All Outputs (2)

Relationship between Androgen Action in the “Male Programming Window,” Fetal Sertoli Cell Number, and Adult Testis Size in the Rat (2008)
Journal Article
Scott, H. M., Hutchison, G. R., Jobling, M. S., McKinnell, C., Drake, A. J., & Sharpe, R. M. (2008). Relationship between Androgen Action in the “Male Programming Window,” Fetal Sertoli Cell Number, and Adult Testis Size in the Rat. Endocrinology, 149, 5280-5287. https://doi.org/10.1210/en.2008-0413

Fetal androgen action is an important determinant of Sertoli cell (SC) number at birth. Androgens “program” reproductive tract development in rats between embryonic d (e) 15.5 and e17.5 (“male programming window”), and this is reflected for life by a... Read More about Relationship between Androgen Action in the “Male Programming Window,” Fetal Sertoli Cell Number, and Adult Testis Size in the Rat.

Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism (2008)
Journal Article
Welsh, M., Saunders, P. T. K., Fisken, M., Scott, H. M., Hutchison, G. R., Smith, L. B., & Sharpe, R. M. (2008). Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism. Journal of Clinical Investigation, 118(4), 1479-1490. https://doi.org/10.1172/JCI34241

Becoming a phenotypic male is ultimately determined by androgen-induced masculinization. Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear. Together with the adult-onset disord... Read More about Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism.