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Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study

Sheikh, Aziz; De Vries, Govert; Anto, Josep M.; Annesi?Maesano, Isabella; Wickman, Magnus; Hellings, Peter W.; Kuna, Piotr; Cruz, Alvaro A.; Zuberbier, Torsten; Pfaar, Oliver; Bergmann, Karl Christian; Kvedariene, Violeta; Todo?Bom, Ana Maria; Morais?Almeida, Mario; De Feo, Giulia; Bousquet, Jean; Ivancevich, Juan Carlos; Kalayci, Omer; Gemicio?lu, Bilun; Cingi, Cemal; O'Hehir, Robyn E.; Eller, Esben; Bindslev?Jensen, Carsten; Mel?n, Erik; Bachert, Claus; Toppila?Salmi, Sanna; Haahtela, Tari; Laune, Daniel; Fontaine, Jean?Fran?ois; Bosse, Isabelle; Reitsma, Sietze; Fokkens, Wytske J.; Samolinski, Boleslaw; Tomazic, Peter Valentin; Roller?Wirnsberger, Regina E.; Ryan, Dermot; Bewick, Mike; Prokopakis, Emmanuel P.; Papadopoulos, Nikos G.; Mullol, Joaquim; Cardona, Vicky; M?sges, Ralph; Klimek, Ludger; Valiulis, Arunas; Pereira, Ana Maria; Malva, Joao; Fonseca, Joao; Stellato, Cristiana; Illario, M.; Cecchi, Lorenzo; Larenas?Linnemann, D?sir?e; Orlando, Valentina; Keil, Thomas; Devillier,...

Authors

Aziz Sheikh

Govert De Vries

Josep M. Anto

Isabella Annesi?Maesano

Magnus Wickman

Peter W. Hellings

Piotr Kuna

Alvaro A. Cruz

Torsten Zuberbier

Oliver Pfaar

Karl Christian Bergmann

Violeta Kvedariene

Ana Maria Todo?Bom

Mario Morais?Almeida

Giulia De Feo

Jean Bousquet

Juan Carlos Ivancevich

Omer Kalayci

Bilun Gemicio?lu

Cemal Cingi

Robyn E. O'Hehir

Esben Eller

Carsten Bindslev?Jensen

Erik Mel�n

Claus Bachert

Sanna Toppila?Salmi

Tari Haahtela

Daniel Laune

Jean?Fran�ois Fontaine

Isabelle Bosse

Sietze Reitsma

Wytske J. Fokkens

Boleslaw Samolinski

Peter Valentin Tomazic

Regina E. Roller?Wirnsberger

Dermot Ryan

Mike Bewick

Emmanuel P. Prokopakis

Nikos G. Papadopoulos

Joaquim Mullol

Vicky Cardona

Ralph M�sges

Ludger Klimek

Arunas Valiulis

Ana Maria Pereira

Joao Malva

Joao Fonseca

Cristiana Stellato

M. Illario

Lorenzo Cecchi

D�sir�e Larenas?Linnemann

Valentina Orlando

Thomas Keil

Philippe Devillier

Wienczyslawa Czarlewski

Anna Bedbrook

Sylvie Arnavielhe

Rojin Rajabian?Soderlund

Vitalis Briedis

Slawomir Bialek

Ettore Novellino

Sinthia Bosnic?Anticevich

Luis Mid�o

Elisio Costa

Enrica Menditto



Abstract

Background
Mobile technology may help to better understand the adherence to treatment. MASK‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries.

Objectives
To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App.

Methods
An observational cross‐sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach.

Results
A total of 12 143 users were registered. A total of 6 949 users reported at least one VAS data recording. Among them, 1 887 users reported ≥7 VAS data. About 1 195 subjects were included in the analysis of adherence. One hundred and thirty‐six (11.28%) users were adherent (MPR ≥70% and PDC ≤1.25), 51 (4.23%) were partly adherent (MPR ≥70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non‐adherent to medications (MPR <70%). Of those, the largest group was non‐adherent to medications and the time interval was increased in 442 (36.68%) users.

Conclusion and clinical relevance
Adherence to treatment is low. The relative efficacy of continuous vs on‐demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication‐taking behaviour in a real‐world setting.

Citation

Sheikh, A., De Vries, G., Anto, J. M., Annesi‐Maesano, I., Wickman, M., Hellings, P. W., Kuna, P., Cruz, A. A., Zuberbier, T., Pfaar, O., Bergmann, K. C., Kvedariene, V., Todo‐Bom, A. M., Morais‐Almeida, M., De Feo, G., Bousquet, J., Ivancevich, J. C., Kalayci, O., Gemicioğlu, B., Cingi, C., …Menditto, E. (2019). Adherence to treatment in allergic rhinitis using mobile technology. The MASK Study. Clinical and Experimental Allergy, 49(4), 442-460. https://doi.org/10.1111/cea.13333

Journal Article Type Article
Acceptance Date Nov 7, 2018
Online Publication Date Mar 12, 2019
Publication Date 2019-04
Deposit Date May 3, 2021
Journal Clinical & Experimental Allergy
Print ISSN 0954-7894
Electronic ISSN 1365-2222
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 49
Issue 4
Pages 442-460
DOI https://doi.org/10.1111/cea.13333
Keywords adherence; mHealth; mobile technology observational study; rhinitis; treatment
Public URL http://researchrepository.napier.ac.uk/Output/2768555