskeleton-associated protein/activity-regulated gene) in learning-relevant brain regions of the newborn chick.

The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus (2004)
Journal Article
Thode, C., Bock, J., Braun, K., & Darlison, M. (2005). The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus. Neuroscience, 130(3), 611-617. https://doi.org/10.1016/j.neuroscience.2004.10.015

The immediate-early gene zenk (an acronym for the avian orthologue of the mammalian genes zif-268, egr-1, ngfi-a and krox-24) has been extensively employed, in studies on oscine birds, as a marker of neuronal activity to reveal forebrain structures t... Read More about The chicken immediate-early gene ZENK is expressed in the medio-rostral neostriatum/hyperstriatum ventrale, a brain region involved in acoustic imprinting, and is up-regulated after exposure to an auditory stimulus.

Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish (2001)
Journal Article
Pohl, S., Darlison, M. G., Clarke, W., Lederis, K., & Richter, D. (2001). Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish. European Journal of Pharmacology, 430(2-3), 193-202. https://doi.org/10.1016/S0014-2999%2801%2901391-7

Although it is well established that fish possess corticotropin-releasing factor (CRF) and a CRF-like peptide, urotensin I, comparatively little is known about the pharmacology of their cognate receptors. Here we report the isolation and functional e... Read More about Cloning and functional pharmacology of two corticotropin-releasing factor receptors from a teleost fish.

Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit (2001)
Journal Article
Forster, I. C., Harvey, R. J., Darlison, M. G., & Benson, J. A. (2001). Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit. European Journal of Pharmacology, 419(1), 1-7. https://doi.org/10.1016/S0014-2999%2801%2900964-5

The functional pharmacology of receptors composed of the chicken brain {GABAA} receptor γ4 subunit and the mammalian {GABAA} receptor α3 and β2 subunits was studied by heterologous expression in Xenopus laevis oocytes using the two electrode voltage-... Read More about Functional pharmacology of GABAA receptors containing the chicken brain γ4 subunit.

The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First? (1999)
Book Chapter
Darlison, M. G., & Richter, D. (1999). The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?. In D. Richter (Ed.), Regulatory Peptides and Cognate Receptors (1-11). Berlin: Springer. https://doi.org/10.1007/978-3-540-49421-8_1

As will be evident from the other chapters in this Volume, small peptide molecules regulate a wide variety of biological processes in both vertebrate and invertebrate species. For each bioactive peptide there exists one or more specific membrane-boun... Read More about The ‘Chicken and Egg’ Problem of Co-evolution of Peptides and Their Cognate Receptors: Which Came First?.

Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3 (1999)
Journal Article
Bailey, M. E., Albrecht, B. E., Johnson, K. J., & Darlison, M. G. (1999). Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3. BBA - Gene Structure and Expression, 1447(2-3), 307-312. https://doi.org/10.1016/s0167-4781%2899%2900167-0

{GABAC} receptors mediate rapid inhibitory neurotransmission in retina. We have mapped, in detail, the human genes which encode the three polypeptides that comprise this receptor: ρ1 (GABRR1), ρ2 (GABRR2) and ρ3 (GABRR3). We show that {GABRR1} and {G... Read More about Genetic linkage and radiation hybrid mapping of the three human GABAC receptor ρ subunit genes: GABRR1, GABRR2 and GABRR3.

Multiple genes for neuropeptides and their receptors: co-evolution and physiology (1999)
Journal Article
Darlison, M. G., & Richter, D. (1999). Multiple genes for neuropeptides and their receptors: co-evolution and physiology. Trends in Neurosciences, 22(2), 81-88. https://doi.org/10.1016/S0166-2236%2898%2901333-2

It is now well established that neuropeptide receptors, which are present throughout the {CNS} and in peripheral tissues, frequently exist in a variety of different forms (called subtypes), each of which is encoded by a distinct gene. With the recent... Read More about Multiple genes for neuropeptides and their receptors: co-evolution and physiology.

Expression of the GABAA receptor gamma4-subunit gene: anatomical distribution of the corresponding mRNA in the domestic chick forebrain and the effect of imprinting training (1998)
Journal Article
Harvey, R. J., McCabe, B. J., Solomonia, R. O., Horn, G., & Darlison, M. G. (1998). Expression of the GABAA receptor gamma4-subunit gene: anatomical distribution of the corresponding mRNA in the domestic chick forebrain and the effect of imprinting training. The European journal of neuroscience, 10(9), 3024-3028. https://doi.org/10.1046/j.1460-9568.1998.00354.x

The learning process of imprinting involves morphological, electrophysiological and biochemical changes in a region of the chick (Gallus gallus domesticus) forebrain known as the intermediate and medial part of the hyperstriatum ventrale (IMHV). The... Read More about Expression of the GABAA receptor gamma4-subunit gene: anatomical distribution of the corresponding mRNA in the domestic chick forebrain and the effect of imprinting training.