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Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents

Ammar, Usama M.; Abdel-Maksoud, Mohammed S.; Oh, Chang-Hyun


Mohammed S. Abdel-Maksoud

Chang-Hyun Oh


Frequent oncogenic mutations have been identified in MAPK (mitogen-activated protein kinase) signaling pathway components. As a result, MAPK pathway is associated with human cancer initiation, in particular RAF (rapidly accelerated fibrosarcoma) component. The mutation in RAF component leads to auto-activation of MAPK signaling pathway, stimulating the uncontrolled cell growth and proliferation. In last few years, diverse chemical scaffolds have been identified as RAF inhibitors. Most of these scaffolds show potent anti-cancer activity. The present review highlights the recent investigations of RAF inhibitors during the last five years.


Ammar, U. M., Abdel-Maksoud, M. S., & Oh, C. (2018). Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry, 158, 144-166.

Journal Article Type Review
Acceptance Date Sep 3, 2018
Online Publication Date Sep 6, 2018
Publication Date 2018-10
Deposit Date Dec 11, 2022
Journal European Journal of Medicinal Chemistry
Print ISSN 0223-5234
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 158
Pages 144-166
Keywords MAPK, RAF inhibitors, Anti-cancer agents
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