All Outputs (26)

Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial (2024)
Journal Article
Aitken, L. M., Emerson, L. M., Kydonaki, K., Blackwood, B., Creagh-Brown, B., Lone, N. I., …Walsh, T. S. (2024). Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial. BMJ Open, 14(4), Article e081637. https://doi.org/10.1136/bmjopen-2023-081637

Introduction An association between deep sedation and adverse short-term outcomes has been demonstrated although this evidence has been inconsistent. The A2B (alpha-2 agonists for sedation in critical care) sedation trial is designed to determine w... Read More about Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B trial): protocol for a mixed-methods process evaluation of a randomised controlled trial.

Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK (2023)
Journal Article
Walsh, T. S., Aitken, L. M., McKenzie, C. A., Boyd, J., Macdonald, A., Giddings, A., …Page, V. J. (2023). Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK. BMJ Open, 13(12), Article e078645. https://doi.org/10.1136/bmjopen-2023-078645

Introduction: Almost all patients receiving mechanical ventilation (MV) in intensive care units (ICUs) require analgesia and sedation. The most widely used sedative drug is propofol, but there is uncertainty whether alpha2-agonists are superior. The... Read More about Alpha 2 agonists for sedation to produce better outcomes from critical illness (A2B Trial): protocol for a multicentre phase 3 pragmatic clinical and cost-effectiveness randomised trial in the UK.

Patients’ experiences and perspectives of post-hospital follow-up care to improve physical recovery for intensive care survivors: A systematic review of qualitative research (2023)
Journal Article
Rea, N. M., Neubeck, L., McHale, S., & Kydonaki, K. (2023). Patients’ experiences and perspectives of post-hospital follow-up care to improve physical recovery for intensive care survivors: A systematic review of qualitative research. International Journal of Nursing Studies Advances, 5, Article 100168. https://doi.org/10.1016/j.ijnsa.2023.100168

Background Intensive care units deliver care to a heterogeneous group of patients with pre-existing co-morbid disease. Focus has shifted to improving health related quality of life with more patients surviving beyond hospital discharge. Randomised c... Read More about Patients’ experiences and perspectives of post-hospital follow-up care to improve physical recovery for intensive care survivors: A systematic review of qualitative research.

Improving antibiotic use in hospitals: development of a digital antibiotic review tracking toolkit (DARTT) using the behaviour change wheel (2023)
Journal Article
Wojcik, G., Ring, N., Willis, D., Williams, B., & Kydonaki, K. (in press). Improving antibiotic use in hospitals: development of a digital antibiotic review tracking toolkit (DARTT) using the behaviour change wheel. Psychology and Health, 1-21. https://doi.org/10.1080/08870446.2023.2182894

Objective To develop a theory-informed behaviour change intervention to promote appropriate hospital antibiotic use, guided by the Medical Research Council’s complex interventions framework. Methods A phased approach was used, including triang... Read More about Improving antibiotic use in hospitals: development of a digital antibiotic review tracking toolkit (DARTT) using the behaviour change wheel.

Cost and reimbursement analysis of end-of-life cancer inpatients. The case of the Greek public healthcare sector (2023)
Journal Article
Perdikouri, K., Katharaki, M., Kydonaki, K., Grammatopoulou, E., Baltopoulos, G., & Katsoulas, T. (2023). Cost and reimbursement analysis of end-of-life cancer inpatients. The case of the Greek public healthcare sector. Journal of Cancer Policy, 35, Article 100408. https://doi.org/10.1016/j.jcpo.2023.100408

Background While hospital-based Palliative Care services are usually covered through the main funding healthcare framework, traditional reimbursement methods have been criticized for their appropriateness. The present study investigates for the firs... Read More about Cost and reimbursement analysis of end-of-life cancer inpatients. The case of the Greek public healthcare sector.

Global collaboration in teaching root cause analysis with healthcare professional students (2022)
Journal Article
Hampe, H., Frndak, D., & Kydonaki, C. (2023). Global collaboration in teaching root cause analysis with healthcare professional students. Higher Education, Skills and Work-based Learning, 13(4), 772-785. https://doi.org/10.1108/heswbl-02-2022-0041

Purpose The purpose of this paper is to describe an example of how universities can develop unique synchronous educational opportunities to engage students in an online environment, especially since study abroad opportunities have slowed or halted d... Read More about Global collaboration in teaching root cause analysis with healthcare professional students.

Understanding the complexities of antibiotic prescribing behaviour in acute hospitals: a systematic review and meta-ethnography (2021)
Journal Article
Wojcik, G., Ring, N., McCulloch, C., Willis, D. S., Williams, B., & Kydonaki, K. (2021). Understanding the complexities of antibiotic prescribing behaviour in acute hospitals: a systematic review and meta-ethnography. Archives of Public Health, 79(1), Article 134. https://doi.org/10.1186/s13690-021-00624-1

Background: Antimicrobial resistance poses a serious global public health threat. Hospital misuse of antibiotics has contributed to this problem and evidence-based interventions are urgently needed to change inappropriate prescribing practices. Thi... Read More about Understanding the complexities of antibiotic prescribing behaviour in acute hospitals: a systematic review and meta-ethnography.

A mixed-methods feasibility study to assess the acceptability and applicability of immersive virtual reality sepsis game as an adjunct to nursing education (2021)
Journal Article
Adhikari, R., Kydonaki, C., Lawrie, J., O'Reilly, M., Ballantyne, B., Whitehorn, J., & Paterson, R. (2021). A mixed-methods feasibility study to assess the acceptability and applicability of immersive virtual reality sepsis game as an adjunct to nursing education. Nurse Education Today, 103, https://doi.org/10.1016/j.nedt.2021.104944

Abstract Background: Virtual Reality (VR) simulation has been a topic of interest in recent years as an innovative strategy for healthcare education. Although there are a handful of studies evaluating VR simulation on knowledge, motivation, and sati... Read More about A mixed-methods feasibility study to assess the acceptability and applicability of immersive virtual reality sepsis game as an adjunct to nursing education.

Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis (2021)
Journal Article
Aitken, L. M., Kydonaki, K., Blackwood, B., Trahair, L. G., Purssell, E., Sekhon, M., & Walsh, T. S. (2021). Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis. Thorax, 76(11), 1089-1098. https://doi.org/10.1136/thoraxjnl-2020-216098

Purpose: To determine the effect of depth of sedation on intensive care mortality, duration of mechanical ventilation, and other clinically important outcomes. Methods: We searched MEDLINE, Embase, CENTRAL, CINAHL, PsycINFO from 2000 - 2020. Ran... Read More about Inconsistent relationship between depth of sedation and intensive care outcome: systematic review and meta-analysis.

Family ward rounds in Intensive Care: an integrative review of the literature (2020)
Journal Article
Kydonaki, K., Takashima, M., & Mitchell, M. (2021). Family ward rounds in Intensive Care: an integrative review of the literature. International Journal of Nursing Studies, 113, Article 103771. https://doi.org/10.1016/j.ijnurstu.2020.103771

Background The involvement of family members in the ward rounds is a novel but under-researched family-centered care intervention in adult intensive care units, with limited evidence on the impact it has on patient and family-centered outcomes. O... Read More about Family ward rounds in Intensive Care: an integrative review of the literature.

Family INvolvement in inTensive care: A qualitative exploration of critically ill patients, their families and critical care nurses (INpuT study) (2020)
Journal Article
Kydonaki, K., Kean, S., & Tocher, J. (2020). Family INvolvement in inTensive care: A qualitative exploration of critically ill patients, their families and critical care nurses (INpuT study). Journal of Clinical Nursing, 29(7-8), 1115-1128. https://doi.org/10.1111/jocn.15175

Aims and objectives To understand the different factors that impact on the involvement of adult family members in the care of critically ill patients from the perspective of patients, families and nurses, with the aim to inform the enactment of a pa... Read More about Family INvolvement in inTensive care: A qualitative exploration of critically ill patients, their families and critical care nurses (INpuT study).

Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units (2019)
Journal Article
Kydonaki, K., Hanley, J., Huby, G., Antonelli, J., & Walsh, T. (2019). Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units. BMJ Open, 9, Article e024549. https://doi.org/10.1136/bmjopen-2018-024549

Objectives: Various strategies to promote light sedation are highly recommended in recent guidelines, as deep sedation is associated with suboptimum patient outcomes. Yet, the challenges met by clinicians in delivering high-quality analgosedation is... Read More about Challenges and barriers to optimising sedation in intensive care: a qualitative study in eight Scottish intensive care units.

Patient and family centered actionable processes of care and performance measures for persistent and chronic critical illness: a systematic review. (2019)
Journal Article
Rose, L., Istanboulian, L., Allum, L., Burry, L., Dale, C., Hart, N., …Connolly, B. (2019). Patient and family centered actionable processes of care and performance measures for persistent and chronic critical illness: a systematic review. Critical Care Explorations, 1(4), Article e0005. https://doi.org/10.1097/CCE.0000000000000005

Objective To identify actionable processes of care, quality indicators, or performance measures and their evidence base relevant to patients with persistent or chronic critical illness and their family members including themes relating to patient/fa... Read More about Patient and family centered actionable processes of care and performance measures for persistent and chronic critical illness: a systematic review..

Frightening and Traumatic Memories Early After Intensive Care Discharge (2018)
Journal Article
on behalf of the DESIST Investigators, Train, S., Kydonaki, K., Rattray, J., Stephen, J., Weir, C. J., & Walsh, T. S. (2019). Frightening and Traumatic Memories Early After Intensive Care Discharge. American Journal of Respiratory and Critical Care Medicine, 199(1), 120-121. https://doi.org/10.1164/rccm.201804-0699le

No abstract available.

Counselling for patients and families after intensive care: a feasibility study and mixed methods evaluation (2018)
Presentation / Conference
Ramsay, P., Kydonaki, C., Jailobaeva, K., McQuillan, L., & Walsh, T. (2018, March). Counselling for patients and families after intensive care: a feasibility study and mixed methods evaluation. Presented at NHS Lothian NMAHP Conference, 2018, NHS Lothian

No abstract available.

Patient- and family-centered performance measures focused on actionable processes of care for persistent and chronic critical illness: protocol for a systematic review (2017)
Journal Article
Rose, L., Istanboulian, L., Allum, L., Burry, L., Dale, C., Hart, N., …Connolly, B. (2017). Patient- and family-centered performance measures focused on actionable processes of care for persistent and chronic critical illness: protocol for a systematic review. Systematic Reviews, 6, https://doi.org/10.1186/s13643-017-0476-9

Background: Approximately 5 to 10% of critically ill patients transition from acute critical illness to a state of persistent and in some cases chronic critical illness. These patients have unique and complex needs that require a change in the clin... Read More about Patient- and family-centered performance measures focused on actionable processes of care for persistent and chronic critical illness: protocol for a systematic review.

An integrative review of factors influencing the use of antibiotic de-escalation in hospital setting (2017)
Presentation / Conference
Wojcik, G., Kydonaki, C., Willis, D., & Williams, B. (2017, March). An integrative review of factors influencing the use of antibiotic de-escalation in hospital setting. Poster presented at Edinburgh Antimicrobial Resistance Research Symposium, Edinburgh

No abstract available.

Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial (2016)
Journal Article
Walsh, T. S., Kydonaki, K., Antonelli, J., Stephen, J., Lee, R. J., Everingham, K., …Weir, C. J. (2016). Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial. Lancet Respiratory Medicine, 4(10), 807-817. https://doi.org/10.1016/s2213-2600%2816%2930178-3

Staff education, regular sedation and analgesia quality feedback, and a sedation monitoring technology for improving sedation and analgesia quality for critically ill, mechanically ventilated patients: a cluster randomised trial.

Development of process control methodology for tracking the quality and safety of pain, agitation and sedation management in critical care units (2016)
Journal Article
Walsh, T. S., Kydonaki, K., Lee, R. J., Everingham, K., Antonelli, J., Harkness, R. T., …Weir, C. J. (2016). Development of process control methodology for tracking the quality and safety of pain, agitation and sedation management in critical care units. Critical Care Medicine, 44(3), 564-574. https://doi.org/10.1097/CCM.0000000000001463

Objective: To develop sedation, pain, and agitation quality measures using process control methodology and evaluate their properties in clinical practice. Design: A Sedation Quality Assessment Tool was developed and validated to capture data for 1... Read More about Development of process control methodology for tracking the quality and safety of pain, agitation and sedation management in critical care units.

Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study) (2016)
Journal Article
Weir, C. J., Kydonaki, K., Walsh, T. S., Kydonaki, C. (., Antonelli, J., Stephen, J., …Weir, C. (2016). Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study). BMJ Open, 6(3), Article e010148. https://doi.org/10.1136/bmjopen-2015-010148

Objectives To describe the rationale, design and methodology for a trial of three novel interventions developed to improve sedation-analgesia quality in adult intensive care units (ICUs). Participants and Setting 8 clusters, each a Scottish ICU. A... Read More about Rationale, design and methodology of a trial evaluating three strategies designed to improve sedation quality in intensive care units (DESIST study).