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Time trends in 30 day case-fatality following hospitalisation for asthma in adults in Scotland: A retrospective cohort study from 1981 to 2009

Roberts, Nicola J.; Lewsey, James D.; Gillies, Michelle; Briggs, Andrew H.; Belozeroff, Vasily; Globe, Denise R.; Chiou, Chiun-Fang; Lin, Shao-Lee; Globe, Gary


James D. Lewsey

Michelle Gillies

Andrew H. Briggs

Vasily Belozeroff

Denise R. Globe

Chiun-Fang Chiou

Shao-Lee Lin

Gary Globe


The risk of case-fatality following hospitalisation for asthma has not been well characterised. We describe trends in 30 day case-fatality following hospitalisation for asthma in adults in Scotland from 1981 to 2009.
Using the Scottish Morbidity Record Scheme (SMR01) with all asthma hospitalisations for adults (≥18 years) with ICD9 493 and ICD10 J45–J46 in the principal diagnostic position at discharge (1981–2009). These data were linked to mortality data from the General Register Office for Scotland (GROS), with asthma case-fatality defined as death within 30 days of asthma admission (in or out of hospital). Logistic regression was used to explore the impact of age, sex, previous asthma admission (in the 12 months prior to hospitalisation), socioeconomic deprivation, year of admission and co-morbidity on 30-day case-fatality.
There were a total of 116 457 asthma hospitalisations; a total of 1000 (0.9%) hospitalisations resulted in a post-admission death (within 30 days of admission). Odds ratios for unadjusted and adjusted case-fatality showed a decreased risk of case-fatality from the mid-1990s onwards when compared to case-fatality in 1981. Advancing age and co-morbid diagnoses of respiratory failure, cancer, renal failure, cor pulmonale, coronary heart disease and respiratory infection were associated with increased likelihood of death.
30 day case-fatality has declined over the last three decades, comparable to case-fatality reported in other parts of the UK. This decline may be in part due to improved guidelines, protocols and disease management for asthma over the last 30 years. The likelihood of death 30 days following an asthma admission increased with age group and was associated with respiratory failure, renal failure and cancer.

Journal Article Type Article
Acceptance Date Apr 5, 2013
Online Publication Date May 6, 2013
Publication Date 2013-08
Deposit Date Aug 30, 2022
Journal Respiratory Medicine
Print ISSN 0954-6111
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 107
Issue 8
Pages 1172-1177
Keywords Asthma mortality, Asthma trends, Hospitalisations, Epidemiology
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