PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity
(2019)
Journal Article
Siddiqui, F. A., Alam, C., Ora, M., Sabt, A., Manoharan, G. B., Bindu, L., Okutachi, S., Catillon, M., Taylor, T., Abdelhafez, O. M., Lönnberg, H., Stephen, A. G., Papageorgiou, A. C., Virta, P., & Abankwa, D. (2020). PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity. ACS Omega, 5(1), 832-842. https://doi.org/10.1021/acsomega.9b03639
The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and t... Read More about PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity.