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Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a

Turner, Marc L; Bessos, Hagop; Fagge, Timothy; Harkness, Mairi; Rentoul, Frances; Seymour, Janelle; Wilson, David; Gray, Irene; Ridheesh, Ahya; Cairns, John; Urnaniak, Stan

Authors

Marc L Turner

Hagop Bessos

Timothy Fagge

Mairi Harkness

Frances Rentoul

Janelle Seymour

David Wilson

Irene Gray

Ahya Ridheesh

John Cairns

Stan Urnaniak



Abstract

To assess the value of antenatal screening to detect neonatal alloimmune thrombocytopenia (NAIT) due to anti-HPA-1a, a prospective study was carried out to quantify the potential clinical benefits and determine whether screening would be cost-effective.
An observational prospective controlled study was carried out on 26,506 pregnant women over 2 years. HPA-1a phenotyping was performed in the first trimester and women confirmed HPA-1a-negative were tested for anti-HPA-1a during pregnancy, at delivery, and 10 to 14 days after birth. Babies of HPA-1a-negative women were tested at delivery for thrombocytopenia and examined for signs of bleeding. Economic evaluation was undertaken on the basis of the data collected during the study
Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a - ResearchGate. Available from: http://www.researchgate.net/publication/7400069_Prospective_epidemiologic_study_of_the_outcome_and_cost-effectiveness_of_antenatal_screening_to_detect_neonatal_alloimmune_thrombocytopenia_due_to_anti-HPA-1a [accessed Nov 13, 2015].

Citation

Turner, M. L., Bessos, H., Fagge, T., Harkness, M., Rentoul, F., Seymour, J., …Urnaniak, S. (2005). Prospective epidemiologic study of the outcome and cost-effectiveness of antenatal screening to detect neonatal alloimmune thrombocytopenia due to anti-HPA-1a. Transfusion, 45(12), 1945-1956. https://doi.org/10.1111/j.1537-2995.2005.00645.x

Journal Article Type Article
Acceptance Date May 2, 2005
Publication Date 2005-12
Deposit Date Nov 13, 2015
Print ISSN 0041-1132
Electronic ISSN 1537-2995
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 45
Issue 12
Pages 1945-1956
DOI https://doi.org/10.1111/j.1537-2995.2005.00645.x
Keywords Pregancy; ante-natail screening; child birth; blood transfusion
Public URL http://researchrepository.napier.ac.uk/id/eprint/9282
Publisher URL http://dx.doi.org/10.1111/j.1537-2995.2005.00645.x