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Type 1 diabetes patients with different residual beta-cell function but similar age, HBA1c, and cardiorespiratory fitness have differing exercise-induced angiogenic cell mobilisation

Taylor, Guy S.; Shaw, Andy; Scragg, Jadine H.; Smith, Kieran; Campbell, Matthew D.; Mcdonald, Timothy J.; Shaw, James; Ross, Mark D.; West, Daniel J.


Guy S. Taylor

Andy Shaw

Jadine H. Scragg

Kieran Smith

Matthew D. Campbell

Timothy J. Mcdonald

James Shaw

Mark D. Ross

Daniel J. West


Many individuals with type 1 diabetes retain residual beta-cell function. Sustained endogenous insulin and C-peptide secretion is associated with reduced diabetes related complications, but underlying mechanisms remain unclear. Lower circulating numbers of
endothelial and hematopoietic progenitor cells (EPCs and HPCs), and the inability to increase the count of these cells in response to exercise, are also associated with increased diabetes complications and cardiovascular disease. It is unknown whether residual beta-cell function influences HPCs and EPCs. Thus, this study examined the influence of residual beta-cell function in type 1 diabetes upon exercise-induced changes in haematopoietic (HPCs) and endothelial progenitor cells (EPCs).
Participants with undetectable stimulated C-peptide (n=11; Cpepund), 10 high C-peptide (Cpephigh; >200 pmol/L), and 11
non-diabetes controls took part in this observational exercise study, completing 45 minutes of intensive walking at 60% VO2peak.
Clinically significant HPCs (CD34+) and EPCs (CD34+VEGFR2+) phenotypes for predicting future adverse cardiovascular outcomes, and subsequent cell surface expression of chemokine receptor 4 (CXCR4) and 7 (CXCR7), were enumerated at rest and immediately
post-exercise by flow cytometry.
Exercise increased HPCs and EPCs phenotypes similarly in the Cpephigh and control groups (+34-121% across phenotypes, p<0.04);
but Cpepund group did not significantly increase from rest, even after controlling for diabetes duration. Strikingly, the post-exercise Cpepund counts were still lower than Cpephigh at rest.
Residual beta-cell function is associated with an intact exercise-induced HPCs and EPCs mobilisation. As key characteristics (age, fitness, HbA1c) were similar between groups, the mechanisms underpinning the absent mobilisation within those with negative C-peptide, and the vascular implications, require further nvestigation.

Journal Article Type Article
Acceptance Date Jan 10, 2022
Online Publication Date Feb 11, 2022
Publication Date 2022
Deposit Date Jan 11, 2022
Publicly Available Date Jan 11, 2022
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 13
Article Number 797438
Keywords Residual beta-cell function, Haematopoietic progenitor cells, endothelial progenitor cells, Exercise, exercise-induced mobilisation
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