Rate of lumbar paravertebral muscle fat infiltration versus spinal degeneration in asymptomatic populations: an age-aggregated cross-sectional simulation study

Crawford, Rebecca; Volken, Thomas; Valentin, Stephanie; Melloh, Markus; Elliott, James

Abstract

Background
The spinal column including its vertebrae and disks has been well examined and extensively reported in relation to age-aggregated degeneration. In contrast, paravertebral muscles are poorly represented in describing normative degeneration. Increasing evidence points to the importance of paravertebral muscle quality in low back health, and their potential as a modifiable factor in low back pain (LBP). Studies examining normative decline of paravertebral muscles are needed to advance the field’s etiological understanding. With a novel approach and based on published data, we establish and compare decline rates of imaging features for degeneration of lumbar vertebrae and disks, versus fatty infiltration in paravertebral muscles in asymptomatic adults.

Methods
Our cross-sectional simulation study examined age-aggregated data from three published studies who reported on asymptomatic adults spanning 18–60 years. Prevalence rates of imaging degenerative features of the spinal column were examined via logistic regression and compared with percentage fatty infiltration in erector spinae, multifidus and psoas using synthetic data and Monte Carlo simulation with 10,000 endpoint-specific regression iterations. General linear regression models were employed to estimate marginal effects of age reported as a one-year change rate (with 95 % confidence intervals) for comparisons between all reported spinal features.

Results
Declines in multifidus (0.24 & 0.11 %/year), erector spinae (0.13 & 0.07 %/year), and psoas (0.04 %/year) occur at similarly slow rates to disk protrusion (0.25 %/year), annular fissure (0.15 %/year), and spondylolisthesis (0.29 %/year). Multifidus showed a trend for faster decline than erector spinae, particularly in men. Of the features examined, disk signal loss declined fastest, and psoas muscle the slowest.

Conclusions
Degeneration of lumbar paravertebral muscles occurs slowly in asymptomatic adults, with a tendency to be most pronounced in multifidus. Rate of decline of spinal structures represents a novel variable that warrants inclusion as a known feature of the expected degenerative cascade, and to provide a basis for comparison to diseases of the spine in research and clinical practice. Concurrent examination of spinal features using advanced imaging to improve muscle analysis would be a strong addition to the field.

Citation

Crawford, R., Volken, T., Valentin, S., Melloh, M., & Elliott, J. (2016). Rate of lumbar paravertebral muscle fat infiltration versus spinal degeneration in asymptomatic populations: an age-aggregated cross-sectional simulation study. Scoliosis and Spinal Disorders, 11, Article 21. https://doi.org/10.1186/s13013-016-0080-0

• Journal Article Type: Article
• Acceptance Date: Jul 19, 2016
• Online Publication Date: Aug 5, 2016
• Publication Date: Aug 5, 2016
• Deposit Date: Feb 8, 2023
• Publicly Available Date: Feb 8, 2023
• Print ISSN: 2397-1789
• Electronic ISSN: 2397-1789
• Publisher: BMC
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Article Number: 21
• DOI: https://doi.org/10.1186/s13013-016-0080-0
• Keywords: Lumbar spine, Paravertebral muscles, Ageing, Multifidus, Erector spinae, Psoas, Disc degeneration, Asymptomatic adults, Magnetic resonance imaging, Fatty infiltration