All Outputs (5)

Evolution and immunopathology of chikungunya virus informs therapeutic development (2023)
Journal Article
Henderson Sousa, F., Ghaisani Komarudin, A., Findlay-Greene, F., Bowolaksono, A., Sasmono, R. T., Stevens, C., & Barlow, P. G. (2023). Evolution and immunopathology of chikungunya virus informs therapeutic development. Disease Models and Mechanisms, 16(4), https://doi.org/10.1242/dmm.049804

Chikungunya virus (CHIKV), a mosquito-borne alphavirus, is an emerging global threat identified in more than 60 countries across continents. The risk of CHIKV transmission is rising due to increased global interactions, year-round presence of mosquit... Read More about Evolution and immunopathology of chikungunya virus informs therapeutic development.

The role of the human cathelicidin LL-37 in rhinovirus infection (2019)
Thesis
Henderson Sousa, F. The role of the human cathelicidin LL-37 in rhinovirus infection. (Thesis). Edinburgh Napier University. Retrieved from http://researchrepository.napier.ac.uk/Output/2070903

Human rhinoviruses (HRVs) are the most common causes for symptomatic respiratory infections, and have been linked to severe respiratory conditions in children, and in immunocompromised and elderly individuals. Currently there are no specific treatmen... Read More about The role of the human cathelicidin LL-37 in rhinovirus infection.

Antiviral therapeutic approaches for human rhinovirus infections (2018)
Journal Article
Casanova, V., Sousa, F. H., Stevens, C., & Barlow, P. G. (2018). Antiviral therapeutic approaches for human rhinovirus infections. Future Virology, https://doi.org/10.2217/fvl-2018-0016

Human rhinoviruses (RV) are the primary etiological agent of the common cold. This infection can be mild and self-limiting in immunocompetent hosts, but can be associated with bronchiolitis in infants, pneumonia in the immunosuppressed, and exacerba... Read More about Antiviral therapeutic approaches for human rhinovirus infections.

Cathelicidins display conserved direct antiviral activity towards rhinovirus. (2017)
Journal Article
Sousa, F. H., Casanova, V., Findlay, F., Stevens, C., Svoboda, P., Pohl, J., …Barlow, P. G. (2017). Cathelicidins display conserved direct antiviral activity towards rhinovirus. Peptides, 95, 76-83. https://doi.org/10.1016/j.peptides.2017.07.013

Human rhinoviruses (HRVs) are the most common cause of viral respiratory tract infections, and are associated with significant morbidity and mortality in immunocompromised individuals and patients with pre-existing pulmonary conditions. The therapeut... Read More about Cathelicidins display conserved direct antiviral activity towards rhinovirus..

Antiviral host defence peptides. (2016)
Book Chapter
Sousa, F. H., Casanova, V., Stevens, C., & Barlow, P. G. (2016). Antiviral host defence peptides. In R. M. Epand (Ed.), Host Defense Peptides and Their Potential as Therapeutic Agents, 57-94. Springer Verlag. https://doi.org/10.1007/978-3-319-32949-9_3

The on going global mortality and morbidity associated with viral pathogens highlights the need for the continued development of effective, novel antiviral molecules. The antiviral activity of cationic host defence peptides is of significant interest... Read More about Antiviral host defence peptides..