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Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila (2016)
Journal Article
Wheelhouse, N., Flockhart, A., Aitchison, K., Livingstone, M., Finlayson, J., Flachon, V., …Longbottom, D. (2016). Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila. Scientific Reports, 6, 37150. https://doi.org/10.1038/srep37150

Waddlia chondrophila is a Gram-negative intracellular bacterial organism that is related to classical chlamydial species and has been implicated as a cause of abortion in cattle. Despite an increasing number of observational studies linking W. chondr... Read More about Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila.

Effect of Ozone Treatment on Inactivation of Escherichia coli and Listeria sp. on Spinach (2015)
Journal Article
Wani, S., Maker, J., Thompson, J., Barnes, J., & Singleton, I. (2015). Effect of Ozone Treatment on Inactivation of Escherichia coli and Listeria sp. on Spinach. Agriculture, 5(2), 155-169. https://doi.org/10.3390/agriculture5020155

The efficacy of “gaseous” ozone in reducing numbers and re-growth of food-borne pathogens, (Escherichia coli and Listeria spp.), on leafy salads was investigated using spinach. A preliminary in vivo study showed 1-log reduction in six strains of E. c... Read More about Effect of Ozone Treatment on Inactivation of Escherichia coli and Listeria sp. on Spinach.

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2 (2008)
Journal Article
Stevens, C., Pettersson, S., Wawrzynow, B., Wallace, M., Ball, K., Zylicz, A., & Hupp, T. R. (2008). ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2. FEBS Journal, 275(19), 4875-4886. https://doi.org/10.1111/j.1742-4658.2008.06627.x

Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit... Read More about ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1: ATP stimulated inhibition of E2F1 by MDM2.

Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides. (2006)
Journal Article
Taylor, C. M., Goldrick, M., Lord, L., & Roberts, I. S. (2006). Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides. Journal of Bacteriology, 188(3), 1165-1168. https://doi.org/10.1128/JB.188.3.1165-1168.2006

On the basis of increased resistance to K5 capsule-specific bacteriophage, a waaR transposon mutant defective in the biosynthesis of lipopolysaccharide outer core was isolated. In a K1-expressing strain the mutation equally affected sensitivity to K1... Read More about Mutations in the waaR Gene of Escherichia coli Which Disrupt Lipopolysaccharide Outer Core Biosynthesis Affect Cell Surface Retention of Group 2 Capsular Polysaccharides..

Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. (2006)
Journal Article
Soddell, J. A., Stainsby, F. M., Eales, K. L., Seviour, R. J., & Goodfellow, M. (2006). Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam. International Journal of Systematic and Evolutionary Microbiology, 56, 2265-2269. https://doi.org/10.1099/ijs.0.64034-0

Three strains of non-motile, Gram-positive, filamentous actinomycetes, isolates J4T, J5 and J59, initially recognized microscopically in activated sludge foam by their distinctive branching patterns, were isolated by micromanipulation. The taxonomic... Read More about Gordonia defluvii sp. nov., an actinomycete isolated from activated sludge foam..

Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. (2003)
Journal Article
Dancer, S. J., Robb, A., Crawford, A., & Morrison, D. (2003). Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections. Journal of Antimicrobial Chemotherapy, 51, 731-735. https://doi.org/10.1093/jac/dkg143

Objectives: Chronic methicillin-resistant Staphylococcus aureus (MRSA) infections in debilitated patients are difficult to treat. We studied the clinical efficacy and safety of an oral streptogramin, pristinamycin, for these patients. Patients an... Read More about Oral streptogramins in the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections..

Chk2 activates E2F-1 in response to DNA damage (2003)
Journal Article
Stevens, C., Smith, L., & La Thangue, N. B. (2003). Chk2 activates E2F-1 in response to DNA damage. Nature Cell Biology, 5(5), 401-409. https://doi.org/10.1038/ncb974

The E2F-1 transcription factor is regulated during cell cycle progression and induced by cellular stress, such as DNA damage. We report that checkpoint kinase 2 (Chk2) regulates E2F-1 activity in response to the DNA-damaging agent etoposide. A Chk2 c... Read More about Chk2 activates E2F-1 in response to DNA damage.

Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence (2002)
Journal Article
Taylor, C. M., Beresford, M., Epton, H. A. S., Sigee, D. C., Shama, G., Andrew, P. W., & Roberts, I. S. (2002). Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence. Journal of Bacteriology, 184(3), 621-628. https://doi.org/10.1128/JB.184.3.621-628.2002

We describe here the identification and characterization of two Listeria monocytogenes (Tn917-LTV3) relA and hpt transposon insertion mutants that were impaired in growth after attachment to a model surface. Both mutants were unable to accumulate (p)... Read More about Listeria monocytogenes relA and hpt Mutants Are Impaired in Surface-Attached Growth and Virulence.

Analysis of ammonia-oxidizing bacteria populations in acid forest soil during conditions of moisture limitation (2000)
Journal Article
Hastings, R. C., Butler, C., Singleton, I., Saunders, J. R., & McCarthy, A. J. (2000). Analysis of ammonia-oxidizing bacteria populations in acid forest soil during conditions of moisture limitation. Letters in applied microbiology, 30(1), 14-18. https://doi.org/10.1046/j.1472-765x.2000.00630.x

Ammonia-oxidizer numbers decreased under conditions of moisture limitation in litter, fermentation and humus layers of forest soil in the field, but the extent of regrowth after rehydration varied between layers. Nitrosospira 16S rRNA genes were ampl... Read More about Analysis of ammonia-oxidizing bacteria populations in acid forest soil during conditions of moisture limitation.

Determination of NTA and EDTA and Speciation of Their Metal Complexes in Aqueous Solution by Capillary Electrophoresis (2000)
Journal Article
Owens, G., Ferguson, V. K., McLaughlin, M. J., Singleton, I., Reid, R. J., & Smith, F. A. (2000). Determination of NTA and EDTA and Speciation of Their Metal Complexes in Aqueous Solution by Capillary Electrophoresis. Environmental science & technology, 34(5), 885-891. https://doi.org/10.1021/es990309m

The interest in the use of chelates for enhancing metal uptake by plants during phytoremediation and their widespread use in plant nutrient research requires that an easy, reproducible method be developed for chelate detection in a variety of systems... Read More about Determination of NTA and EDTA and Speciation of Their Metal Complexes in Aqueous Solution by Capillary Electrophoresis.

Persistence and effects of fenamiphos on native algal populations and enzymatic activities in soil (1999)
Journal Article
Megharaj, M., Singleton, I., Kookana, R., & Naidu, R. (1999). Persistence and effects of fenamiphos on native algal populations and enzymatic activities in soil. Soil Biology and Biochemistry, 31(11), 1549-1553. https://doi.org/10.1016/s0038-0717%2899%2900078-4

Fenamiphos is a commonly and widely used nematicide and insecticide in agriculture but information on its effects on microorganisms in soil is scarce. The microbial role in the persistence of fenamiphos in soil was determined by comparing the relativ... Read More about Persistence and effects of fenamiphos on native algal populations and enzymatic activities in soil.

Diversification of Pseudomonas corrugata 2140 produces new phenotypes altered in GC-FAME, BIOLOG, and in vitro inhibition profiles and taxonomic identification (1999)
Journal Article
Barnett, S. J., Alami, Y., Singleton, I., & Ryder, M. H. (1999). Diversification of Pseudomonas corrugata 2140 produces new phenotypes altered in GC-FAME, BIOLOG, and in vitro inhibition profiles and taxonomic identification. Canadian journal of microbiology, 45(4), 287-298. https://doi.org/10.1139/w99-006

Bacteria are known to rapidly produce new phenotypes, but it is unclear how phenotype "plasticity" relates to studies on the population ecology of bacteria in complex environments. We characterised a collection of 14 spontaneous phenotype variants, d... Read More about Diversification of Pseudomonas corrugata 2140 produces new phenotypes altered in GC-FAME, BIOLOG, and in vitro inhibition profiles and taxonomic identification.

Activated sludge foaming: The true extent of actinomycete diversity (1998)
Journal Article
Goodfellow, M., Stainsby, F., Davenport, R., Chun, J., & Curtis, T. (1998). Activated sludge foaming: The true extent of actinomycete diversity. Water Science and Technology, 37(4-5), 511-519. https://doi.org/10.1016/s0273-1223%2898%2900153-x

Isolates from activated sludge foam were provisionally assigned to the genera Gordona and Tsukamurella on the basis of colony morphology and pigmentation. Representatives of the first group were compared with marker strains of validly described speci... Read More about Activated sludge foaming: The true extent of actinomycete diversity.

Metal cation uptake by yeast: a review (1995)
Journal Article
Blackwell, K. J., Singleton, I., & Tobin, J. M. (1995). Metal cation uptake by yeast: a review. Applied microbiology and biotechnology, 43(4), 579-584. https://doi.org/10.1007/s002530050454

This review addresses metal uptake specifically by yeast. Metal uptake may be passive, active or both, depending on the viability of the biomass, and is influenced by a number of environmental and experimental factors. Uptake is typically accompanied... Read More about Metal cation uptake by yeast: a review.

Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major (1995)
Journal Article
Proudfoot, L., Schneider, P., Ferguson, M. A. J., & McConville, M. J. (1995). Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major. The biochemical journal, 308(1), 45-55. https://doi.org/10.1042/bj3080045

The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor. This parasite also synthesizes a complex family of abundant low-molecular-... Read More about Biosynthesis of the glycolipid anchor of lipophosphoglycan and the structurally related glycoinositolphospholipids from Leishmania major.

Considerations on the use of commercially available yeast biomass for the treatment of metal-containing effluents (1995)
Journal Article
Simmons, P., Tobin, J. M., & Singleton, I. (1995). Considerations on the use of commercially available yeast biomass for the treatment of metal-containing effluents. Journal of industrial microbiology, 14(3-4), 240-246. doi:10.1007/bf01569934

Three strains ofSaccharomyces cerevisiae and one strain of aCandida sp. obtained from different industrial sources were screened for uptake of silver and copper. Considerable differences in metal uptake capacities were found between the different str... Read More about Considerations on the use of commercially available yeast biomass for the treatment of metal-containing effluents.

Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis (1992)
Journal Article
Johnson, K. J., Sander, T., Hicks, A. A., van Marle, A., Janz, D., Mullan, M. J., …Darlison, M. G. (1992). Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis. Genomics, 14(3), 745-748. https://doi.org/10.1016/s0888-7543%2805%2980178-8

The GABAA receptor is the major inhibitory neurotransmitter receptor in the mammalian brain. To date, 14 genes that encode subunits of this receptor have been identified; these appear to be scattered throughout the human genome and are under investig... Read More about Confirmation of the localization of the human GABAA receptor α1-subunit gene (GABRA1) to distal 5q by linkage analysis.

Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain (1991)
Journal Article
Glencorse, T. A., Bateson, A. N., Hunt, S. P., & Darlison, M. G. (1991). Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain. Neuroscience Letters, 133(1), 45-48. https://doi.org/10.1016/0304-3940%2891%2990053-v

We have used sequence-specific oligonucleotide probes and in situ hybridisation histochemistry to examine the distributions of the GABAA receptor α1- and γ2-subunit mRNAs in serial sections of 1-day-old chick brain. Both transcripts are present toget... Read More about Distribution of the GABAA receptor α1- and γ2-subunit mRNAs in chick brain.